1.Journal of Korean Neurosurgical Society for 30 Years.
Journal of Korean Neurosurgical Society 2002;32(4):371-375
The end of this month is the 30th birthday of Journal of Korean Neurosurgical Society. Since the first issue of Journal of Korean Neurosurgical Society published in October, 1972, it has been developed in its quality as well as the quantity. More than 4000 articles have been published and tremendous contribution for the development of Korean Neurosurgical Society was made by the journal. The authors review the history of Journal of Korean Neurosurgical Society including the problems in this situation and suggest the way to make the journal as an internationally famous one.
Korea
;
Neurosurgery
2.Effects of administration of IH901, a ginsenoside intestinal metabolite, on muscular and pulmonary antioxidant functions after eccentric exercise.
Nam Jin LEE ; Jung Won LEE ; Jong Hwan SUNG ; Yeoung Gyu KO ; Seongsoo HWANG ; Jong Koo KANG
Journal of Veterinary Science 2013;14(3):249-256
This study was conducted to investigate whether administration of IH901, a ginseng intestinal metabolite, ameliorates exercise-induced oxidative stress while preserving antioxidant defense capability in rat skeletal muscles and lung. Eight adult male Sprague-Dawley rats per group were randomly assigned to the resting control, exercise control, resting with IH901 (25, 50, and 100 mg/kg) consumption (R/IH901), or exercise with IH901 (25, 50, and 100 mg/kg) consumption (E/IH901) group. The trained groups ran 35 min 2 days/week for 8 weeks. To analyze the IH901-training interaction, serum biochemical analysis, lipid peroxidation, citrate synthase, protein oxidation, antioxidant and superoxide dismutase in skeletal muscles and lung tissue were measured. Compared to the exercise control group, animals that consumed IH901 had significantly increased exercise endurance times (p < 0.05) and decreased plasma creatine kinase and lactate dehydrogenase levels (p < 0.05), while those in the E/IH901 groups had increased citrate synthase and anti-oxidant enzymes and decreased lipid peroxidation and protein oxidation (p < 0.05). In conclusion, IH901 consumption in aging rats after eccentric exercise has beneficial effects on anti-inflammatory and anti-oxidant activities through down-regulation of pro-inflammatory mediators, lipid peroxidation, and protein oxidation and up-regulation of anti-oxidant enzymes.
Aging
;
Animals
;
Antioxidants/administration & dosage/*pharmacology
;
Dose-Response Relationship, Drug
;
Lung/*drug effects/metabolism
;
Male
;
Muscle, Skeletal/*drug effects/metabolism
;
Oxidative Stress/*drug effects
;
Panax/chemistry
;
Physical Conditioning, Animal
;
Rats
;
Rats, Sprague-Dawley
;
Sapogenins/administration & dosage/blood/*metabolism/*pharmacology
;
Specific Pathogen-Free Organisms
3.Primary Pure Squamous Cell Carcinoma Originating from the Stomach.
Ji Ha KIM ; Jong Ho HWANG ; Sun Hui HWANG ; Sang Ho LEE ; Jae Nam LEE ; Jae Hoon CHEUNG ; Dong Hoon HAN ; Jae Gyu SHIN
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2014;14(2):126-130
Primary gastric squamous cell carcinoma represents a rare entity. Up to date, only seven cases have been reported in Korea. This paper reports a case of a 51-year-old male patient whose stomach cancer was diagnosed during general routine check-up. Upper gastrointestinal endoscopy showed a large ulcero-fungating mass on the body of the stomach. Histological examination of biopsy confirmed squamous cell carcinoma. An extended total gastrectomy including splenectomy and segmental resection of the large bowel was conducted. Postoperative adjuvant chemotherapy with capecitabine and oxaliplatin was followed. The patient has been following up the out patient's clinic after discharge.
Biopsy
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Carcinoma, Squamous Cell*
;
Chemotherapy, Adjuvant
;
Endoscopy, Gastrointestinal
;
Gastrectomy
;
Humans
;
Korea
;
Male
;
Middle Aged
;
Splenectomy
;
Stomach Neoplasms
;
Stomach*
;
Capecitabine
4.Primary Pure Squamous Cell Carcinoma Originating from the Stomach.
Ji Ha KIM ; Jong Ho HWANG ; Sun Hui HWANG ; Sang Ho LEE ; Jae Nam LEE ; Jae Hoon CHEUNG ; Dong Hoon HAN ; Jae Gyu SHIN
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2014;14(2):126-130
Primary gastric squamous cell carcinoma represents a rare entity. Up to date, only seven cases have been reported in Korea. This paper reports a case of a 51-year-old male patient whose stomach cancer was diagnosed during general routine check-up. Upper gastrointestinal endoscopy showed a large ulcero-fungating mass on the body of the stomach. Histological examination of biopsy confirmed squamous cell carcinoma. An extended total gastrectomy including splenectomy and segmental resection of the large bowel was conducted. Postoperative adjuvant chemotherapy with capecitabine and oxaliplatin was followed. The patient has been following up the out patient's clinic after discharge.
