No abstract available.
Nephrotic Syndrome* ; Thrombosis*

BACKGROUND: The purpose of this study was to identify the effects of Tai Chi exercise program on physical symptoms (pain, stiffness) and physical function (difficulty with physical function) related to joint, stress, depression, and sleep disturbance in middle aged women with osteoarthritis. METHODS: The study was conducted with a nonequivalent control group pretest-posttest design. Forty participants were assigned to either the experimental group (20) or control group (20). Tai Chi exercise program was administered twice a week for 12 weeks to participants in experimental group. Data were collected from October 4 to December 24, 2011 and analyzed using chi2-test and t-test. RESULTS: There were significant differences between groups in joint pain score (z=-2.029, P=0.047) of Korean-Western Ontario and McMaster University Osteoarthritis (K-WOMAC) index and depression score (z=-2.566, P=0.010). However, there were no significant differences in stiffness score and physical function score of K-WOMAC index, stress score and sleep disturbance score. CONCLUSIONS: Findings from this study indicate that Tai Chi exercise program are effective in reducing joint pain and depression in osteoarthritis women. It could be regarded as positive program for health promotion of self-care skills in middle-aged women with osteoarthritis.
Arthralgia ; Depression ; Female ; Health Promotion* ; Humans ; Joints ; Middle Aged* ; Ontario ; Osteoarthritis* ; Self Care ; Tai Ji*

BACKGROUND: The purpose of this study was to identify the effects of Tai Chi exercise program on physical symptoms (pain, stiffness) and physical function (difficulty with physical function) related to joint, stress, depression, and sleep disturbance in middle aged women with osteoarthritis. METHODS: The study was conducted with a nonequivalent control group pretest-posttest design. Forty participants were assigned to either the experimental group (20) or control group (20). Tai Chi exercise program was administered twice a week for 12 weeks to participants in experimental group. Data were collected from October 4 to December 24, 2011 and analyzed using chi2-test and t-test. RESULTS: There were significant differences between groups in joint pain score (z=-2.029, P=0.047) of Korean-Western Ontario and McMaster University Osteoarthritis (K-WOMAC) index and depression score (z=-2.566, P=0.010). However, there were no significant differences in stiffness score and physical function score of K-WOMAC index, stress score and sleep disturbance score. CONCLUSIONS: Findings from this study indicate that Tai Chi exercise program are effective in reducing joint pain and depression in osteoarthritis women. It could be regarded as positive program for health promotion of self-care skills in middle-aged women with osteoarthritis.
Arthralgia ; Depression ; Female ; Health Promotion* ; Humans ; Joints ; Middle Aged* ; Ontario ; Osteoarthritis* ; Self Care ; Tai Ji*

We report a case of penile lymphangioma circumscriptum developed in a 22- year-old male soldier. Rice-sized papule on glans penis was noted at birth and progressed to yellow straw-colored, peanut-sized, asymptomatic grouped papulovesicles resembling frog spawn. The predilection sites of lymphangioma circumscriptum are the abdomen, axilla and tongue. Glans penis is a very rare site. Histopathologic findings showed papillornatosis, hyperkeratosis and cystically dilated lymph vessels lined by a single layer of endothelial cells.
Abdomen ; Axilla ; Endothelial Cells ; Humans ; Lymphangioma* ; Male ; Military Personnel ; Parturition ; Penis ; Tongue

We report herein a case of lymphomatoid papulosis showing atypical clinical manifestations. A 54- year-old man had had recurrent erythematous necrotic papules and nodues, numbering more than 200 lesions at the most aggravated time, on the trunk, extremities, buttok, and face for the last twenty years. Recently, he complained of tender swelling on the neck, axillae, and inguinal lymph nodes accompanied by mild fever and gerneral weakness. We had performed thorough examinations including biopsy from the skin lesions, lymph node, and bone marrow to detect some evidences of transforming to malignant lymphoma, but found no evidence of malignant lymphoma except aneuploidy on DNA histogram. The patients showed proinpt response to methotrexate 10-30mg par week wit,hout showing distinct side reactions to the accurvulated dose of 780mg for the last 16 months.
Aneuploidy ; Axilla ; Biopsy ; Bone Marrow ; DNA ; Extremities ; Fever ; Humans ; Lymph Nodes ; Lymphoma ; Lymphomatoid Papulosis* ; Methotrexate ; Neck ; Skin

