OBJECTIVE: The efficacy of two-drug combination treatment may be schedule-dependent. We investigated a simulated in-vitro interaction between taxol and doxorubicin in a Cervical cancer cell line HeLa and the role of peroxiredoxin in cytotoxicity. METHODS: Two contradicting schedules of two drugs (taxol followed by doxorubicin or vice versa) were compared each other in terms of cytotoxicity in parental HeLa cell line and the peroxiredoxin (prx)-overexpressing variant. Cytotoxic activity was determined by MTT assay. Cell cycle pertubation was evaluated by flow cytometric analysis. Protein levels were determined by western blot. RESULTS: The sequential treatment of taxol followed by doxorubicin (T-- Appointments and Schedules ; Blotting, Western ; Cell Cycle ; Cell Line ; Cell Line, Tumor* ; Cyclin D1 ; Doxorubicin ; HeLa Cells ; Humans ; Paclitaxel ; Parents ; Peroxiredoxins* ; Uterine Cervical Neoplasms

As a minor blood antigen, the Duffy blood group has 5 antigens which are Fya, Fyb, Fy3, Fy4 and Fy5. When the Duffy group is implicated in delayed transfusion reactions, one expects to find anti-Fya rather than Fyb. We experienced a case of delayed hemolytic transfusion reaction caused by anti-Fyb antibody. A 69 year-old woman was referred having had hematuria, fever, chill and jaundice 9 days after transfusion. The hemoglobin was 9.5mg/dl, reticulocyte count 1.4%, liver function test showed total bilirubin 10.8mg/dL, LDH 5,225IU/L, alkaline phosphatase 26IU/L. Indirect antiglobulin test was positive, while the direct one was negative. A delayed hemolytic transfusion reaction was suspected as patient's serum was reacted with panel cells for the antibody identification test and the anti-Fyb was finally identified. The patient recovered without specific treatment. There were no severe complication and sequele.It appears to be the first reported case of hemolytic transfusion reaction caused by anti-Fyb in Korea.
Aged ; Alkaline Phosphatase ; Bilirubin ; Blood Group Incompatibility ; Coombs Test ; Female ; Fever ; Hematuria ; Humans ; Jaundice ; Korea ; Liver Function Tests ; Reticulocyte Count

Objective: This study compared adaptive functioning measured by the Korean version of Vineland Adaptive Behavior Scales, Second Edition (K-VABS-II), in preschool children with developmental disabilities (DD) and those with typical development (TD). We also examined the correlation of K-VABS-II adaptive profiles with developmental and behavioral assessments. Methods: Two hundred preschool children (73 females and 127 males, mean age 54.7±9.1 months) were recruited from special educational centers, community-based daycare centers, and kindergartens. Eighty-one with DD comprising 61 with autism spectrum disorder, 63 with intellectual disability, 12 with language disorder, and 119 with TD were included. Their developmental profiles were measured by the Psychoeducational Profile-Revised (PEP-R), Preschool Receptive-Expressive Language Scale (PRES), K-VABS-II, Social Responsiveness Scale (SRS), and the Korean version of the Childhood Autism Rating Scale (K-CARS). The parent completed the Child Behavior Checklist (CBCL), and Aberrant Behavior Checklist (ABC). Results: The K-VABS-II Adaptive Behavior Composite and all domain scores of K-VABS-II differed significantly between children with DD and TD (all p<0.001). In most domains, K-VABS-II had moderate-to-strong correlations with PEP-R, PRES, K-CARS, and SRS. The Maladaptive Behavior Index domain of K-VABS-II had moderate correlations with behavioral assessments, including CBCL and ABC. Conclusion These findings suggest that K-VABS-II is useful in evaluating developmental levels and adaptive and maladaptive behaviors of preschool children with DD. K-VABS-II also had significant correlations with cognitive, language, social, and behavioral assessments.

Objective: This study compared adaptive functioning measured by the Korean version of Vineland Adaptive Behavior Scales, Second Edition (K-VABS-II), in preschool children with developmental disabilities (DD) and those with typical development (TD). We also examined the correlation of K-VABS-II adaptive profiles with developmental and behavioral assessments. Methods: Two hundred preschool children (73 females and 127 males, mean age 54.7±9.1 months) were recruited from special educational centers, community-based daycare centers, and kindergartens. Eighty-one with DD comprising 61 with autism spectrum disorder, 63 with intellectual disability, 12 with language disorder, and 119 with TD were included. Their developmental profiles were measured by the Psychoeducational Profile-Revised (PEP-R), Preschool Receptive-Expressive Language Scale (PRES), K-VABS-II, Social Responsiveness Scale (SRS), and the Korean version of the Childhood Autism Rating Scale (K-CARS). The parent completed the Child Behavior Checklist (CBCL), and Aberrant Behavior Checklist (ABC). Results: The K-VABS-II Adaptive Behavior Composite and all domain scores of K-VABS-II differed significantly between children with DD and TD (all p<0.001). In most domains, K-VABS-II had moderate-to-strong correlations with PEP-R, PRES, K-CARS, and SRS. The Maladaptive Behavior Index domain of K-VABS-II had moderate correlations with behavioral assessments, including CBCL and ABC. Conclusion These findings suggest that K-VABS-II is useful in evaluating developmental levels and adaptive and maladaptive behaviors of preschool children with DD. K-VABS-II also had significant correlations with cognitive, language, social, and behavioral assessments.

