1.Complete Atrioventricular Block in an Adolescent With Rheumatic Fever.
Korean Circulation Journal 2009;39(3):121-123
Rheumatic fever is an acute inflammatory sequela following a group A, beta-hemolytic streptococcal infection. Rheumatic fever is characterized by polyarthritis, carditis, chorea, subcutaneous nodules, and erythema marginatum as the major diagnostic criteria. Rarely, advanced heart block may also occur. A 13-year-old boy was admitted to the Pediatric Department for evaluation and management of complete atrioventricular block. The patient had exertional dyspnea for 1 month. Based on the findings of mitral regurgitation, fever, elevated acute phase reactants, and a high antistreptolysin O titer, the patient was diagnosed with rheumatic fever. A benzathine penicillin injection was administered, as well as salicylate therapy. On the 5th day of hospitalization, the electrocardiogram revealed a normal sinus rhythm with a 1st degree atrioventricular block. After discharge, the electrocardiogram normalized with the monthly penicillin injections. Herein we report a case of complete atrioventricular block associated with rheumatic fever. The heart block resolved without specific cardiac treatment, other than a non-steroidal anti-inflammatory medication.
Acute-Phase Proteins
;
Adolescent
;
Antistreptolysin
;
Arthritis
;
Atrioventricular Block
;
Chorea
;
Dyspnea
;
Electrocardiography
;
Erythema
;
Ethylenediamines
;
Fever
;
Heart Block
;
Hospitalization
;
Humans
;
Mitral Valve Insufficiency
;
Myocarditis
;
Penicillin G Benzathine
;
Penicillins
;
Rheumatic Fever
;
Streptococcal Infections
2.The Moderating Effect of Social Support on the Relationship between Emotional Labor and Nursing Performance in General Hospital
Hee Sug PARK ; Yang Gyeong YOO
Journal of Korean Academy of Nursing Administration 2019;25(2):136-145
PURPOSE: The present study was conducted to determine the influence of social support on the relationship between emotional labor and nursing performance of general hospital nurses. METHODS: Data collection was conducted at three general hospitals in Jeollabuk-do from August 10 to 25, 2017. Collected questionnaires (188 nurses) were analyzed based on percentages, means, SD, t-test, ANOVA, Scheffé, Pearson correlation analysis, and moderated regression analysis using SPSS Statistics 24.0 software. RESULTS: Social support was found to moderate the influence of nurses' emotional labor on nursing performance. That is, high level of social support can reduce the negative effect of emotional labor on nursing performance. CONCLUSION: Based on findings in the present study, it can be said that establishing positive organizational culture through harmonious social support at the work site is necessary to improve nursing performance. In addition, measures to effectively improve social support need to be explored and practiced at the work site. Efforts should be made to come up with strategies to properly cope with and overcome emotional labor. The results of this study suggest the scope for further research to identify additional variables that moderate or mediate the relationship between emotional labor and nursing performance.
Data Collection
;
Hospitals, General
;
Jeollabuk-do
;
Nursing
;
Organizational Culture
;
Workplace
3.Kawasaki Disease Complicated with Giant Coronary Aneurysm in Case of Systematized Epidermal Nevus
Soonchunhyang Medical Science 2023;29(2):83-86
Kawasaki disease (KD) is an acute systemic vasculitis that involves coronary arteries. Systematized epidermal nevus is a skin disease characterized by extensive verrucous and hyperchromic plaques. A male patient, previously diagnosed with systematized epidermal nevus, was referred for high fever. Eye injection, red lip, strawberry tongue, and enlarged neck node were accompanied. Intravenous immunoglobulin (IVGG) and high-dose aspirin were given for the treatment of KD. An echocardiogram revealed a small aneurysm in the right coronary artery (RCA). Second IVGG was administered because of refractoriness. The size of the aneurysm was increased to medium in RCA and another medium-sized aneurysm was found in the left anterior descending artery (LAD). Clopidogrel was added. After 3 days of defervescence, he was discharged. Warfarin was added for a giant aneurysm in LAD, aggravated 8 weeks later after the presentation. 11 months later, giant aneurysm was changed to medium sized aneurysm. Patient is at following with dual antiplatelet therapy without warfarin.
4.Effects of Perceived Social Support on Self Esteem in Elderly.
