No abstract available.
Muir-Torre Syndrome*

No abstract available.
Dermoscopy* ; Diagnosis

Not legally, arsenic has been used for various medical purposes. Chronic exposure to arsenic can induce different kinds of cutaneous diseases, including arsenic keratosis, Bowen's disease, squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and other pigment disorders. Also, arsenic induces internal malignancies, including tumors of the pulmonary and urogenital systems. To prevent these malignancies, the use of arsenics should be strictly prohibited. We describe a 72-year-old man who developed SCC in situ and BCC after chronic exposure to arsenics.
Aged ; Arsenic ; Bowen's Disease ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Humans ; Keratosis ; Urogenital System

Adult-onset Still's disease (AOSD) is a systemic inflammatory disease of an unknown etiology, and AOSD is characterized by high fever, skin rash, arthritis, lymphadenopathy, hepatomegaly, sore throat and serositis. The typical skin rash of AOSD patients is an evanescent, erythematous maculopapular lesion. There is no single diagnostic test; therefore, the diagnosis is based upon the clinical criteria. Treatment consists of anti-inflammatory medications such as aspirin, NSAIDs, corticosteroids, anti-rheumatics and immunosuppressants. We report here on a case of AOSD in which a 53 year-old female patient presented with a high fever, a typical rash, arthritis, a sore thoat and mild splenomegaly.
Adrenal Cortex Hormones ; Adult ; Anti-Inflammatory Agents, Non-Steroidal ; Arthritis ; Aspirin ; Exanthema ; Female ; Fever ; Hepatomegaly ; Humans ; Immunosuppressive Agents ; Lymphatic Diseases ; Pharyngitis ; Serositis ; Splenomegaly ; Still's Disease, Adult-Onset

Sarcoidosis is a multisystem disorder that's characterized by non-caseating granuloma that involves the lung, lymphatic system, skin, eye and other visceral organs. There are many treatment modalities such as corticosteroid, antimalarial agents and methotrexate, but only a few cases treated with isotretinoin have currently been reported. A 31-year-old male patient presented with a two month history of solitary erythematous plaque on the philtrum without other systemic symptoms. The histopathologic findings revealed several naked noncaseating granulomas in the dermis. Special staining such as PAS and AFB showed negative findings. The patient was diagnosed with cutaneous sarcoidosis, and this showed complete remission after a 4-months of therapy with oral isotretinoin (20 mg/day).
Adult ; Antimalarials ; Dermis ; Eye ; Granuloma ; Humans ; Isotretinoin ; Lip ; Lung ; Lymphatic System ; Male ; Methotrexate ; Sarcoidosis ; Skin

PURPOSE: Actinic keratosis (AK) is an incipient form of cutaneous squamous cell carcinoma (SCC). We determined if the pattern of expression of keratin-14 (K14) is a factor for tumor progression in AK and SCC. MATERIALS AND METHODS: Eighteen sections from the tissues of 16 patients were stained with anti-K14 antibody and p16(INK4a). Among the 16 patients, 4 were diagnosed with both SCC and AK at the same site, but AK developed first and SCC developed subsequently. Thus, SCC may have evolved from AK. The other 12 patients were only diagnosed with AK. RESULTS: In all of the AK and SCC tissues, basement membranes showed positive staining for K14. However, strong reactivities were shown in the spinous and granular layers and focuses of dermal invasion in the SCC tissues developed from AK. Two and 3 of the 12 AK cases had moderately positive reactions for K14 in the spinous and granular layers, respectively. Also, all SCC tissues except one had moderate-to-strong reactions in the basal, spinous, and granular layers for p16(INK4a). Two of the 12 AK cases had weak-to-moderate positive reactions in the basal, spinous, and horny layers for p16(INK4a). CONCLUSION: The results of our study advance our understanding of the pathogenesis of SCC developing from AK. The results also indicate a differential role in the control of K14 in normal epithelia, AK, and SCC. K14 expression in the spinous and granular layers may be a prognostic factor for tumor progression of AK.
Actins ; Basement Membrane ; Carcinoma, Squamous Cell ; Cyclin-Dependent Kinase Inhibitor p16 ; Humans ; Keratin-14 ; Keratosis ; Keratosis, Actinic

