1.The role of hydroxyl radical in the pathogenetic mechanism of endotoxin-induced acute lung injury in rats.
Young Soo SHIM ; Chul Gyu YOO ; Young Whan KIM ; Sung Koo HAN ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1992;39(2):120-130
No abstract available.
Acute Lung Injury*
;
Animals
;
Hydroxyl Radical*
;
Rats*
2.Screening for early detection of lung cancer: results from Seoul National University Hospital.
Yong Chol HAN ; Chul Gyu YOO ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM
Tuberculosis and Respiratory Diseases 1991;38(2):119-127
No abstract available.
Lung Neoplasms*
;
Lung*
;
Mass Screening*
;
Seoul*
3.Clinical characteristics of diffuse panbronchiolitis.
Young Whan KIM ; Chul Gyu YOO ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1992;39(1):28-34
No abstract available.
4.The role of pulmonary capillary pressure in the oxygen free radical- induced acute lung injury.
Chul Gyu YOO ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1992;39(6):474-483
No abstract available.
Acute Lung Injury*
;
Capillaries*
;
Oxygen*
5.The Clinical Study of 10 Cases of Tsutsugamushi Fever.
Dong Gyu LEE ; Sung Hak KIM ; Byung Keun HAN ; Kyung Ho LEE ; Cheol Hee HWANG ; Moon Ki CHO
Journal of the Korean Pediatric Society 1994;37(5):689-694
In Korean, there has been an increasing concern on rickettsiosis as a possile common cause of unknown febrile illness since Tsutsugamushi fever among koreans was reported first in 1986. We experienced 10 cases of Tsutsugamushi fever ocurring in the Mokpo area during the period of 3 months (Oct, to Dcc.) in 1990, which were diagnosed clinically and serologically by indirect immunofluorescent antibody test. The following results were obtained. The most frequent symptoms were fever (100%), headache (90%), chill (60%), conjunctival injection, and lymphadenopathy. Common laboratory findings were leukopenia (WBC<5000/mm3 30%), elevated ESR (>20mm/hr, 30%), positive CRP (60%), and elevated Alt/AST. Antibody titers against R. tsutsugamushi ranged from 1:80 to 1:1,280, but they showed no antibody reaction to Hantaan virus and leptospira. All patients showed good response to antibiotic therapy with chloramphenicol.
Chloramphenicol
;
Fever
;
Hantaan virus
;
Headache
;
Humans
;
Jeollanam-do
;
Leptospira
;
Leukopenia
;
Lymphatic Diseases
;
Scrub Typhus*
6.Inguinal hernia developed after radical retropubic surgery for prostate cancer.
Choon Sik CHUNG ; Gyu Young JEONG ; Seung Han KIM ; Dong Keun LEE
Journal of the Korean Surgical Society 2013;85(4):175-179
PURPOSE: In this retrospective study, we aimed to compare the clinical characteristics of inguinal hernia developed after radical retropubic surgery for prostate cancer to the hernia without previous radical prostatectomy. METHODS: Twenty-three patients (group A) who had radical retropubic surgery for prostate cancer underwent laparoscopic or open tension-free inguinal hernia repair from March 2007 to February 2011. Nine hundred and forty patients (group B) without previous radical retropubic surgery received laparoscopic or tension-free open hernia operation. RESULTS: Group A was older than group B (mean +/- standard deviation, 69.6 +/- 7.2 vs. 54.1 +/- 16.1; P < 0.001). Right side (73.9%) and indirect type (91.3%) in group A were more prevalent than in group B (51.5% and 69.4%, respectively) with statistic significance (P = 0.020 and P = 0.023). The rate of laparoscopic surgery in group B (n = 862, 91.7%) was higher than in group A (n = 14, 64.3%, P < 0.001). In comparing perioperative variables between the two groups, operative time (49.4 +/- 23.5 minutes) and hospital stay (1.9 +/- 0.7 days) in group A were longer than in group B (38.9 +/- 16.9, 1.1 +/- 0.2; P = 0.046 and P < 0.001, respectively) and pain score at 7 days in group A was higher than in group B (3.1 +/- 0.7 vs. 2.3 +/- 1.0, P < 0.001). Postoperative recurrence rate was not significantly different between the two groups. CONCLUSION: Inguinal hernia following radical retropubic surgery for prostate cancer was predominantly right side and indirect type with statistic significance compared to hernias without previous radical prostatectomy.
Hernia
;
Hernia, Inguinal
;
Humans
;
Laparoscopy
;
Length of Stay
;
Operative Time
;
Prostate
;
Prostatectomy
;
Prostatic Neoplasms
;
Recurrence
;
Retrospective Studies
7.Definition, Pathogenesis, and Natural Progress of Non-alcoholic Fatty Liver Disease.
