PURPOSE: To provide the morphometric data about the Korean proximal tibia to design a total knee prosthesis for Korean population. MATERIALS AND METHODS: We measured morphologic data from the proximal part of the tibia from 60 knees of 30 male and 30 female cadavers. The 3D images were reconstructed from the data obtained by computed tomography scanning from femoral head to ankle joint. These image were processed as a ideal tibial resection surface which was made during a total knee arthroplasty operation. Then, antero-posterior lengths, medio-lateral lengths and aspect ratios of the cut surface were measured. Measurements were analyzed and compared with those of five popular total knee prosthesis models. RESULTS: The average medio-lateral length, lateral antero-posterior length, aspect ratio of male was 79.4 +/- 3.8 mm, 39.6 +/- 5.0 mm, 49.8 +/- 5.1% respectively. And that of female was 70.4 +/- 3.7 mm, 34.3 +/- 3.6 mm, 48.8 +/- 4.7% respectively. Component size of medio-lateral length of 65~85 mm and lateral antero-posterior length of 30~45 mm, would be required for the Korean population. Aspect ratios were correlated to antero-posterior lengths positively (p < 0.05). CONCLUSION: No prostheses had fulfilled all the requirements for Korean knees in this study. These data could be used for design the optimal components for Korean.
Ankle Joint ; Arthroplasty* ; Cadaver ; Female ; Head ; Humans ; Knee Prosthesis ; Knee* ; Korea* ; Male ; Prostheses and Implants ; Tibia*

PURPOSE: To provide the morphometric data about the Korean proximal tibia to design a total knee prosthesis for Korean population. MATERIALS AND METHODS: We measured morphologic data from the proximal part of the tibia from 60 knees of 30 male and 30 female cadavers. The 3D images were reconstructed from the data obtained by computed tomography scanning from femoral head to ankle joint. These image were processed as a ideal tibial resection surface which was made during a total knee arthroplasty operation. Then, antero-posterior lengths, medio-lateral lengths and aspect ratios of the cut surface were measured. Measurements were analyzed and compared with those of five popular total knee prosthesis models. RESULTS: The average medio-lateral length, lateral antero-posterior length, aspect ratio of male was 79.4 +/- 3.8 mm, 39.6 +/- 5.0 mm, 49.8 +/- 5.1% respectively. And that of female was 70.4 +/- 3.7 mm, 34.3 +/- 3.6 mm, 48.8 +/- 4.7% respectively. Component size of medio-lateral length of 65~85 mm and lateral antero-posterior length of 30~45 mm, would be required for the Korean population. Aspect ratios were correlated to antero-posterior lengths positively (p < 0.05). CONCLUSION: No prostheses had fulfilled all the requirements for Korean knees in this study. These data could be used for design the optimal components for Korean.
Ankle Joint ; Arthroplasty* ; Cadaver ; Female ; Head ; Humans ; Knee Prosthesis ; Knee* ; Korea* ; Male ; Prostheses and Implants ; Tibia*

Background/Aims: Enzymatic analysis of aspartate/alanine aminotransferase (AST/ALT) does not exactly represent the progression of liver fibrosis or inflammation. Immunoassay for AST (cytoplasmic [c] AST/mitochondrial [m] AST) and ALT (ALT1/ALT2) has been suggested as one alternatives for enzymatic analysis. The objective of this study was to evaluate the efficacy of immunoassay in predicting liver fibrosis and inflammation. Methods: A total of 219 patients with chronic hepatitis B (CHB) who underwent hepatic venous pressure gradient (HVPG) and liver biopsy before antiviral therapy were recruited. Serum samples were prepared from blood during HVPG. Results of biochemical parameters including enzymatic AST/ALT and immunological assays of cAST, mAST, ALT1, and ALT2 through sandwich enzyme-linked immunosorbent assay (ELISA) immunoassay with fluorescence labeled monoclonal antibodies were compared with the results of METAVIR stage of live fibrosis and the Knodell grade of inflammation. Results: METAVIR fibrosis stages were as follows: F0, six (3%); F1, 52 (24%); F2, 88 (40%); F3, 45 (20%); and F4, 28 patients (13%). Mean levels of AST and ALT were 121 ± 157 and 210 ± 279 IU/L, respectively. Mean HVPG score of all patients was 4.7 ± 2.5 mmHg. According to the stage of liver fibrosis, HVPG score (p < 0.001, r = 0.439) and ALT1 level (p < 0.001, r = 0.283) were significantly increased in all samples from patients with CHB. ALT (p < 0.001, r = 0.310), ALT1 (p < 0.001, r = 0.369), and AST (p < 0.001, r = 0.374) levels were positively correlated with Knodell grade of inflammation. Conclusions ALT1 measurement by utilizing sandwich ELISA immunoassay can be useful method for predicting inf lammation grade and fibrosis stage in patients with CHB.

