Localized amnesia is characterized by a failure to recall events that occurred during a circumscribed period of time. Localized amnesia is the most common type of dissociative amnesia. It is assumed that this is a disorder of memory retrieval. Recent neuroimaing studies reported that posterior cingulate cortex may play a important role in memory(autobiographical) retrieval. The authors reported a case of localized amnesia with mass on left posterior cingulate cortex.
Amnesia* ; Gyrus Cinguli* ; Humans ; Memory

PURPOSE: To compare T2 relaxation times (T2) in the cingulate cortex, amygdaloid body, hippocampal body, and insular cortex between 1.5T and 3.0T MR imagers. MATERIALS AND METHODS: Twelve healthy volunteers underwent FLAIR and CPMG imaging perpendicular to the hippocampal body at both 3.0T and 1.5T. T2 was measured in the cingulate cortex, amygdaloid body, hippocampal body, and insular cortex. The T2 relaxation time ratios of the cingulate cortex, insular cortex, and amygdaloid body to the hippocampal body were compared between 1.5T and 3.0T. RESULTS: The mean T2 of the cingulate cortex, amygdaloid body, hippocampal body, and insular cortex at 1.5T were 109.5+/-3.1, 117.0+/-7.1, 114.7+/-2.4, and 111.3+/-2.4, respectively; 99.7+/-3.8, 100.7+/-4.3, 97.9+/-3.4, and 96.2+/-2.0, respectively, at 3.0T. Percentage changes of T2 in the cingulate cortex, insular cortex, amygdaloid body, and hippocampal body at 3.0T with respect to those at 1.5T were -8.9%, -13.5%, -14.6%, and -13.5%, respectively. The mean T2 ratios of the cingulate gyrus, insular cortex, and amygdaloid body to the hippocampal body at 1.5T and 3.0T were 0.96 and 1.02 (p=0.003); 1.02 and 1.03 (p>0.05); 0.97 and 0.98 (p>0.05), respectively. CONCLUSION: T2 decrease in the cingulate cortex was less than the amygdaloid body, insular cortex, and hippocampal body at 3.0T. The mean T2 ratio of the cingulate gyrus to the hippocampal body was significantly different between 1.5T and 3.0T.
Amygdala ; Brain ; Gyrus Cinguli ; Hippocampus ; Relaxation

Ictal crying has been associated with ictal activities in the medial frontal or medial temporal area of the nondominant hemisphere. We applied current-source analysis to the interictal spikes of a patient with episodes of ictal crying without sad feelings, but fear sensation. The current sources were in the medial frontal area of both cerebral hemispheres, the temporal area and the posterior cingulate gyrus of the right hemisphere.
Cerebrum ; Crying ; Gyrus Cinguli ; Humans ; Sensation

PURPOSE: The expression of c-Fos protein has been shown to be a useful marker for elevated levels of neuronal activity generated in the brain following different stimuli, including seizures. This study was conducted to investigate distribution and numbers of neurons where dentate and cingulate gyrus become activated following pentylenetetrazol-induced seizures by means of expression patterns of c-Fos protein. METHODS: Rats were sacrificed at increasing times(1 hour, 2 hours, 8 hours, 1 day, 4 days and 7 days) after pentylenetetrazol-induced seizure. Rat brains were removed and sliced in rat brain matrix. Brain slices were coronal sectioned at interaural 5.70-6.70mm. Serial sections were immunohistochemically reacted with polyclonal c-Fos antibody. The distribution and numbers of c-Fos protein immunoreactive neurons in dentate gyrus and cingulate gyrus were examined and analyzed statistically with Mann-Whitney U test. RESULTS: The numbers of c-Fos protein immunoreactive neurons in dentate gyrus peaked at 1 hours and reached almost normal conditions at 7 days after seizure. Also, same patterns were occurred in cingulate gyrus. Concentration value that pentylenetetrazol can induce was different from each animals and c-Fos immunoreactive cells were various kinds of neurons. CONCLUSION: Higher numbers of c-Fos protein immunoreactive neurons were found in dentate and cingulate gyrus at the same times after seizure. These findings suggest that neurons of dentate and cingulate gyrus play a crucial role in seizure onset following pentylenetetrazol-induced seizure.
Animals ; Brain* ; Dentate Gyrus ; Gyrus Cinguli ; Neurons ; Pentylenetetrazole ; Rats* ; Seizures*

