1.Causes of Death and Risk Factors for Mortality among HIV-Infected Patients Receiving Antiretroviral Therapy in Korea.
Sun Hee LEE ; Kye Hyung KIM ; Seung Geun LEE ; Heerim CHO ; Dong Hwan CHEN ; Joo Seop CHUNG ; Ihm Soo KWAK ; Goon Jae CHO
Journal of Korean Medical Science 2013;28(7):990-997
A retrospective study was conducted to determine the mortality, causes and risk factors for death among HIV-infected patients receiving antiretroviral therapy (ART) in Korea. The outcomes were determined by time periods, during the first year of ART and during 1-5 yr after ART initiation, respectively. Patients lost to follow-up were traced to ascertain survival status. Among 327 patients initiating ART during 1998-2006, 68 patients (20.8%) died during 5-yr follow-up periods. Mortality rate per 100 person-years was 8.69 (95% confidence interval, 5.68-12.73) during the first year of ART, which was higher than 4.13 (95% confidence interval, 2.98-5.59) during 1-5 yr after ART. Tuberculosis was the most common cause of death in both periods (30.8% within the first year of ART and 16.7% during 1-5 yr after ART). During the first year of ART, clinical category B and C at ART initiation, and underlying malignancy were significant risk factors for mortality. Between 1 and 5 yr after ART initiation, CD4 cell count < or = 50 cells/microL at ART initiation, hepatitis B virus co-infection, and visit constancy < or = 50% were significant risk factors for death. This suggests that different strategies to reduce mortality according to the time period after ART initiation are needed.
Anti-Retroviral Agents/*adverse effects/*therapeutic use
;
Antiretroviral Therapy, Highly Active/adverse effects
;
CD4 Lymphocyte Count
;
Cause of Death
;
Coinfection
;
Female
;
HIV Infections/*drug therapy/*mortality/virology
;
Humans
;
Male
;
Middle Aged
;
Republic of Korea
;
Retrospective Studies
;
Risk Factors
;
Treatment Outcome