Biopsy
;
Carcinoma, Squamous Cell*
;
Chemotherapy, Adjuvant
;
Endoscopy, Gastrointestinal
;
Gastrectomy
;
Humans
;
Korea
;
Male
;
Middle Aged
;
Splenectomy
;
Stomach Neoplasms
;
Stomach*
;
Capecitabine
5.Clinical Significance of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Gene Polymorphism in Korean Patients with Gastric Cancer.
Jun LEE ; Cheol Kweon JEONG ; Sung Pyo HONG ; So Young CHONG ; Doyeun OH ; Seong Gyu HWANG ; Dae Ho AHN ; Sehyun KIM ; Jin Hee HAN ; Nam Keun KIM
The Korean Journal of Gastroenterology 2005;46(1):32-38
BACKGROUND/AIMS: Thymidylate synthase (TS) is a target enzyme of 5-fluorouracil (5-FU) and has a polymorphic 28 bp tandem repeated sequence. TS enhancer region (TSER) polymorphism has been associated with the efficacy of 5-FU-based chemotherapy in colon cancer. Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to methyl donor for DNA methylation. The aim of this study was to determine the clinical value of TSER and MTHFR polymorphism in gastric cancer. METHODS: From October, 1995 to February, 2002, 40 gastric cancer patients underwent operation and 25 patients among those patients have received postoperative 5-FU-based chemotherapy (5-FU (+) group). Peripherial blood were sampled for TSER and MTHFR genotype analysis by PCR amplification of genomic DNA. The survival of patients according to TSER and MTHFR polymorphism were compared. RESULTS: We observed a longer survival in stage II than stage III of the patients (p=0.0037). However, the TSER and MTHFR C677T polymorphisms were not associated with better survival of gastric cancer patients as well as combined TSER and MTHFR genotypes with 5-FU chemotherapy. CONCLUSIONS: The TSER and MTHFR genotypes are not effective markers for tumor sensitivity to 5-FU-based chemotherapy in Korean gastric cancer patients after curative resection. These results may suggest further large-scale study about TSER and MTHFR polymorphism for the prediction of efficacy of 5-FU-based chemotherapy in gastric cancer in Korea.
Aged
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Antimetabolites, Antineoplastic/*therapeutic use
;
Drug Screening Assays, Antitumor
;
Female
;
Fluorouracil/*therapeutic use
;
Humans
;
Male
;
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
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Middle Aged
;
*Polymorphism, Genetic
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Stomach Neoplasms/*drug therapy/genetics/mortality
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Survival Rate
;
Thymidylate Synthase/*genetics
6.Three Cases of Esophageal Granular Cell Tumor.
Jeon Hong KANG ; Hyung Keun BONG ; Young Hong LEE ; Jin Oh KIM ; Joo Young CHO ; Moon Sung LEE ; Seong Gyu HWANG ; Chan Sup SHIM ; Dong Won KIM ; Dong Wha LEE
Korean Journal of Gastrointestinal Endoscopy 1998;18(4):543-551
Granular cell tumors (GCT), previously termed granular cell myoblastorna, was first described as a myoblastic myoma of the tongue in 1926 by Abrikossoff and has been reported in many different locations throughout the body. In 1931, Abrikossaff described the first granular cell tumor of the esophagus. The gastrointestinal tract is one of the more uncommon locations for granular cell tumors. Until recently, granular cell tumors had been considered rare but, the incidence of granular cell tumors has been slowly raising since endoscopy has been used more commonly as a diagnostic tool. In this study, we report three cases of esophageal granular cell tumors which were successfully diaganosed by an esophagoscopy and an endoscopic ultrasonography and confirmed using an endoscopic esophageal mucosal resection (EEMR).
Endoscopy
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Endosonography
;
Esophagoscopy
;
Esophagus
;
Gastrointestinal Tract
;
Granular Cell Tumor*
;
Incidence
;
Myoblasts
;
Myoma
;
Tongue
7.Techniques and Indications for a Central Bisegmentectomy of the Liver.