OBJECTIVES: Virtual reality has been increasingly used in the psychiatric field. Presence, the sense of "being there," is an essential concept in terms of the effectiveness of the virtual reality. The present study aimed to investigate the characteristics of the presence-related brain regions in patients with schizophrenia. METHODS: Using fMRI, brain activities were measured while performing the virtual reality tasks in fifteen healthy normal subjects and fifteen patients with schizophrenia. The tasks consisted of listening to some stories and inferring the content of the previous events. Ambiguous information was given for the experimental task, whereas clear information was given for the control task. Correlations between the image contrast values and the presence scores were analyzed. RESULTS: The presence-related brain regions in healthy controls were identified in the two discrete region groups that could be referred to as the cognitive neural correlates and the perceptual neural correlates. The former included the anterior cingulate, the left inferior temporal gyrus, the right lingual gyrus, and the right cuneus, whereas the latter consisted of the right posterior cingulate, the left lingual gyrus and the right fusiform gyrus. Compared with healthy controls, regional correlation patterns were different in patients with schizophrenia, including that the posterior cingulate had significant correlations. CONCLUSION: These results suggest that patients with schizophrenia utilize perceptual apparatus for the presence more than the cognitive aspect. A peculiar pattern of the presence in schizophrenia may be related to increased correlations between the posterior cingulate and other brain regions.
Brain ; Gyrus Cinguli ; Humans ; Magnetic Resonance Imaging ; Schizophrenia

OBJECTIVE: Although cingulotomy has been applied to patients with affective disorders more frequently, there are numerous reports of its use for the control of severe pain. The goal of this study was to investigate the role of stereotactic bilateral anterior cingulotomy for intractable cancer pain. METHOD:Between January and June, 2000, we underwent stereotactic bilateral anterior cingulotomy in 6 patients for intractable cancer pain with poor response to opioids. The patients were suffering from widespread musculoskeletal or visceral pain. We made four lesions along the two tracks on either side of the cingulate cortex. Result: In all patients, pain reliefs after cingulotomy were dramatic and immediate. Five out of six patients did not require any opioids and one patient could reduce dose of opioids. There were no deaths or serious complications related to the procedure. CONCLUSION: These results suggested that a bilateral anterior cingulotomy might be useful method to control intractable cancer pain associated with the widespread metastatic disease. To provide rationale of bilateral anterior cingulotomy in intractable cancer pain, the theoretical mechanisms and role of bilateral anterior cingulotomy are discussed, along with our surgical techniques and the course of our patients.
Analgesics, Opioid ; Gyrus Cinguli ; Humans ; Mood Disorders ; Visceral Pain

OBJECTIVES: Characteristic symptoms, including hyperactivity and easy distractibility, in children with attention-deficit hyperactivity disorder (ADHD) suggest that their brain status, even at rest, might differ from that of healthy children. This study was conducted in order to determine whether resting state brain activity is compromised in medication-naive children with ADHD. METHODS: Twenty medication-naive children with ADHD (mean age 10.3+/-2.5) and 28 age- and gender-matched healthy volunteers (mean age 10.3+/-2.0) underwent measurements for resting state brain activity using functional magnetic resonance imaging (fMRI). Among resting state related-independent components (RSICs) extracted from fMRI data using independent component analysis, a significant difference in RSICs was observed between groups, using a mixed Gaussian/gamma model. RESULTS: Except for IQ, which was higher in the healthy control group, no demographic difference was observed between the two groups (p<.001). Significantly less activation of one RSIC, which includes the bilateral precuneus/posterior cingulate cortex, occipito-temporal junction, and anterior cingulate cortex, was observed in the ADHD group, compared with the control group (p<.05). CONCLUSION: An abnormal RSIC, posterior default mode network (DMN), was observed in the medication-naive ADHD group. Results of our study suggest that abnormality of posterior DMN is one of the main pathophysiologies of ADHD.
Brain ; Child ; Gyrus Cinguli ; Humans ; Magnetic Resonance Imaging

People as third-party observers, without direct self-interest, may punish norm violators to maintain social norms. However, third-party judgment and the follow-up punishment might be susceptible to the way we frame (i.e., verbally describe) a norm violation. We conducted a behavioral and a neuroimaging experiment to investigate the above phenomenon, which we call the "third-party framing effect". In these experiments, participants observed an anonymous perpetrator deciding whether to keep her/his economic benefit while exposing a victim to a risk of physical pain (described as "harming others" in one condition and "not helping others" in the other condition), then they had a chance to punish that perpetrator at their own cost. Our results showed that the participants were more willing to execute third-party punishment under the harm frame compared to the help frame, manifesting a framing effect. Self-reported anger toward perpetrators mediated the relationship between empathy toward victims and the framing effect. Meanwhile, activation of the insula mediated the relationship between mid-cingulate cortex activation and the framing effect; the functional connectivity between these regions significantly predicted the size of the framing effect. These findings shed light on the psychological and neural mechanisms of the third-party framing effect.
Empathy ; Female ; Gyrus Cinguli ; Humans ; Neuroimaging ; Pain ; Punishment/psychology*