Journal of Korean Diabetes 2014;15(2):65-70
Non-alcoholic fatty liver disease (NAFLD) is emerging as a world-wide health problem and is currently recognized as a hepatic manifestation of metabolic syndrome. It is an umbrella term to describe a wide range of diseases from simple steatosis to non-alcoholic hepatosteatosis (NASH) and NSAH-related liver cirrhosis. NAFLD is mainly associated with insulin resistance which allows increased free fatty acid (FFA) flux to the liver by increasing lipolysis from adipose tissue, triggering macrophage/immune activation, decreasing skeletal muscle glucose uptake, and increasing de novo lipogenesis. Increased FFA pool in the liver, in turn, increases lipotoxic intermediates, such as ceramides, diacylglycerols, and lysophosphatidylcholines, which are responsible for mitochondrial dysfunction and endoplasmic reticulum stress, resulting in inflammation of the liver. When inflammation is severe enough to affect stellate cells, hepatic fibrosis can be induced.
Adipose Tissue
;
Ceramides
;
Diglycerides
;
Endoplasmic Reticulum Stress
;
Fatty Liver*
;
Fibrosis
;
Glucose
;
Hepatic Stellate Cells
;
Inflammation
;
Insulin Resistance
;
Lipogenesis
;
Lipolysis
;
Liver
;
Liver Cirrhosis
;
Lysophosphatidylcholines
;
Muscle, Skeletal
;
Obesity
8.PIVKA-II ; The significance as a new numor marker for hepatocellular carcinoma.
Seong Ho CHOI ; Young Min SHIN ; Sang Hyun KIM ; Seung Keun PARK ; Hun Jig LEE ; Dae Han KANG ; Mong CHO ; Ung Suk YANG ; Han Gyu MOON
Korean Journal of Medicine 1993;45(1):69-76
No abstract available.
Carcinoma, Hepatocellular*
9.Clinical study of dark-blue pigmentation in the bronchial mucosa.
In Won PARK ; Chul Gyu YOO ; O Jung KWON ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1991;38(3):280-286
No abstract available.
Mucous Membrane*
;
Pigmentation*
10.Clinical Effect of Low-dose Long-term Erythromycin on Diffuse Panbronchiolitis.
Young Whan KIM ; Gye Young PARK ; Chul Gyu YOO ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1994;41(2):127-134
BACKGROUND: Diffuse panbronchiolitis(DPB) is a chronic inflammatory lung disease of unknown etiology which has characteristic clinical, radiological and pathological features, and is distinguished from bronchial asthma, chronic bronchitis, pulmonary emphysema, bronchiectasis, or alveolitis. Clinically, patients with DPB have chronic cough, purulent sputum, exertional dyspnea, and finally respiratory failure. Until a few years ago, the prognosis of DPB had been thought to be very grave, because there had been no effective treatment for the disease. But recently, low-dose long-term erythromycin was found to be very effective on DPB. Even though DPB is prevalent in Japan, and is known to be rare outside of Japan, we have already reported the clinical features of 16 DPB cases in Korea. We tried low-dose long-term erythromycin on DPB patients and analyzed the clinical effect of erythromycin. METHODS: We analyzed the changes of subjective symptoms, physical signs, pulmonary function tests and chest X-rays on 14 DPB patients with more than 6 months erythromycin treatment during the period from September 1989 to August 1992 in Seoul National University Hospital. RESULTS: 1) Subjective symptoms improved in all patients within 2-3 months, and 54.5% of the patients shorted no symptom after one year of treatment. 2) Crackles and wheezing decreased in 92.9% of the patients after 3 months and completely disappeared in 63.5% of the Patients after one year of treatment. 3) FVC and FEV1 increased remarkably during the first 3 months, and slowly increased thereafter, reaching normal level after one year of treatment. 4) Small nodular lesions on chest X-ray decreased in all patients, and chest PA was normal in 36.4% of the patients after one year of treatment. 5) There was side effect in one patient, stopping medication because of dyspepsia. One patient stopped medication because of no symptom after 16 months of treatment, but her symptom recurring after one month, improving again after retreatment. CONCLUSION: Low-dose long-term erythromycin showed ramarkable effectiveness on DPB. Further studies are needed on the mechanism of the drug and the duration of the treatment.
Asthma
;
Bronchiectasis
;
Bronchitis, Chronic
;
Cough
;
Dyspepsia
;
Dyspnea
;
Erythromycin*
;
Humans
;
Japan
;
Korea
;
Lung Diseases
;
Prognosis
;
Pulmonary Emphysema
;
Respiratory Function Tests
;
Respiratory Insufficiency
;
Respiratory Sounds
;
Retreatment
;
Seoul
;
Sputum
;
Thorax