This study was designed to examine the effects of two antidepressant drugs on the expression of c-fos mRNA in cultured embryonic rat hippocampal neurons. The drugs used were imipramine and amitriptyline. On the fourth day of culture, hippocampal neurons were treated with variable concentrations of each drug. Competitive RT-PCR(Reverse Transcriptase-PCR) analysis was used to quantify the c-fos mRNA expression induced by each drug. Experimental results showed that acute and direct treatment with imipramine and amitriptyline with relatively low concentrations(imipramine < or =10micrometer, amitriptyline < or =10micrometer) had no inductive effect on the expression of c-fos mRNA in the rat hippocampal neurons. However, after treatment with relatively high concentrations(imipramine > or =100micrometer, amitriptyline > or =100micrometer) c-fos mRNA was not detected. These findings suggest the followings. Firstly, the action mechanisms of these drugs on the hippocampal neurons might not be mediated by c-fos but by other immediate-early genes(IEGs). Secondly, their actions may be mediated indirectly via other areas of the brain. Thirdly, the expression of c-fos might be inhibited by high concentrations of these drugs, or the high concentrations could induce cell death. Finally, though cell death remains to be confirmed, the inhibition of c-fos induction or cell death could play a role in the cognitive impairments known to be adverse effects of some antidepressants. This study is believed to be a first step toward understanding the mechanisms of learning and memory. Further studies are needed to investigate the expression of various IEGs and changes in the hippocampal neurons of rat resulting from chronic treatment with antidepressant drugs.
Amitriptyline ; Animals ; Antidepressive Agents* ; Brain ; Cell Death ; Imipramine ; Learning ; Memory ; Neurons* ; Rats* ; RNA, Messenger*

BACKGROUND: The purpose of this study was to identify the effects of Tai Chi exercise program on physical symptoms (pain, stiffness) and physical function (difficulty with physical function) related to joint, stress, depression, and sleep disturbance in middle aged women with osteoarthritis. METHODS: The study was conducted with a nonequivalent control group pretest-posttest design. Forty participants were assigned to either the experimental group (20) or control group (20). Tai Chi exercise program was administered twice a week for 12 weeks to participants in experimental group. Data were collected from October 4 to December 24, 2011 and analyzed using chi2-test and t-test. RESULTS: There were significant differences between groups in joint pain score (z=-2.029, P=0.047) of Korean-Western Ontario and McMaster University Osteoarthritis (K-WOMAC) index and depression score (z=-2.566, P=0.010). However, there were no significant differences in stiffness score and physical function score of K-WOMAC index, stress score and sleep disturbance score. CONCLUSIONS: Findings from this study indicate that Tai Chi exercise program are effective in reducing joint pain and depression in osteoarthritis women. It could be regarded as positive program for health promotion of self-care skills in middle-aged women with osteoarthritis.
Arthralgia ; Depression ; Female ; Health Promotion ; Humans ; Joints ; Middle Aged ; Ontario ; Osteoarthritis ; Self Care ; Tai Ji

BACKGROUND/AIMS: Delayed bleeding after gastric endoscopic submucosal dissection (ESD) commonly occurs within 3 days, but it may also occur after 1 week following ESD, especially in antiplatelet agent users. We evaluated the risk of delayed bleeding in post-ESD ulcers using the Forrest classification. METHODS: Registry data on the Forrest classification of post-ESD ulcers (n=371) at 1 week or 2 weeks after ESD were retrospectively evaluated. The Forrest classification was categorized into two groups: increased risk (Forrest Ia to IIc) or low risk (Forrest III). The odds ratios (ORs) were calculated using logistic regression analysis. RESULTS: Among 371 post-ESD ulcers, one ulcer (0.3%) was classified as Forrest Ib, two (0.5%) as Forrest IIa, 17 (4.6%) as Forrest IIb, 172 (46.4%) as Forrest IIc, and 179 (48.2%) as Forrest III. The proportion of increased-risk ulcers was 72.2% (140/194) at 1 week after ESD, which decreased to 29.4% (52/177) at 2 weeks after ESD (p<0.001). In the multivariate analysis, a post-ESD ulcer at 1 week after ESD (OR, 7.54), younger age (OR, 2.17), and upper/middle ulcer location (OR, 2.05) were associated with increased-risk ulcers. CONCLUSIONS: One week after ESD, ulcers still have an increased risk of bleeding when assessed using the Forrest classification. This risk should be considered when resuming antiplatelet therapy.
Classification* ; Hemorrhage* ; Logistic Models ; Multivariate Analysis ; Odds Ratio ; Platelet Aggregation Inhibitors* ; Retrospective Studies ; Stomach Neoplasms ; Ulcer