Shin HWANG ; Sung Gyu LEE ; Young Joo LEE ; Kwang Min PARK ; Dong Lak CHOI ; Ki Hoon KIM ; Choong Hyun NAM ; Pyung Chul MIN
Journal of the Korean Surgical Society 1999;57(5):708-714
BACKGROUND: Central bisegmentectomy (CBS) of the liver is a resection of the medial and anterior segments for preserving more liver parenchyma and reaching the goal of a curative resection simultaneously. PURPOSE: In this paper, we describe the indications and the techniques for this surgical procedure. PATIENTS AND METHODS: We reviewed the case histories of 14 patietns who had undergone a CBS, including 9 with a hepatocellular carcinoma, 4 with hilar bile-duct cancer, 1 with metastatic colon cancer, and 1 with gallbladder cancer. Eight patients had undergone a CBS with an operating time of only 353 minutes; 5 cases had undergone a CBS and a caudate lobectomy plus bile-duct resection, requiring an operating time of 762 minutes. A hepaticojejunostomy to right posterior hepatic duct was added to one CBS case because of intrahepatic ductal variation. The surgical technique for the CBS only procedure was as follows: demarcation of the dissection line with a selective block of the glissonian cord, division of the medial and the lateral segments along the falciform ligament to expose the left hepatic vein, and division of the anterior and the posterior segments along the right hepatic vein. In the combined bile-duct-resection cases, complete dissection of the hepatoduodenal ligament and biliary reconstruction were added. RESULTS: The extent of liver resection, as estimated by CT volumetry, was about 42%, and the mean value of the real weights of the specimens was 474 gm. The preoperative hepatic function showed a 9.3% indocyanine-green retention rate at 15 minutes, and 5 out of 9 hepatocellular carcinoma cases revealed concomitant liver cirrhosis. For CBS and additional procedures, the curative resection rate reached 93%, and the survival rate was favorable. There were no operative mortalities or hepatic failures. CONCLUSIONS: For selected cases of centrally located liver tumors or hilar bile-duct cancer with limited hepatic reserve, CBS may provide a safe, curative resection.
Carcinoma, Hepatocellular
;
Colonic Neoplasms
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Gallbladder Neoplasms
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Hepatic Duct, Common
;
Hepatic Veins
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Humans
;
Ligaments
;
Liver Cirrhosis
;
Liver*
;
Mortality
;
Survival Rate
;
Weights and Measures
8.Therapeutic potentials occurring during the early differentiation process of mesenchymal stem cells in a rats model with thioacetamide-induced liver fibrosis.
Sang Tae CHOI ; Shin HWANG ; Hea Nam HONG ; You Jin WON ; Chul Soo AHN ; Tae Yong HA ; Gi Won SONG ; Dong Hwan JUNG ; Gil Chun PARK ; Sung Gyu LEE
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2013;17(1):21-33
BACKGROUNDS/AIMS: Mesenchymal stem cells (MSCs) have the capacity to differentiate into hepatocytes, The purpose of this study is to investigate the MSCs' differentiation process and therapeutic potentials by comparing isolated MSCs with HGF-treated MSCs in rat's model with thiacetamide (TAA)-induced cirrhosis. METHODS: Male Sprague-Dawley (SD) rats, weighing 100-150 g were used in this study. To induce liver fibrosis, recipient rats were taken with 0.04% thioacetamide (TAA) in the drinking water (400 mg TAA/L) for 8 weeks. The rats underlying liver cirrhosis were divided into 3 groups according to the transplanted materials, compared to normal saline as control (I) and isolated MSCs (II) HGF-treated MSCs. RESULTS: Severe hepatic fibrosis and hepatocyte destruction were detected in the control group. Less hepatic cirrhosis and collagen formation, more hepatocyte regeneration and glycogen storage were detected in isolated MSCs compared to HGF-treated MSCs group, Distribution of red autofluorescence is mainly localized near the sinusoids in isolated MSCs, scattered away the sinusoids in HGF-treated MSCs group. MSCs transdifferentiated into CK-19 postive Oval cells and then to albulmin-producing hepatocytes, HGF treated MSCs differentiated into hepatocyte without the intermediate oval cells phase. HGF treated MSCs became the CK18-positive, MSCs became CD 90-positive. CONCLUSIONS: Significant hepatocyte differentiation occurred in not HGF-treated MSCs but isolated MSCs group unexpectedly. These results suggest that the beneficial effect of MSCs on in rat's model with TAA-induced cirrhosis may occur during early differentiation course of MSCs. Mature hepatocyte itself has a little effect on the accelerated differentiation and functional capacity of hepatic lineage cell-line.
Animals
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Collagen
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Drinking Water
;
Fibrosis
;
Glycogen
;
Hepatocytes
;
Humans
;
Liver
;
Liver Cirrhosis
;
Male
;
Mesenchymal Stromal Cells
;
Rats
;
Regeneration
;
Thioacetamide
;
Transplants
9.Results of Use of Hepatitis B Core Antibody-Positive Donors in Living Donor Liver Transplantation with Passive Immunoprophylaxis.