This study was conducted to Identify the effects of diazepam on stress-induced c-fos expression In rat brain. The rats were divided into 4 groups according to injection agents [0.9% isotonic saline 1ml, diazepam(5 mg/kg)] and restraint stress, respectively. Saline or diazepam was injected into the peritoneum of rats 10 minutes before the restraint groups were restrained in a wire chamber. Fos-immunoreactive neurons were calculated in the hippocampal area CA2, dentate gyrus, amygdalohippocampal area, paraventricular nucleus, ventral lateral geniculate nucleus, supramammillary nucleus, temporal cortex area 3, occipital cortex area 2, piriform cortex, and cingulate cortex area 3. The results were as follows: 1) In the hippocampal formation including hippocampal area CA2 and dentate gyrus, Fos expression increased significantly in the saline-injected restraint animals than in any other groups. A two-way factorial ANOVA retreated a significant erects of stress and diazepam, and a significant stress by diazepam interaction. 2) In amygdalohippocampal area, Fos expression increased significantly in the saline-injected restraint animals than in diazepam-injected animals. A two-way factorial ANOVA revealed a significant effects of stress and diazepam, but no significant Interaction of stress and diazepam. 3) In paraventricular nucleus, Fos expression increased significantly in the saline-injected restraint animals than in saline-Injected animals and diazepam-injected animals. A two-way factorial ANOVA revealed a significant effects of stress, no significant effects of diazepam, and no significant Interaction of stress and diazepam. 4) In ventral lateral geniculate nucleus, Fos expression Increased significantly in the saline-injected restraint animals than in diazepam-Infected animals and diazepam-injected restraint animals. A two-way factorial ANOVA revealed a significant effects of diazepam, no significant effects of stress, and no significant interaction of stress and diazepam. 5) In supramammillary nucleus, temporal cortex area 3, occipital cortex area 2, piriform cortex, and cingulate cortex area 3, there was no significant difference of Fos expression in each group. A two-way factorial ANOVA revealed no significant effects of stress and diazepam, and no significant interaction of stress and diazepam. These results suggest that the hippocampal formation is involved in the response to the stress and the tension reduction effect of diazepam.
Animals ; Brain* ; Dentate Gyrus ; Diazepam* ; Gyrus Cinguli ; Hippocampus ; Neurons ; Paraventricular Hypothalamic Nucleus ; Peritoneum ; Rats*

This study was aimed to clarify the effects of systemic kainic acid (KA) administration (10 mg/kg i.p.) on somatostatin containing neurons, and to examine the distribution of somatostain immunoreactive neurons in the cerebral cortex of the rats. Animals were sacrificed at three time points at the two, six, and ten days after the injection of KA. Thirty-six rats were observed by using the free-floating immunohistochemical method (modified ABC method). The results were as follows: 1) In the anterior and posterior cingulate cortex, somatostatin immunoreactive neurons were not observed in 2,6,10days after treatment of KA including control group except Cg 1 showing some somatostatin immunoreactive neurons in 10days and control groups. 2) In the insular cortex, somatostatin immunoreactive neurons also were not observed in any groups except AIV showing few somatostatin immunoreactive neurons in control group. 3) In the perirhinal cortex, few somatostatin immunoreactive neurons were observed in 2 days and 6 days groups. In control group, a number of somatostatin immunoreactive neurons observed. 4) A strong decrease of somatostatin immunoreactive neurons were observed in the frontal, arietal, temporal and occipital cortex 2 days after treatment of KA. Initially decreased somatostatin immunoreactive neurons had recovered to control 10 days after treatment. 5) Distribution of the somatostatin immunoreactive neurons was observed marked difference according to the cortical areas. Somatostatin immunoreactive neurons in isocortex were more increased in number than the allcotex by control study. The changes in somatostatin immunoreactive neurons after systemic treament of KA were marked in 2 days and 6 days, but these had recovered to control 10 days the treatment of KA. It suggested the normalization of the cerebral function 10 days after seizure. According to the cerebral cortex, the different distribution of somatostatin immunoreactive neurons in number was observed.
Animals ; Cerebral Cortex* ; Gyrus Cinguli ; Kainic Acid* ; Neurons* ; Rats* ; Seizures ; Somatostatin*