1.In Vivo reaction of the Highly Porous Glass Ceramics in the Rabbit Tibia: Radiological and Histological Analysis
Young Min KIM ; Hee Joong KIM ; Gyu Hwan KIM ; Jae Il LEE ; Soo Taek LIM
The Journal of the Korean Orthopaedic Association 1996;31(4):844-851
To evaluate the possibility of the newly developed highly porous glass ceramics as a space-filler in the cavitary bone defect, we made the opening sized 1 × 0.5 cm on the medial aspect of the right proximal tibia of nine rabbits. We impacted the highly porous glass ceramics firmly to the medullary cavity of rabbit tibia through the opening. Each three were sacrificed at 4th, 8th, and 12th week and analyze in vivo reaction of the glass ceramics in rabbit tibia with radiological and histological methods. On radiological examination, radiolucent line was seen around impacted glass ceramics at 4th week, but this radiolucent line was obliterated gradually to 12th week. On histological examination, new bone formation with osteoblast was appeared at 4th week without foreign body reactions. At 8th week, newly formed bone infiltrated into the porous space between glass ceramics particles was noticed, and the surface of glass ceramics was tightly bound by newly formed bone with osteoblastic rim and mature bone, At 12th week, the amount of newly formed mature bone increased, though there was on evidence of resorption of glass ceramics particle. So, we suggest that the highly porous glass ceramics is one of the possible artificial bone graft substitutes, especially as a space-filler.
Ceramics
;
Foreign Bodies
;
Glass
;
Osteoblasts
;
Osteogenesis
;
Rabbits
;
Tibia
;
Transplants
2.Four cases of edward syndrome with abnomal prenatal ultrasonographic findings.
Nam Gyu CHO ; Kyung Ik KWON ; Dong Ho NAM ; Chun Gun LIM ; Ho Chung RYU ; Jong In KIM ; Taek Hoon KIM
Korean Journal of Perinatology 1993;4(4):599-609
No abstract available.
3.2 cases of inguinal hernia in patients treated by continuous ambulatory peritoneal dialysis: use of radionuclide imaging peritoneography.
Soung Soo KIM ; Gyu Taek LIM ; In Seok PARK ; Yoon Sik CHANG ; Byung Kee BANG ; Hyung Sun SOHN
Korean Journal of Nephrology 1991;10(3):439-442
No abstract available.
Hernia, Inguinal*
;
Humans
;
Peritoneal Dialysis, Continuous Ambulatory*
;
Radionuclide Imaging*
4.A case of idiopathic rhabdomyolysis in a patient with chronic renal insufficiency.
Soung Soo KIM ; Gyu Taek LIM ; Chul Woo YANG ; Suk Young KIM ; In Seok PARK ; Yoon Sik CHANG ; Byung Kee BANG
Korean Journal of Nephrology 1992;11(2):173-179
No abstract available.
Humans
;
Renal Insufficiency, Chronic*
;
Rhabdomyolysis*
5.A Case of Adult onset Bartter Syndrome with Nephrocalcinosis.
Min Gyu PARK ; Tae Won LIM ; Hee Taek OH ; Seung Un SONG ; Dong HEO ; Hark RIM
Kosin Medical Journal 2014;29(1):75-79
Bartter syndrome is a renal tubular defect in electrolyte transport characterized by hypokalemia, metabolic alkalosis, hyperreninemia, hyperaldosteronism, normal blood pressure, and other clinical symptoms. As a clinical and genetical heterogeneous disorder, this syndrome can be classified into two clinical variants, antenatal Bartter syndrome and classic Bartter syndrome according to the onset age. Nephrocalcinosis is common in antenatal Bartter syndrome, but is rare in classic Bartter syndrome. It can also be classified into five genetic subtypes by the underlying mutant gene, all of which are expressed in the tubular epithelial cells of the thick ascending limb of the loop of Henle. Patients with Bartter syndrome type 1, 2 and 4 present at a younger age than classic Bartter syndrome type 3. We have experienced a case of Bartter syndrome with nephrocalcinosis in a 42-year-old woman diagnosed by biochemical and radiologic studies. We had successful response with potassium chloride and spironolactone.