Yang Gyeong YOO ; Sung Hee KO ; Kwuy Bun KIM ; Seung Hee CHUNG
Journal of Korean Academy of Adult Nursing 2004;16(1):102-110
PURPOSE: This study was done to identify the degree that perceived social support effects the self esteem of the elderly. METHOD: A structured questionnaire was administered to 203 elderly subjects from April 2003 to June 2003. The data were analyzed with an SPSS program for descriptive statistics, Pearson`s correlation coefficients, t-test, ANOVA, and stepwise multiple regression. RESULTS: The level of social support was moderate; family support received the highest score among sources of support. In types of support, appraisal support was the highest score and material was the lowest. The level of self esteem was also moderate. The score of social support showed a slightly high positive correlation with self esteem. In general characteristics, several variables were significantly related to self esteem. The most powerful predictor of self esteem was material support by family and the variance explained was 19.6%. A combination of material support by family, informational support by relatives, perceived economic status, perceived health status, and having a subject to depend on accounted for 39.8% of the variance in self esteem of the elderly. CONCLUSION: To increase the self esteem of the elderly, it is necessary to consolidate material support by family.
Aged*
;
Humans
;
Self Concept*
;
Surveys and Questionnaires
5.Effects of Perceived Social Support on Self Esteem in Elderly.
Yang Gyeong YOO ; Sung Hee KO ; Kwuy Bun KIM ; Seung Hee CHUNG
Journal of Korean Academy of Adult Nursing 2004;16(1):102-110
PURPOSE: This study was done to identify the degree that perceived social support effects the self esteem of the elderly. METHOD: A structured questionnaire was administered to 203 elderly subjects from April 2003 to June 2003. The data were analyzed with an SPSS program for descriptive statistics, Pearson`s correlation coefficients, t-test, ANOVA, and stepwise multiple regression. RESULTS: The level of social support was moderate; family support received the highest score among sources of support. In types of support, appraisal support was the highest score and material was the lowest. The level of self esteem was also moderate. The score of social support showed a slightly high positive correlation with self esteem. In general characteristics, several variables were significantly related to self esteem. The most powerful predictor of self esteem was material support by family and the variance explained was 19.6%. A combination of material support by family, informational support by relatives, perceived economic status, perceived health status, and having a subject to depend on accounted for 39.8% of the variance in self esteem of the elderly. CONCLUSION: To increase the self esteem of the elderly, it is necessary to consolidate material support by family.
Aged*
;
Humans
;
Self Concept*
;
Surveys and Questionnaires
6.Clinical outcome of acute myocarditis in children according to treatment modalities.
Hyun Jung KIM ; Gyeong Hee YOO ; Hong Ryang KIL
Korean Journal of Pediatrics 2010;53(7):745-752
PURPOSE: There is currently little evidence to support intravenous immune globulin (IVIG) therapy for pediatric myocarditis. The purpose of our retrospective study was to assess the effects of IVIG therapy in patients with presumed myocarditis on survival and recovery of ventricular function and to determine the factors associated with its poor outcome. METHODS: We reviewed all consecutive cases of patients with myocarditis with left ventricular dysfunction verified by echocardiogram who had visited 3 university hospitals between January 2000 and September 2009. These patients were divided into 2 groups. Group 1 consisted of 23 patients (69.6%) who received IVIG alone or IVIG in combination with steroids, and group 2 consisted of 10 patients (30.3%) who received neither IVIG nor other immunosuppressive agents. Clinical manifestations, laboratory results, echocardiographic findings, and outcomes were compared between these 2 groups. RESULTS: One year after the initial presentation, the difference in the probability of survival did not show statistical significance in IVIG-treated patients (P=0.607). Of the echocardiographic parameters on admission, a shortening fraction of less than 15% was associated with unremitting cardiac failure. Furthermore, anemic patients were more likely to have elevated N-terminal fragment levels of the B-type natriuretic peptide (NT-proBNP) in the progressed group (P=0.036). CONCLUSION: There was no difference between the IVIG-treated patients and the control patients in the degree of recovery of left ventricular function and survival. Prospective, randomized, clinical studies are needed to elucidate the effects of IVIG treatment during the acute stage of myocarditis on ultimate outcomes.
Child
;
Heart Failure
;
Hospitals, University
;
Humans
;
Immunoglobulins, Intravenous
;
Immunosuppressive Agents
;
Myocarditis
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Natriuretic Peptide, Brain
;
Retrospective Studies
;
Steroids
;
Ventricular Dysfunction, Left
;
Ventricular Function
;
Ventricular Function, Left
7.Left Ventricular Noncompaction Complicated with Myocardial Infarction with Barth Syndrome in a Newborn.