Objective: This study compared adaptive functioning measured by the Korean version of Vineland Adaptive Behavior Scales, Second Edition (K-VABS-II), in preschool children with developmental disabilities (DD) and those with typical development (TD). We also examined the correlation of K-VABS-II adaptive profiles with developmental and behavioral assessments. Methods: Two hundred preschool children (73 females and 127 males, mean age 54.7±9.1 months) were recruited from special educational centers, community-based daycare centers, and kindergartens. Eighty-one with DD comprising 61 with autism spectrum disorder, 63 with intellectual disability, 12 with language disorder, and 119 with TD were included. Their developmental profiles were measured by the Psychoeducational Profile-Revised (PEP-R), Preschool Receptive-Expressive Language Scale (PRES), K-VABS-II, Social Responsiveness Scale (SRS), and the Korean version of the Childhood Autism Rating Scale (K-CARS). The parent completed the Child Behavior Checklist (CBCL), and Aberrant Behavior Checklist (ABC). Results: The K-VABS-II Adaptive Behavior Composite and all domain scores of K-VABS-II differed significantly between children with DD and TD (all p<0.001). In most domains, K-VABS-II had moderate-to-strong correlations with PEP-R, PRES, K-CARS, and SRS. The Maladaptive Behavior Index domain of K-VABS-II had moderate correlations with behavioral assessments, including CBCL and ABC. Conclusion These findings suggest that K-VABS-II is useful in evaluating developmental levels and adaptive and maladaptive behaviors of preschool children with DD. K-VABS-II also had significant correlations with cognitive, language, social, and behavioral assessments.

Objective: This study compared adaptive functioning measured by the Korean version of Vineland Adaptive Behavior Scales, Second Edition (K-VABS-II), in preschool children with developmental disabilities (DD) and those with typical development (TD). We also examined the correlation of K-VABS-II adaptive profiles with developmental and behavioral assessments. Methods: Two hundred preschool children (73 females and 127 males, mean age 54.7±9.1 months) were recruited from special educational centers, community-based daycare centers, and kindergartens. Eighty-one with DD comprising 61 with autism spectrum disorder, 63 with intellectual disability, 12 with language disorder, and 119 with TD were included. Their developmental profiles were measured by the Psychoeducational Profile-Revised (PEP-R), Preschool Receptive-Expressive Language Scale (PRES), K-VABS-II, Social Responsiveness Scale (SRS), and the Korean version of the Childhood Autism Rating Scale (K-CARS). The parent completed the Child Behavior Checklist (CBCL), and Aberrant Behavior Checklist (ABC). Results: The K-VABS-II Adaptive Behavior Composite and all domain scores of K-VABS-II differed significantly between children with DD and TD (all p<0.001). In most domains, K-VABS-II had moderate-to-strong correlations with PEP-R, PRES, K-CARS, and SRS. The Maladaptive Behavior Index domain of K-VABS-II had moderate correlations with behavioral assessments, including CBCL and ABC. Conclusion These findings suggest that K-VABS-II is useful in evaluating developmental levels and adaptive and maladaptive behaviors of preschool children with DD. K-VABS-II also had significant correlations with cognitive, language, social, and behavioral assessments.

Objective: This study compared adaptive functioning measured by the Korean version of Vineland Adaptive Behavior Scales, Second Edition (K-VABS-II), in preschool children with developmental disabilities (DD) and those with typical development (TD). We also examined the correlation of K-VABS-II adaptive profiles with developmental and behavioral assessments. Methods: Two hundred preschool children (73 females and 127 males, mean age 54.7±9.1 months) were recruited from special educational centers, community-based daycare centers, and kindergartens. Eighty-one with DD comprising 61 with autism spectrum disorder, 63 with intellectual disability, 12 with language disorder, and 119 with TD were included. Their developmental profiles were measured by the Psychoeducational Profile-Revised (PEP-R), Preschool Receptive-Expressive Language Scale (PRES), K-VABS-II, Social Responsiveness Scale (SRS), and the Korean version of the Childhood Autism Rating Scale (K-CARS). The parent completed the Child Behavior Checklist (CBCL), and Aberrant Behavior Checklist (ABC). Results: The K-VABS-II Adaptive Behavior Composite and all domain scores of K-VABS-II differed significantly between children with DD and TD (all p<0.001). In most domains, K-VABS-II had moderate-to-strong correlations with PEP-R, PRES, K-CARS, and SRS. The Maladaptive Behavior Index domain of K-VABS-II had moderate correlations with behavioral assessments, including CBCL and ABC. Conclusion These findings suggest that K-VABS-II is useful in evaluating developmental levels and adaptive and maladaptive behaviors of preschool children with DD. K-VABS-II also had significant correlations with cognitive, language, social, and behavioral assessments.