Background: Pediatric alopecia areata (AA) can affect the quality of life (QoL) of patients and their family members. Research on the QoL and burden on family members in pediatric AA is limited. Objective: This nationwide multicenter questionnaire study described the QoL and burden of the family members of patients with pediatric AA. Methods: This nationwide multicenter questionnaire study enrolled AA patients between the ages of 5 and 18 years from March 1, 2017 to February 28, 2018. Enrolled patients and their parents completed the modified Children’s Dermatology Life Quality Index (CDLQI) and the modified Dermatitis Family Impact (mDFI). The disease severity was measured using the Severity of Alopecia Tool (SALT) survey scores. Results: A total of 268 patients with AA from 22 hospitals participated in this study. Our study found that the efficacy and satisfaction of previous treatments of AA decreased as the severity of the disease increased. The use of home-based therapies and traditional medicines increased with the increasing severity of the disease, but the efficacy felt by patients was limited. CDLQI and mDFI scores were higher in patients with extensive AA than those with mild to moderate AA. The economic and time burden of the family members also increased as the severity of the disease increased. Conclusion The severity of the AA is indirectly proportional to the QoL of patients and their family members and directly proportional to the burden. Physicians need to understand these characteristics of pediatric AA and provide appropriate intervention to patients and their family members.

PURPOSE: To evaluate the incidence and clinical features of age-related macular degeneration (AMD) in Korea. METHODS: Web-based (www.armd-nova.or.kr) registration was conducted for AMD patients aged 50 or more who were newly diagnosed by retinal specialists in Korea from August 20, 2005 to August 20, 2006. Patient data including ophthalmologic examination, fundus photography, fluorescein angiogram and/or indocyanin green angiogram (ICG), past medical history, behavioral habit, combined systemic diseases were up-loaded. RESULTS: Among finally enrolled 1,141 newly diagnosed AMD patients, 690 patients (60.5%) were male and 451 patients (39.5%) were female. The average age of AMD patients was 69.7+/-8.0. Early AMD was observed in 190 patients and 951 patients had late AMD. Classic choroidal neovascular membrane (CNVM) was observed in 18.6% of exudative AMD patients and 63.4 % had occult CNVM. Subfoveal CNVM was observed in 80.4% of the patients with CNVM. Among the 580 exudative AMD eyes that performed indocyanin green angiography (ICG), 184 eyes (31.7%) had polypoidal choroidal vasculopathy (PCV) and 36 eyes (6.2%) showed retinal angiomatous proliferation (RAP). Age, male gender, smoking, diabetes and hypertension significantly increased the risk of the AMD among Koreans. CONCLUSIONS: Because of the low rate of participation by retinal specialists, definite incidence of AMD was not obtainable. However, the estimated 1-year AMD incidence in the Pusan area of Korea is at least 0.4%. In contrast to Western people, 31.7% of exudative AMD cases were revealed to be PCV and 6.2% were revealed to be RAP. This discrepancy between ethnic groups should be considered in the diagnosis and treatment modality selection of Korean AMD patients.
Aged ; Angiography ; Choroid ; Ethnic Groups ; Eye ; Female ; Fluorescein ; Humans ; Hypertension ; Incidence ; Korea ; Macular Degeneration ; Male ; Membranes ; Photography ; Retinaldehyde ; Smoke ; Smoking ; Specialization