Soonchunhyang Medical Science 2016;22(1):38-41
Left ventricular noncompaction (LVNC) is a rare cardiomyopathy characterized by a hypertrabeculation of the left ventricle. Patients may present with heart failure, arrhythmia, and thromboembolism. LVNC may be isolated or associated with congenital heart defects. The first discovered genetic cause of isolated LVNC was Barth syndrome (BTHS), an X-linked disorder caused by taffazin (TAZ) gene mutation. BTHS is characterized by cardiomyopathy, neutropenia, skeletal myopathy, and growth delay. A newborn male baby was referred to Soonchunhyang University Cheonan Hospital due to cyanosis and dyspnea. Based on findings of cardiomegaly, ST depression, and elevated cardiac enzyme, echocardiography was done, which revealed a hypocontractile, enlarged left ventricle with distinctive trabeculation in the apex. Heparinization for the treatment of myocardial infarction and continuous infusion of milrinone was started. During hospitalization, the TAZ gene mutation was detected in the patient, his mother, and elder sister. After 3 months, the patient was discharged with heart failure medication and aspirin.
Arrhythmias, Cardiac
;
Aspirin
;
Barth Syndrome*
;
Cardiomegaly
;
Cardiomyopathies
;
Chungcheongnam-do
;
Cyanosis
;
Depression
;
Dyspnea
;
Echocardiography
;
Heart Defects, Congenital
;
Heart Failure
;
Heart Ventricles
;
Heparin
;
Hospitalization
;
Humans
;
Infant, Newborn*
;
Isolated Noncompaction of the Ventricular Myocardium
;
Male
;
Milrinone
;
Mothers
;
Muscular Diseases
;
Myocardial Infarction*
;
Neutropenia
;
Siblings
;
Thromboembolism
8.A Study of the Association between Enabled Homolog Gene Polymorphisms and Kawasaki Disease in Korean Children.
Soonchunhyang Medical Science 2016;22(1):8-15
OBJECTIVE: The etiology of the Kawasaki disease (KD) remains unknown despite of extensive studies but infection, immunity, and genetics were suggested as causes. There have been attempted to link susceptibility to KD to allelic variations to search related gene. The enabled homolog (Enah) gene on the human chromosome 1q42.12 encodes enabled/vasodilator-stimulated phosphoprotein (Ena/VASP). Ena/VASP is a regulator of actin cytoskeleton, exists in cytoplasm, and maintains homeostasis such as immune response, blood vessel preservation, and hemostasis. The aim of this study was to investigate polymorphisms of the Enah gene as a risk factor for KD and coronary artery lesions (CALs) as a complication. METHODS: In the Enah gene region, 15 single nucleotide polymorphisms (SNPs) were selected using human SNP websites (http://www.hapmap.org/, genome build). Three hundred and six healthy controls and 106 KD subjects were recruited. SNP genotyping was performed using the Golden Gate assay on an Illumina BeadStation 500 GX (Illumina Inc., San Diego, CA, USA). Frequencies of allele were obtained and the genetic association between of the Enah gene polymorphisms and susceptibility to KD and CALs was analyzed by SNPstats, Haploview software ver. 4.1 (Broad Institute, Cambridge, MA, USA). Multiple logistic regression analysis with adjustment for gender was performed. RESULTS: One SNP (rs1891000) among total fifteen SNPs was associated with KD. Moreover, we found a significant association between rs487591, rs576861, rs7555139, rs10799319, and the development of CALs in KD patients. CONCLUSION: These results suggest that the polymorphism of Enah gene may be associated with the occurrence of KD and development of CALs as a complication.
Actin Cytoskeleton
;
Alleles
;
Blood Vessels
;
Child*
;
Chromosomes, Human
;
Coronary Vessels
;
Cytoplasm
;
Genetics
;
Genome
;
Hemostasis
;
Homeostasis
;
Humans
;
Logistic Models
;
Mucocutaneous Lymph Node Syndrome*
;
Polymorphism, Single Nucleotide
;
Risk Factors
9.Comparative Study between High Dose Aspirin and Ibuprofen in the Treatment of Kawasaki Disease in the Acute Stage.