Adult*
;
Age of Onset
;
Alkalosis
;
Bartter Syndrome*
;
Blood Pressure
;
Epithelial Cells
;
Extremities
;
Female
;
Humans
;
Hyperaldosteronism
;
Hypokalemia
;
Loop of Henle
;
Nephrocalcinosis*
;
Potassium Chloride
;
Spironolactone
6.Revisiting anemia afer ABO-mismatched allogeneic bone marrow transplantation.
Gyu Taek LIM ; Dong Wook KIM ; Jong Youl JIN ; Jong Wook LEE ; Chi Wha HAN ; Woo Sung MIN ; Chong Won PARK ; Choon Choo KIM ; Dog Jip KIM
Korean Journal of Hematology 1991;26(1):13-21
No abstract available.
Anemia*
;
Bone Marrow Transplantation*
;
Bone Marrow*
7.Change of Post-anesthetic Recovery Time after Colorectal Surgery with N-acetyl-cysteine Infusion.
In Ho HA ; Kyung Hwa KWAK ; Chang Gyu HAN ; In Taek LEE ; Gyu Seog CHOI ; InKyeom KIM ; Woon Yi BAEK ; Dong Gun LIM
Korean Journal of Anesthesiology 2006;51(4):436-442
BACKGROUND: The gut is an important area for inflammatory responses. Gut manipulation during open laparotomy compared with laparoscopic surgery, increases the inflammatory responses. Laparoscopic assisted colectomy (LC) with less bowel manipulation might minimize the inflammatory responses and oxidative stress, and offer a faster postanesthetic recovery than an open colectomy (OC). This study evaluated the effect of N-acetyl-cysteine (NAC), an antioxidant, on the recovery after colectomy. METHODS: 116 colorectal tumor patients were reviewed retrospectively. The patients were divided into 3 groups; LC by surgeon A (A - L), OC by surgeon A (A - O) and OC by surgeon B (B - O). The postanesthetic recovery scores (PARS) were compared. In the prospective randomized controlled trial, the colorectal tumor patients were assigned to one of four groups; laparoscopic assisted colectomy (L - N) with NAC infusion (L + N), open colectomy (O - N) with NAC infusion (O + N). In the NAC groups, NAC (5 mg/kg/h) was infused after intubation to extubation. The PARS were compared. RESULTS: In the retrospective study, the time to reach 10 points, which satisfies the discharge criteria in the PACU, was significantly lower in the A-L group than in the other groups. In the prospective study, the time to 10 points was shorter in the O + N group than in the O-N group. NAC offered no added benefits to the L + N and L-N groups. CONCLUSIONS: NAC offered faster recovery in the OC group but not in the LC group.
Colectomy
;
Colorectal Neoplasms
;
Colorectal Surgery*
;
Humans
;
Intubation
;
Laparoscopy
;
Laparotomy
;
Oxidative Stress
;
Prospective Studies
;
Retrospective Studies
8.Thrombotic thrombocytopenic purpura-like syndrome associated with systemic lupus erythematosus: combined treatment with plasmapheresis and fresh frozen plasma infusion.
Gyu Taek LIM ; Sung Soo KIM ; Soo Hun PARK ; Won Oh CHOO ; Dong Heon KANG ; In Seok PARK ; Yoo Sik CHANG ; Young Suk YOON ; Byung Kee BANG
Journal of Korean Medical Science 1992;7(1):66-70
We report on a patient with systemic lupus erythematosus, who, during the course of the illness, developed thrombotic thrombocytopenic purpura. In this case, the coexistence of these two conditions was confirmed by laboratory and pathologic findings. The infusion of fresh frozen plasma with plasmapheresis reversed the course of thrombotic thrombocytopenic purpura.
