Four thoroughbred horses showing lameness, ataxia, circling, depression, recumbency, and seizures, were examined. The horses had gross, pale- to dark-red manifestations and foci in the central nervous system (CNS). Multifocal to coalescing eosinophilic necrotizing encephalomyelitis was observed histologically in the CNS along with intact or degenerated nematodes. Nematodes had polymyarian-coelomyarian musculature, a smooth thin cuticle, and intestines lined by multinucleated cells with microvilli. These traits suggested the nematodes belonged to the family Protostrongylidae, which includes Parelaphostrongylus tenuis. It was concluded that the horses were infected by nematodes, presumably Parelaphostrongylus tenuis, resulting in eosinophilic necrotizing encephalomyelitis.
Ataxia ; Central Nervous System ; Depression ; Encephalomyelitis* ; Eosinophils* ; Horses* ; Humans ; Intestines ; Microvilli ; Parasites* ; Seizures

A dead dove was found on the road and submitted for diagnosis. The bird was severely emaciated, with deformation in its facial area. Grossly, white coalescing nodules were seen on the cut surface of the nasal cavity. Histopathologically, epithelial cells of the upper respiratory tract were markedly proliferated, with ballooning degeneration, down growth of the rete ridge, and large eosinophilic intracytoplasmic inclusion bodies. Parakeratotic hyperkeratosis and focal necrotic focus was present in the proliferative area. The facial bones showed partial bone resorption. Transmission electron microscopy revealed numerous viral particles in epithelial cells with dumbbell-shaped bodies, consistent with poxvirus.
Birds ; Bone Resorption ; Columbidae* ; Diagnosis ; Eosinophils ; Epithelial Cells ; Facial Bones ; Inclusion Bodies ; Microscopy, Electron ; Microscopy, Electron, Transmission ; Nasal Cavity ; Respiratory System ; Turtles* ; Virion

An adult female ringed seal died suddenly and was subsequently examined for diagnostic purposes. The animal's lungs demonstrated mild non-collapsibility and multifocal white to yellow patches. Histopathological examination revealed multifocal pulmonary histiocytosis. Alveoli were filled with numerous foamy macrophages cytoplasm and scattered multinucleated giant cells containing cholesterol clefts. The foamy cytoplasm of the macrophages stained with oil red O stain. Further, lipid droplets within the cytoplasm were detected by electron microscopy. To the author’s knowledge, this is the first case report describing the histochemical staining and electron microscopic findings associated with endogenous lipid pneumonia in ringed seal.

The degree of facial asymmetry in P -A cephalogram may differ from that we felt in clinical examination. The purpose of this study was to find out the P -A cephalometric measurements affecting the visual facial asymmetry. Fifty four adult patients who had been diagnosed as the facial asymmetry in clinical examination were selected for this study. Through the analysis of facial photograph and P -A cephalogram, the following results were obtained: 1. In linear measurements, Me (Menton) to MSR (Mid -sagittal reference line), Cd (Condylion) to Me, Ag (Antegonion) to Me, and Ag to MSR were significantly related with facial asymmetric index. 2. In angular measurements, angle Cg -Me plane to MSR, angle ANS -Me plane to MSR, and angle Cd - Ag -Me were significantly related with facial asymmetric index. Especially, angle Cg -Me plane to MSR, angle ANS -Me plane to MSR were highly related. 3. In surface measurements, Cg -Ag -Ag ' and Cd -Ag -Me -Cd ' were significantly related with facial asymmetric index. The results of this study suggested that menton point was the most affected landmark in visual facial asymmetry.
Adult ; Facial Asymmetry* ; Humans

This study was performed to compare the attractiveness of facial profile among the patients, parents and orthodontists. Six untreated patients between the ages 15 ~25 with Angle 's Class I, Class II, Class III malocclusion were chosen from the Chonnam National University hospital orthodontic department. The images were altered with of the computer to simulate varying degrees of mandibular retrusion and protrusion. The results of this study were obtained as follows: 1. No significant differences in attractiveness of facial profile among the patients, parents and orthodontists. 2. More protrusive lip position was preferred in female than male. 3. More protrusive chin was preferred in orthodontist group than patients, and parents, but there were no significant differences.
Chin ; Female ; Humans ; Jeollanam-do ; Lip ; Male ; Malocclusion ; Parents ; Retrognathia

The purpose of this study was to examine the cytotoxicity of orthodontic wire which had an increased diameter through electroplating, and to evaluate its possible clinical applications. First, nickel plating was carried out on the commercially available stainless steel wire using an electroplating technique. For the comparison of the electroplated wire with ready made stainless steel wire and titanium or copper, each wire was incubated for 72 hours in a medium. The release of the metal ion was measured using ICP-AES (Inductively Coupled Plasma Atomic Emission Spectrophotometer). Balb/c 3T3 mouse fibroblast was put on a microplate and placed in an incubated medium of 75%, 50%, and 20% dilation. An MTT analysis was used to compare with the medium only. The change in absorbency value of each wire group and the difference of absorbency value according to the change of dilution was measured. The results of ICP-AES analysis showed that great amount nickel ion was isolated from electroplated orthodontic wires and great amount copper ion was isolated from copper. The results of the MTT analysis showed that there was no difference in the absorbency value of titanium at any dilution. However, the electroplated wires (p < 0.001), the stainless steel wires (p < 0.05) and the copper (p < 0.001) were statistically significantly lower than those of medium only at all dilutions. Assessment as per ISO 10993, part 5, showed that electroplated wire was alloted to "moderate cytotoxic", the titanium and stainless steel wire were "non-cytotoxic". The results of this study indicate that the electroplated orthodontic wires need additional efforts to decrease cytotoxicity for their clinical applications.
Animals ; Copper ; Electroplating ; Fibroblasts ; Mice ; Nickel ; Orthodontic Wires* ; Plasma ; Stainless Steel* ; Titanium

