1.Two Childhood Cases of Heat Stroke with Rhabdomyolysis and Multiorgan Failure.
Yang Suk JUNG ; Jae Young LIM ; Yun Kyeong CHO ; Gye Woo YI ; Chan Hoo PARK ; Hyang Ok WOO ; Hee Shang YOUN
Journal of the Korean Pediatric Society 1998;41(4):568-573
Heat stroke occurs when body thermal regulation is upset and unable to dissipate adequate amounts of heat with rise in body temperature. Thus heat stroke may result in rhabdomyolysis and multiorgan failure. We observed two childhood cases of heat stroke with rhabdomyolysis and multiorgan failure. One case was caused by accidentally being left in a car trunk for 3 hours on a sunny afternoon in late spring and the other case occurred climbing a mountain on a hot summer day during a school trip for improving individual self-control. The first case, a boy almost 5 years old, displayed thetypical clinical features of heat stroke including hyperpyrexia, CNS disturbance, hot dry skin, acute liver failure, rhabdomyolysis, oligo- anuric acute renal failure, and disseminated intravascular coagulopathy. He was treated with general supportive care and daily hemodialysis. Despite the aggressive management, he died of shock on the sixteenth day of admission day. The second case, a 14-year-old middle school boy, displayed similiar features of the first case but showed milder symptoms. He was also treated with general supportive care and daily hemodialysis for 10 days. He recovered completely and was discharged in good condition. The public including medical and paramedical personnels should be warned of the dangers of childhood heat stroke, which is potentially lethal, but preventable.
Acute Kidney Injury
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Adolescent
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Allied Health Personnel
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Body Temperature
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Child
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Child, Preschool
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Heat Stroke*
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Hot Temperature*
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Humans
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Liver Failure, Acute
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Male
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Renal Dialysis
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Rhabdomyolysis*
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Shock
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Skin
2.An outbreak of fatal hemorrhagic pneumonia caused by Streptococcus equi subsp. zooepidemicus in shelter dogs.
Jae Won BYUN ; Soon Seek YOON ; Gye Hyeong WOO ; Byeong Yeal JUNG ; Yi Seok JOO
Journal of Veterinary Science 2009;10(3):269-271
An outbreak of fatal hemorrhagic pneumonia with 70~90% morbidity and 50% mortality occurred in an animal shelter in Yangju, Gyeonggi Province, Korea. Clinically, the affected dogs showed severe respiratory distress within 48 h after arriving in the shelter. The dead were found mainly with nasal bleeding and hematemesis. At necropsy, hemothorax and hemorrhagic pneumonia along with severe pulmonary consolidation was observed, though histopathological analysis showed mainly hemorrhagic bronchopneumonia. Lymphoid depletion was inconsistently seen in the spleen, tonsil and bronchial lymph node. Gram-positive colonies were shown in blood vessels or parenchyma of cerebrum, lung, liver, spleen, and kidney. Also, Streptococcus (S.) equi subsp. zooepidemicus was isolated from the various organs in which the bacterium was microscopically and histologically detected. In addition, approximately 0.9 Kb specific amplicon, antiphagocytic factor H binding protein, was amplified in the bacterial isolates. In this study, we reported an outbreak of canine hemorrhagic bronchopneumonia caused by S. equi subsp. zooepidemicus in an animal shelter in Yangju, Korea.
Animals
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Disease Outbreaks/*veterinary
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Dog Diseases/*epidemiology/*microbiology/pathology
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Dogs
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Korea/epidemiology
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Pneumonia, Bacterial/epidemiology/microbiology/pathology/*veterinary
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Streptococcus equi/isolation & purification/*physiology
3.Identification of urinary microRNA biomarkers for in vivo gentamicininduced nephrotoxicity models
Byung-Suk JEON ; Soo-ho LEE ; So-Ryeon HWANG ; Hee YI ; Ji-Hyun BANG ; Nga Thi Thu THAM ; Hyun-Kyoung LEE ; Gye-Hyeong WOO ; Hwan-Goo KANG ; Hyun-Ok KU
Journal of Veterinary Science 2020;21(6):e81-
Background:
Although previous in vivo studies explored urinary microRNA (miRNA), there is no agreement on nephrotoxicity-specific miRNA biomarkers.
Objectives:
In this study, we assessed whether urinary miRNAs could be employed as biomarkers for nephrotoxicity.
Methods:
For this, literature-based candidate miRNAs were identified by reviewing the previous studies. Female Sprague-Dawley rats received subcutaneous injections of a single dose or repeated doses (3 consecutive days) of gentamicin (GEN; 137 or 412 mg/kg). The expression of miRNAs was analyzed by real-time reverse transcription-polymerase chain reaction in 16 h pooled urine from GEN-treated rats.
Results:
GEN-induced acute kidney injury was confirmed by the presence of tubular necrosis.We identified let-7g-5p, miR-21-3p, 26b-3p, 192-5p, and 378a-3p significantly upregulated in the urine of GEN-treated rats with the appearance of the necrosis in proximal tubules.Specifically, miR-26-3p, 192-5p, and 378a-3p with highly expressed levels in urine of rats with GEN-induced acute tubular injury were considered to have sensitivities comparable to clinical biomarkers, such as blood urea nitrogen, serum creatinine, and urinary kidney injury molecule protein.
Conclusions
These results indicated the potential involvement of urinary miRNAs in chemical-induced nephrotoxicity, suggesting that certain miRNAs could serve as biomarkers for acute nephrotoxicity.
4.Acetylcholinesterase activity in the brain of wild birds in Korea—2014 to 2016
Ji Hyun BANG ; Hyun Ok KU ; Hwan goo KANG ; Hyobi KIM ; Soohee KIM ; Sung Won PARK ; Yong Sang KIM ; Il JANG ; Yu Chan BAE ; Gye Hyeong WOO ; Hee YI
Journal of Veterinary Science 2019;20(2):e9-
Acetylcholinesterase (AChE) activity level can be used as a diagnostic marker for anticholinesterase pesticide poisoning. In this study, we aimed to establish a baseline level of normal brain AChE activity in wild birds. AChE activity was measured in the brains of 87dead wild birds (26 species). The level of AChE activity ranged from 6.40 to 15.9 µmol/min/g of brain tissue in normal wild birds. However, the brain tissue AChE activity level in wild birds exposed to organophosphate (OP) pesticide was 48.0%–96.3% of that in the normal birds. These results may serve as reference values to facilitate routine diagnosis and monitoring of OP-poisoned wild birds.
Acetylcholinesterase
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Birds
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Brain
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Diagnosis
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Organophosphates
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Poisoning
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Reference Values