Soonchunhyang Medical Science 2018;24(2):175-180
OBJECTIVE: Reye's syndrome can be caused by high dose of aspirin which is for treatment of acute phase of Kawasaki disease. We evaluated the effectiveness of treatment and coronary complications of replacing high dose of aspirin with ibuprofen for children in acute phase of Kawasaki disease. METHODS: Children with Kawasaki disease (n=235) were admitted in the pediatric department from January 1, 2015 to December 31, 2017. Echocardiography and laboratory tests were performed during admission, and the children were followed-up at 6–8 weeks after the onset. We retrospectively analyzed their characteristics and clinical outcomes. RESULTS: The children were assigned to receive either high dose of aspirin with intravenous immunoglobulin (IVIG) (aspirin group) or ibuprofen with IVIG (ibuprofen group). A total of 119 and 116 children were included in the aspirin and ibuprofen groups. Total fever duration was 6.5±1.6 days in the aspirin group, and 6.5±1.7 days in the ibuprofen group (P=0.674). The number of resistance to initial treatments was 11 in the aspirin group and 11 in the ibuprofen group (P=0.571). There were 13 initial coronary complications in the aspirin group, and 10 in the ibuprofen group (P=0.552) and children who showed coronary artery abnormalities improvement at 6- to 8-week follow-up was seven and five in the aspirin and ibuprofen groups, respectively (P=0.769). CONCLUSION: We may consider using ibuprofen in acute phase of Kawasaki disease to prevent the severe complications of aspirin use, such as Reye's syndrome in the case concerning influenza or varicella.
Aspirin*
;
Chickenpox
;
Child
;
Coronary Vessels
;
Echocardiography
;
Fever
;
Follow-Up Studies
;
Humans
;
Ibuprofen*
;
Immunoglobulins
;
Immunoglobulins, Intravenous
;
Influenza, Human
;
Mucocutaneous Lymph Node Syndrome*
;
Retrospective Studies
;
Reye Syndrome
10.Ethyl Acetate Fraction from Cudrania Tricuspidata Inhibits IL-1beta-Stimulated Osteoclast Differentiation through Downregulation of MAPKs, c-Fos and NFATc1.
Eun Gyeong LEE ; Hee Jin YUN ; Sang Il LEE ; Wan Hee YOO
The Korean Journal of Internal Medicine 2010;25(1):93-100
BACKGROUND/AIMS: The present study was performed to determine the effects of the ethyl acetate extract of Cudrania tricuspidata (EACT) on interleukin (IL)-1beta-stimulated receptor activator of NF-kappaB ligand (RANKL)-mediated osteoclast differentiation. METHODS: Bone marrow cells were harvested from 6-week-old male imprinting control region mice, and the differentiation of osteoclasts from these cells was evaluated by tartrate-resistant acid phosphatase and resorption pit formation assay. Phosphorylated extracellular signal regulated kinase (p-ERK), phosphorylated p38, phosphorylated c-Jun amino-terminal kinase, NF-kappaB (p65), IkappaBalpha, c-Fos, and nuclear factor of activated T-cells c1 (NFATc1) expression was examined by immunoblotting and quantitative reverse transcription-polymerase chain reaction. RESULTS: EACT inhibits IL-1beta-stimulated RANKL-mediated osteoclast differentiation. EACT also inhibits IL-1beta-stimulated RANKL-mediated phosphorylation of ERK 1/2, p38 mitogen activated protein kinase, and expression of c-Fos and NFATc1. CONCLUSIONS: These results suggest that EACT may be involved in the inhibition of bone loss by preventing osteoclast formation and may be used to manage bone destruction in inflammatory diseases, such as rheumatoid arthritis.
*Acetates
;
Animals
;
Bone Marrow Cells/cytology/drug effects/metabolism
;
Cell Differentiation/drug effects/physiology
;
Cell Survival/drug effects/physiology
;
Cells, Cultured
;
Down-Regulation/drug effects
;
Extracellular Signal-Regulated MAP Kinases/metabolism
;
Interleukin-1beta/*pharmacology
;
MAP Kinase Signaling System/*drug effects/physiology
;
Male
;
Mice
;
Mice, Inbred ICR
;
*Moraceae
;
NFATC Transcription Factors/metabolism
;
*Osteoclasts/cytology/drug effects/metabolism
;
Plant Extracts/*pharmacology
;
Proto-Oncogene Proteins c-fos/metabolism
;
RANK Ligand/metabolism
;
Stem Cells/cytology/drug effects/metabolism
;
p38 Mitogen-Activated Protein Kinases/metabolism