1.Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea.
Joon Sung JOH ; H Christian HONG ; In A JEONG ; Bum Sik CHIN ; Hye Jin YANG ; Hongjo CHOI ; Ji Hwan BANG
Journal of Korean Medical Science 2012;27(10):1143-1146
Much controversy surrounds the issue of whether HIV infection is a risk factor for developing multidrug-resistant tuberculosis (MDR-TB). In this study, we evaluated the prevalence of and risk factors for MDR-TB in HIV-infected patients at the National Medical Center of Korea. We reviewed the medical records of HIV/TB co-infected patients from January 2005 to May 2011; the drug susceptibility profiles were available for 55 patients. Of these, 32.7% had MDR-TB, which was approximately 3.6 times higher than the prevalence among the general population. Additionally, there were more additional AIDS-defining clinical illnesses in the MDR-TB group than in the non-MDR-TB group (27.8% vs 5.4%, P = 0.032). These results suggest that HIV infection and HIV-related immunosuppresion may contribute to the development of MDR-TB.
Adult
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Aged
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Coinfection
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Female
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HIV Infections/*complications/*epidemiology/microbiology
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Humans
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Immunosuppression
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Male
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Middle Aged
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Mycobacterium tuberculosis/isolation & purification
;
Prevalence
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Republic of Korea/epidemiology
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Retrospective Studies
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Risk Factors
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Tuberculosis, Multidrug-Resistant/*complications/*epidemiology/microbiology
2.A Case of Epstein-Barr Virus Infection with Gall Bladder and Common Bile Duct Stones in an Otherwise Healthy Child.
Jong Hyun PARK ; Jin Chul NOH ; Hyang Mi PARK ; Yu Soek JUNG ; Sei Hyeog PARK ; H Christian HONG ; Hye Jung SHIN
Pediatric Gastroenterology, Hepatology & Nutrition 2012;15(1):57-61
Cholelithiasis and choledocholithiasis are uncommon pediatric diseases, although clinicians have seen them with increasing frequency in children in recent years. Moreover, no case of Epstein-Barr virus (EBV) infection with cholelithiasis and choledocholithiasis has been previously reported in the English literature. We report a pediatric patient with EBV infection, a gall bladder stone, and a common bile duct stone, may have had GB and CBD stones prior to her EBV infection, whom we successfully treated with antibiotics and laparoscopic cholecystectomy for cholecystitis.
Anti-Bacterial Agents
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Child
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Cholecystectomy, Laparoscopic
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Cholecystitis
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Choledocholithiasis
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Cholelithiasis
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Common Bile Duct
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Epstein-Barr Virus Infections
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Herpesvirus 4, Human
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Humans
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Urinary Bladder
;
Urinary Bladder Calculi
3.A Case of Asymptomatic, Localized, and Idiopathic Diffuse Alveolar Damage.
Young Do JEON ; H Christian HONG ; Joon Sung JOH ; Ja Young JUNG ; Ji Won MIN ; Seon Young PARK ; Ga Ram LEE
Tuberculosis and Respiratory Diseases 2012;72(4):386-389
Diffuse alveolar damage (DAD) is a histological change in lung tissue, and is generally caused by an acute lung injury, which is characterized by bilateral and widespread damages. Localized DAD occurs very rarely. The causes for DAD are numerous, but the chief cause is acute interstitial pneumonia or acute exacerbation of idiopathic interstitial pneumonia, in cases of idiopathic manifestation. The 82-year-old patient, in this case study, showed a DAD lesion in only 1 lobe. The patient was otherwise healthy, with no previous symptoms of DAD. He was admitted to our medical center owing to localized infiltration, observed on his chest radiograph. Laboratory studies showed no signs of infections. DAD was confirmed by a surgical lung biopsy. The patient received corticosteroid treatment and had gradually improved. We report the case of a patient with localized, idiopathic DAD that cannot be classified as acute interstitial pneumonia or acute exacerbation of idiopathic interstitial pneumonia.
Acute Lung Injury
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Aged, 80 and over
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Biopsy
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Humans
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Idiopathic Interstitial Pneumonias
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Idiopathic Pulmonary Fibrosis
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Lung
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Lung Diseases, Interstitial
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Lung Injury
;
Thorax
4.Lymphobronchial Fistula of Tuberculous Lymphadenitis in Acquired Immunodeficiency Syndrome.
Ju Hwa YOON ; Ja Young JUNG ; Ji Won MIN ; Seon Young PARK ; Young Do JEON ; H Christian HONG ; Ji Hwan BANG ; Joon Sung JOH
Infection and Chemotherapy 2012;44(1):35-39
Bronchial invasion of tuberculous lymphadenitis in children has been reported in areas of high tuberculosis (TB) prevalence as a complication due to primary pulmonary tuberculosis. However, it is rare in immunocompetent adults. When it appears, it often presents as a consequence of the reactivation of TB in the lung parenchyma. Primary TB occurs more frequently in patients with human immunodeficiency virus (HIV), with a history of organ transplants, or undergoing immunosuppressive treatments such as steroids. Furthermore, bronchial invasion of the bronchus by tuberculous lymphadenitis is considered to be very rare even among immunocompromised adults with primary TB, and has never before been reported in Korea. The authors report a case of bronchial invasion of the bronchus by tuberculous lymphadenitis, confirmed by bronchoscopy, in an Acquired Immunodeficiency Syndrome (AIDS) patient.
Acquired Immunodeficiency Syndrome
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Adult
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Bronchi
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Bronchoscopy
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Child
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Fistula
;
HIV
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Humans
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Korea
;
Lung
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Lymph Nodes
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Prevalence
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Steroids
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Transplants
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Tuberculosis
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Tuberculosis, Lymph Node
;
Tuberculosis, Pulmonary
5.An Alternative Approach to Tuberculosis Management with Intravenous Streptomycin.
Sang Young KIM ; H Christian HONG ; Jong Hun KIM ; Ji Won RYU ; Han Seop CHOI ; Yeon Tae CHUNG ; Joon Sung JOH
Infection and Chemotherapy 2010;42(1):39-42
Streptomycin is currently utilized to treat advanced tuberculosis in Korea. However, the usefulness of intravascular streptomycin is not fully understood. In this study, streptomycin was administered intravenously in 30 patients. Intravenous administration of streptomycin may be a useful route of administration without undesirable toxicities.
Administration, Intravenous
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Humans
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Korea
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Mycobacterium tuberculosis
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Streptomycin
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Tuberculosis