BACKGROUND: There is currently an increasing demand in the field of dermatology for surgical therapy for treating skin cancers, including premalignant and malignant lesions. The rhombic (often referred to as rhomboid) flap is a transposition flap that is an excellent option for reconstructing small to medium-sized defects after skin surgery. Objective: We analyzed our clinical results of using the rhombic flap for reconstruction after skin cancers, and especially in regard to the aspects of cosmesis, complete surgical excisions, recurrence and the scope of dermatosurgical care. METHODS: From July 2004 to May 2008, forty one patients who were diagnosed with non-melanoma skin cancer or benign tumor on the face, trunk and extremities were treated with a rhombic flap or its modified form for the reconstruction of primary cutaneous defects following the excision of tumor. The cases were divided into groups according to the cosmetic units and the clinical outcomes were reviewed, and cosmetic results were scored as excellent, good, fair or poor. RESULTS: Forty-two rhombic transposition flaps were done in 41 patients. Among these patients, 16 were men and 25 were woman. There were 23 cases of malignant tumor and 19 cases of premalignant and benign tumors. Thirty two cases were located on the face (12 on the cheek, 7 on the nose, 5 on the forehead and periorbital area, 2 on the mouth and 1 on the ear) and 10 cases were located on the other sites (4 on the trunk, 2 on the buttock, 2 on the finger, 1 on the arm and 1 on the leg). There was tumor recurrence in one case. The cosmetic results of reconstructions were satisfactory, and 29 cases out of the 42 (69%) cases showed good to excellent results after 6 months. CONCLUSION: Rhombic transposition flap can be a simple and good choice for reconstructing cutaneous defects on the face, trunk and extremities after skin tumor surgery. It could also be applied to the defect with limited skin laxity without tension or distortion, and it especially showed excellent and good cosmetic results in most of the cases.
Arm ; Buttocks ; Cheek ; Cosmetics ; Dermatologic Surgical Procedures ; Dermatology ; Extremities ; Female ; Fingers ; Forehead ; Humans ; Male ; Mouth ; Nose ; Recurrence ; Skin ; Skin Neoplasms

BACKGROUND: There is currently an increasing demand in the field of dermatology for surgical therapy for treating skin cancers, including premalignant and malignant lesions. The rhombic (often referred to as rhomboid) flap is a transposition flap that is an excellent option for reconstructing small to medium-sized defects after skin surgery. Objective: We analyzed our clinical results of using the rhombic flap for reconstruction after skin cancers, and especially in regard to the aspects of cosmesis, complete surgical excisions, recurrence and the scope of dermatosurgical care. METHODS: From July 2004 to May 2008, forty one patients who were diagnosed with non-melanoma skin cancer or benign tumor on the face, trunk and extremities were treated with a rhombic flap or its modified form for the reconstruction of primary cutaneous defects following the excision of tumor. The cases were divided into groups according to the cosmetic units and the clinical outcomes were reviewed, and cosmetic results were scored as excellent, good, fair or poor. RESULTS: Forty-two rhombic transposition flaps were done in 41 patients. Among these patients, 16 were men and 25 were woman. There were 23 cases of malignant tumor and 19 cases of premalignant and benign tumors. Thirty two cases were located on the face (12 on the cheek, 7 on the nose, 5 on the forehead and periorbital area, 2 on the mouth and 1 on the ear) and 10 cases were located on the other sites (4 on the trunk, 2 on the buttock, 2 on the finger, 1 on the arm and 1 on the leg). There was tumor recurrence in one case. The cosmetic results of reconstructions were satisfactory, and 29 cases out of the 42 (69%) cases showed good to excellent results after 6 months. CONCLUSION: Rhombic transposition flap can be a simple and good choice for reconstructing cutaneous defects on the face, trunk and extremities after skin tumor surgery. It could also be applied to the defect with limited skin laxity without tension or distortion, and it especially showed excellent and good cosmetic results in most of the cases.
Arm ; Buttocks ; Cheek ; Cosmetics ; Dermatologic Surgical Procedures ; Dermatology ; Extremities ; Female ; Fingers ; Forehead ; Humans ; Male ; Mouth ; Nose ; Recurrence ; Skin ; Skin Neoplasms

Congenital neurofibromatosis type 1, or Von Recklinghausen's disease is an autosomal dominant disorder characterized by neurofibroma, pigmented skin lesions (Cafe-au-lait macules), iris hamartomas and meningeal tumors, but rarely, by autonomic ganglia tumors, such as pheochromocytomas. We have experienced an intrathoracic and chest wall plexiform neurofibroma intimately contacted with collagenoma-like, dome-shaped skin lesions of type 1 neurofibromatosis, which are relatively rare and interesting, but can be regarded as typical findings in neurofibromatosis. Although intrathoracic neurogenic tumors are not uncommon, cases like ours are interesting, as the feature of collagenoma-like skin neurofibroma was very closely apposited with chest wall neurofibroma. Our case had no aypical features of malignancy and the patient was clinically followed up without recurrence.
Ganglia, Autonomic ; Hamartoma ; Humans ; Iris ; Meningeal Neoplasms ; Neurofibroma* ; Neurofibroma, Plexiform* ; Neurofibromatoses ; Neurofibromatosis 1* ; Pheochromocytoma ; Recurrence ; Skin ; Thoracic Wall* ; Thorax*

No abstract available.
Cheek