No abstract available.
Female ; Gonadotropin-Releasing Hormone* ; Humans ; Leiomyoma* ; Single Person*

No abstract available.
Pregnancy* ; Uterine Rupture*

Purpose: Reduced port laparoscopic distal gastrectomy (RPLDG) using 3 ports is less invasive than conventional laparoscopic distal gastrectomy (CLDG) using 5 ports. Although RPLDG performed by expert surgeons is safe and feasible, novice surgeons have difficulty performing this procedure. This study evaluated the surgical outcomes and feasibility of RPLDG performed by a novice surgeon. Materials and Methods: The records of 136 patients who underwent laparoscopic distal gastrectomy for gastric cancer performed by a single novice surgeon between May 2016 and December 2018 were retrospectively reviewed. Among these 136 patients, 52 underwent RPLDG and 84 underwent CLDG. The clinicopathological characteristics, operative outcomes, and short-term postoperative outcomes of the 2 groups were compared. Results: The percentage of women was significantly higher in the RPLDG group than in the CLDG group (48.1% vs. 31%; P=0.045), but other baseline characteristics did not differ significantly between the groups. Billroth II anastomosis was performed significantly more frequent (90.4% vs. 73.8%, P=0.015) and operation time was significantly shorter (207.1±43.3 min vs. 225.5±44.6 min, P=0.020) in the RPLDG group than in the CLDG group. The time to first flatus, postoperative pain score, length of postoperative hospital stay, and incidence and severity of complications did not differ significantly between the groups. Analysis of the learning curve based on the operation time showed that performing RPLDG on 20–30 patients was required to achieve technical proficiency. Conclusions RPLDG is a safe and feasible surgical procedure for the treatment of gastric cancer, even when performed by a novice surgeon.

No abstract available.

No abstract available.
Acute Lung Injury* ; Animals ; Hydroxyl Radical* ; Rats*

No abstract available.
Lung Neoplasms* ; Lung* ; Mass Screening* ; Seoul*

No abstract available.
Acute Lung Injury* ; Capillaries* ; Oxygen*

The relevance of transglutaminases with neural function and several disorders has been emphasized recently. Especially, many polypeptides associated with neurodegenerative diseases are suggested to be putative transglutaminase substrates such as beta amyloid protein of Alzheimer's disease, microtubule-associated proteins and neurofilaments, etc. In addition, the CAG repeated gene products with probable polyglutamine tract, putative transglutaminase substrates, were identified in several neurodegenerative disorders. However, the identity of the brain transglutaminase has not been confirmed, because of enzymic stability and low activity. In the present experiment, we have isolated brain-specific transglutaminases, designated as TGase NI and TGase NII, which are different from other types of transglutaminases in respects of molecular weights (mw. 45 kDa, 29 kDa respectively), substrate affinity, elution profile on ion-exchange chromatography, sensitivity to proteases and ethanol, and immunological properties. The enzymes were localized specifically in the brain tissues but not in the liver tissue. And neural cells such as pheochromocytoma cell, glioma cell, primary neuronal and glial cells were shown to be enriched with TGase NI and TGase NII. The possible biological roles of the enzymes were discussed not only on the aspect of crosslinking activity but also of signal transducing capacity of the enzyme in the brain.
Animal ; Astrocytes/enzymology ; Blotting, Western ; Brain/enzymology* ; Calcium/metabolism ; Chromatography, Ion Exchange ; Endopeptidases/pharmacology ; Enzyme Stability ; Ethanol/pharmacology ; Glioma ; Immunoblotting ; Immunohistochemistry ; Male ; Molecular Weight ; Neurons/enzymology ; PC12 Cells ; Protein-Glutamine gamma-Glutamyltransferase/isolation & purification* ; Protein-Glutamine gamma-Glutamyltransferase/immunology ; Protein-Glutamine gamma-Glutamyltransferase/chemistry* ; Rats ; Rats, Sprague-Dawley ; Trypsin/pharmacology ; Tumor Cells, Cultured

No abstract available.
Anemia* ; Bone Marrow Transplantation* ; Bone Marrow*

No abstract available.
Acute Lung Injury* ; Prostaglandin-Endoperoxide Synthases* ; Sus scrofa*