The purpose of this study was to compare and evaluate the upper airway structure between the snorers and asymptomatic control subjects depending on the positional change. Lateral cephalograms in the upright and supine position were taken in 25 female snorers and 20 female asymptomatic control subjects, The length and the area of the soft palate, tongue and airway were measured and evaluated statistically. The results obtained were as follows : 1. The snorers showed longer and higher tongue, narrower and longer airway, inferiorly positioned hyoid bone, longer and broader soft palate and narrower hypopharynx than the control subjects both in the upright and supine position. In addition, the snorers showed broader tongue area and narrower oropharynx area than the control subjects in supine position. 2. Depending on the positional change from upright to supine position, the controls and the snorers showed decreased airway length and superior positioned the hyoid bone. In addition, the snorers showed decreased tongue length and height, airway length and thickness and oropharynx area, but increased tongue area and soft palate area.
Female ; Humans ; Hyoid Bone ; Hypopharynx ; Oropharynx ; Palate, Soft ; Supine Position* ; Tongue

BACKGROUND: Antimicrobial susceptibility testing (AST) of Clostridium difficile is increasingly important because of the rise in resistant strains. The standard medium for the AST of C. difficile is supplemented Brucella agar (sBA), but we found that the growth of C. difficile on sBA was not optimal. Because active growth is critical for reliable AST, we developed a new, modified C. difficile (mCD) agar. C. difficile grew better on mCD agar than on sBA. METHODS: C. difficile isolates were collected from patients with healthcare-associated diarrhea. sBA medium was prepared according to the CLSI guidelines. Homemade mCD agar containing taurocholate, L-cysteine hydrochloride, and 7% horse blood was used. For 171 C. difficile isolates, we compared the agar dilution AST results from mCD agar with those from sBA. RESULTS: No significant differences were observed in the 50% minimal inhibitory concentration (MIC50) and 90% minimal inhibitory concentration (MIC90) of clindamycin (CLI), metronidazole (MTZ), moxifloxacin (MXF), piperacillin-tazobactam (PTZ), and rifaximin (RIX), but the values for vancomycin (VAN) were two-fold higher on mCD agar than on sBA. The MICs of CLI, MXF, and RIX were in 100% agreement within two-fold dilutions, but for MTZ, VAN, and PTZ, 13.7%, 0.6%, and 3.1% of the isolates, respectively, were outside the acceptable range. CONCLUSIONS: The MIC ranges, MIC50 and MIC90, were acceptable when AST was performed on mCD agar. Thus, mCD agar could be used as a substitute medium for the AST of C. difficile.
Anti-Infective Agents/*pharmacology ; Clostridium Infections/microbiology ; Clostridium difficile/*drug effects/isolation & purification ; Diarrhea/*microbiology ; Humans ; Microbial Sensitivity Tests/*methods

With the advances of digital scanning technology in dentistry, the interests in facial scanning in orthodontics have increased.There are many different manufacturers of facial scanners marketing to the dental practice. How do you know which one will work best for you? What questions should you be asking? We suggest a clinical guideline which may help you make an informed decision when choosing facial scanners. The characteristics of 7 facial scanners were discussed in this article. Here are some considerations for choosing a facial scanner. *Accuracy: For facial scanners to be of real value, having an appropriate camera resolution is necessary to achieve more accurate facial image representation. For orthodontic application, the scanner must create an accurate representation of an entire face. *Ease of Use: Scanner-related issues that impact their ease of use include type of light; scan type; scan time; file type generated by the scanner; unit size and foot print; and acceptance of scans by third-party providers. *Cost: Most of the expenses associated with facial scanning involve the fixed cost of purchase and maintenance. Other expenses include technical support, warranty costs, transmission fees, and supply costs. This article suggests a clinical guideline to make the right choice for facial scanner in orthodontics.

Eosinophilic granuloma is a common hypersensitive inflammatory skin disease in cats, and rare in dogs and horses. The skin biopsies of 5 years old female Cocker spaniel and 2 years old female mixed dog had the clinical signs of skin nodules with alopecia were submitted for diagnosis. Solitary skin nodules and papillary nodules were presented on the left external ear and back of Cocker spaniel and on the external ear of mixed dog, respectively. Histopathologically, epidermis of skin showed mild to severe hyperplasia with multifocal ulceration. Small to large irregular, brightly eosinophilic foci with degenerating eosinophils and homogeneous degenerated collagens were existed in the dermis of both ear and back skin. Typical 'flame figures', a mixture of degenerated collagen and degranulated eosinophils, were observed in both cases. Based on the histopathologic findings and special staining characters, 2 cases were diagnosed as canine eosinophilic granuloma. This is the first report for the eosinophilic granuloma of dogs in Korea.
Alopecia ; Animals ; Biopsy ; Cats ; Collagen ; Dermis ; Dogs ; Ear ; Ear, External ; Eosinophilic Granuloma ; Eosinophils ; Epidermis ; Female ; Horses ; Humans ; Hyperplasia ; Korea ; Skin ; Skin Diseases ; Ulcer