Adult
;
*Blood Transfusion
;
Combined Modality Therapy
;
Humans
;
Lupus Erythematosus, Systemic/*complications
;
Male
;
*Plasma
;
*Plasmapheresis
;
Purpura, Thrombotic Thrombocytopenic/etiology/*therapy
;
Syndrome
9.Antitunor effect of carcinoma cells transduced with herpes simplex virus - thymidine kinase by gancyclovir and radiation.
Jae Woo LEE ; Seong Taek OH ; Chan Hyuk AHN ; Kun Woo LIM ; Hyun Il CHO ; Gum Ryong KIM ; Tai Gyu KIM
Immune Network 2001;1(1):45-52
BACKGROUND: Many types of cancer become resistant to current chemotherapeutic and radiotherapeutic intervention. To overcome this situation application of gene therapy by the introduction of suicide genes followed by their prodrugs may be promising. A viral enzyme, Herpes simplex thymidine kinase (HSV-tk), which converts ganciclovir from an inactive prodrug to a cytotoxic agent by phosphorylation, are being actively investigated for use in gene therapy for cancer. The purpose of this study was to determine whether combining prodrug-activating gene therapy and irradiation might result in enhanced antitumor effects. METHODS: The HSV-tk gene was cloned into the retroviral vector, pLXSN and established the clones producing retroviruses carrying the HSV-tk gene. The carcinoma cell line, HCT116 and Huh-7 were transduced with high-titer recombinant retroviruses. These cell lines were treated with ganciclovir before or after irradiation for the defining combinational effect of suicide gene therapy and radiotherapy. RESULTS: The titers of cloned PA3 17 amphotropic retroviruses ranged from 4 to 6 X 10(6) CFU/ml . After selectional periods, the expression of HSV-tk was confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR). The growth of cells expressing HSV-tk was inhibited as increase of GCV dose after 48 hr and the growth inhibitory effect of GCV was much higher after 72 hr. When the cells transduced with HSV-tk gene were exposed to radiation, the growth inhibitory effect of GCV was significantly increased, as compared with non-transduced parental cells. CONCLUSIONS: The result s suggest that the addition of HSV-tk gene therapy to standard radiation therapy may improve the effectiveness of treatment for solid tumors.
Cell Line
;
Clone Cells
;
Ganciclovir*
;
Genetic Therapy
;
Herpes Simplex*
;
Humans
;
Parents
;
Phosphorylation
;
Polymerase Chain Reaction
;
Prodrugs
;
Radiotherapy
;
Retroviridae
;
Simplexvirus*
;
Suicide
;
Thymidine Kinase*
;
Thymidine*
;
Zidovudine
10.Study for the Lack of Mental Changes to Severe Hyperglycemia in Diabetic Patients with Renal Failure.
Hyung Jung WI ; Chang Bum LEE ; Sung Kwang PARK ; Sung Kyew KANG ; Chun Gyu LIM ; Kyung Taek YUN ; Eun Joo PARK ; Sang Woong HAN ; You Hern AHN ; Ho Jung KIM
Korean Journal of Nephrology 2000;19(6):1086-1090
In diabetic patients who were being treated with hemodialysis, coma and other neurological deficits did not occur in spite of extremely elevated serum glucose levels. In this report, we compared diabetic patients with renal failure in severe hyperglycemia with nonketotic hyperosmolar coma patients with normal renal function to know what affect mental changes. Mental changes were not present in diabetic patients with renal failure. These patients with renal failure showed more severe hyperglycemia, but corrected serum sodium concentration and calculated effective serum osmolality were low. So it is suggested that corrected serum sodium concentration and effective serum osmolality are more important factor affecting mental changes than high blood glucose levels in diabetic patients with renal failure, due to absence of osmotic diuresis.
Blood Glucose
;
Coma
;
Diuresis
;
Humans
;
Hyperglycemia*
;
Osmolar Concentration
;
Renal Dialysis
;
Renal Insufficiency*
;
Sodium