Dong Lak CHOI ; Sung Gyu LEE ; Young Joo LEE ; Kwang Min PARK ; Shin HWANG ; Ki Hun KIM ; Choong Hyeon NAM ; Chul Soo AHN ; Jae Han JEONG ; Pyung Chul MIN
Korean Journal of Hepato-Biliary-Pancreatic Surgery 1999;3(2):25-31
BACKGROUND: In Korea, the number of patients enrolled in liver transplantation registry exceeds the supply of cadaveric donor. This donor shortage leads to living donor liver transplantation(LDLT). Due to wide prevalence of hepatitis B in Korea, many healthy donors for LDLT shows hepatitis B surface antigen-negative[HBsAg(-)] and core antibody-positive [HBcAb(+)]. However, the risk of using graft livers from HBsAg(-) and HBcAb(+) donors has not been clearly defined. The aim of this study is to identify the safety of using HBcAb(+) donor and the effectiveness of passive immunoprophylaxis with hepatitis B immunoglobulin(HBIG) in non-hepatitis B virus induced cirrhotic recipients. METHODS: From December 1994 to July 1998, 59 patients underwent living donor liver transplantation at the Asan Medical Center. Among them, 35 cases were non-hepatitis B virus induced cirrhotic recipients. Of these 35 recipients, 14 patients received liver graft from HBsAg(-) and HBcAb(+) donors and prophylactic passive immunoprophylaxis with HBIG. RESULTS: Eleven cases remained HBsAg(-) with HBIG immunoprophylaxis. Three of 14 recipients who were HBsAg(-) converted to HBsAg(+) serologically after receiving HBcAb(+) donor liver. All of these 3 cases did not receive HBIG therapy. CONCLUSIONS: Passive immunoprophylaxis with HBIG may prevent non-hepatitis B induced cirrhotic recipients from converting to HBsAg(+) status by using HBcAb(+) donor. Our experience suggests that HBcAb(+) donors can be accepted as potential donors in living donor liver transplantation.
Cadaver
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Chungcheongnam-do
;
Hepatitis B*
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Hepatitis*
;
Herpesvirus 1, Cercopithecine
;
Humans
;
Korea
;
Liver Transplantation*
;
Liver*
;
Living Donors*
;
Prevalence
;
Tissue Donors*
;
Transplants
10.Gender-specific Association between Polymorphism of Vascular Endothelial Growth Factor (VEGF 936C>T) Gene and Patients with Stomach Cancer.
Su Jin BAE ; Dae Ho AHN ; Sung Pyo HONG ; Haeyoun KANG ; Seong Gyu HWANG ; Doyeun OH ; Nam Keun KIM
Yonsei Medical Journal 2008;49(5):783-791
PURPOSE: Angiogenesis plays an important role in the growth, progression, and metastasis of tumors. Vascular endothelial growth factor (VEGF) overexpression has been associated with advanced stage and poor survival in several cancers. We investigated the present case-control study to determine whether there is an association between the VEGF 936C>T polymorphism and stomach cancer. PATIENTS AND METHODS: The association of functional single nucleotide polymorphisms (SNPs) of the VEGF gene with stomach cancer development was evaluated in a case-control study of 154 Korean stomach cancer patients. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: Our results revealed significant association of T allele-bearing genotypes with increased risk for stomach cancer development. Genotype frequencies of the VEGF 936C>T polymorphisms were significantly different between patient and control groups (CT, AOR: 2.007, 95% CI: 1.277-3.156, TT, AOR: 4.790, 95% CI: 1.174-19.539, CT+TT, AOR: 2.147, 95% CI: 1.382-3.337). When stratified by gender and age, genotype frequencies were significantly different for stomach cancer in women and in patients younger than 55 years (in women, CT, OR: 3.049, 95% CI: 1.568-5.930, CT+TT, OR: 3.132, 95% CI: 1.638-5.990; in < 55 years, CT, OR: 3.306, 95% CI: 1.413-7.732, CT+TT, OR: 3.967, 95% CI: 1.729-9.104). In addition, this association partially remained in cases with intestinal and diffuse-type stomach cancer. CONCLUSION: Our present study suggests that the VEGF 936C>T polymorphism is a susceptibility factor for stomach cancer, at least in Korean. These observations, however, require further confirmation by a larger multi-ethnic study.
Adult
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Aged
;
Aged, 80 and over
;
Case-Control Studies
;
Female
;
Genotype
;
Humans
;
Male
;
Middle Aged
;
*Polymorphism, Genetic
;
Sex Factors
;
Stomach Neoplasms/*genetics
;
Vascular Endothelial Growth Factor A/*genetics