BACKGROUND/AIMS: Managing breakthrough pain (BTP) is important for many cancer patients because of the rapid onset and unpredictable nature of the pain episodes. Fentanyl buccal tablets (FBTs) are a rapid-onset opioid indicated for BTP management. However, FBT titration is needed to optimize BTP management. In this study, we aimed to evaluate the safety and efficacy of initiating 200 μg FBTs in Korean cancer patients. METHODS: A retrospective analysis of medical records was performed on all advanced cancer patients treated with FBTs for BTP between October 2014 and July 2015. Patients who received initial doses of 200 μg FBTs for at least 3 days and cases in which FBT was available at doses of 200, 400, and 800 μg were included. RESULTS: A total of 56 patients with a median age of 62 years (range, 32 to 80) were analyzed, 61% of whom were male. The median and mean values of morphine equivalent daily doses were 60 mg/day (range, 15 to 540) and 114.8 ± 124.8 mg/day, respectively. The most frequent effective doses of FBT were 200 μg (41 patients, 74%) and 400 μg (12 patients, 21%). Three patients (5%) could not tolerate 200 μg of FBT and discontinued treatment. Nausea, vomiting, somnolence, and dizziness were the most frequent treatment-related adverse events (AEs), and all AEs were grade 1 (mild) or 2 (moderate). CONCLUSIONS: FBT at the initial 200 μg dosage was well-tolerated and effective as a BTP management strategy in Korean cancer patients. Further prospective studies are needed to determine appropriate initiating doses of FBT in Korean patients with opioid tolerance.
Analgesics, Opioid ; Breakthrough Pain ; Dizziness ; Fentanyl* ; Humans ; Male ; Medical Records ; Morphine ; Nausea ; Prospective Studies ; Retrospective Studies* ; Tablets* ; Vomiting

PURPOSE: Increasing evidence suggests that polymorphisms in innate immunity genes are associated with Helicobacter pylori-induced inflammation and may influence susceptibility in developing noncardia gastric cancer. Therefore, we investigate the effect of polymorphisms of innate immunity genes and interactions with environmental factors in the Korean population. MATERIALS AND METHODS: We genotyped four polymorphisms of TLR2 (rs1898830), TLR4 (rs10983755 and rs10759932), and CD14 (rs2569190) in a case-control study of 487 noncardia gastric cancer patients and 487 sex- and age-matched healthy controls. Polytomous logistic regression models were used to detect the effects of genetic polymorphisms and environmental factors, which were stratified by the histological type of gastric cancer. RESULTS: TLR4 rs10983755 A carriers were found to have higher risk of intestinal-type noncarida gastric cancer than G homozygotes (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.01 to 1.97), but other genetic variants showed no association with the risk of noncardia gastric cancer. Among H. pylori-positive participants, smokers carrying TLR4 rs10983755 A had a higher risk of intestinal-type gastric cancer than nonsmoking TLR4 rs10983755 G homozygotes (OR, 4.28; 95% CI, 2.12 to 8.64). In addition, compared with tap water, other drinking water sources during childhood were found to be associated with the elevated risk of intestinal-type gastric cancer, and these associations were slightly stronger among TLR4 rs10983755 A carriers. CONCLUSION: The genetic polymorphisms of innate immunity genes are associated with the development of intestinal-type noncardia gastric cancer and these associations may differ in accordance to an exposure to certain environmental factors.
Case-Control Studies ; Drinking Water ; Helicobacter ; Homozygote ; Humans ; Immunity, Innate* ; Inflammation ; Logistic Models ; Polymorphism, Genetic ; Smoking ; Stomach Neoplasms* ; Water