This study was done to study the effect of UVA radiation upon sunburn cell formation by UVB. In this study a total of 67 ICR male albino haired mice were used. The results were as follows: 1. UVA radiation produce a little or no sunburn cell in doses 5 J/cm(2), 10 J/cm(2), and 15 J/cm(2). 2. Preirradiation of UVA 5 J/cm, 10 J/cm(2), 15 J/cm(2) had no effect on the sunburn cell formation by UVB 20 mJ/cm(2), 80 mj/cm(2)
Animals ; Hair ; Humans ; Male ; Mice ; Sunburn*

We report a case of solar urticaria being activated by both UVA and visible radiation and positive in passive transfer test by visible light, which was treated with sunlight and UVA radiation. A short course of treatment with sunlight produced no benificial effect. UVA phototherpy produced a rnarked increase in the minirnal urtication dose by UVA but there was no increased tolerance to sun exposure.
Intradermal Tests ; Light ; Phototherapy ; Solar System ; Sunlight* ; Urticaria*

No abstract available.
Liver Cirrhosis* ; Liver*

BACKGROUND: Metallothioneins(MTs) are ubiquitous low molecular weight cytosolic proteins with high contents of cystein that xhibit a selective binding affinity for zinc, copper and other group II heavy metal ions. In additi~on to the sequestration function and detoxification action, MTs probably participate in the cellirlar protection against. ionizing radiation and alkylating agent cytotoxicity and in cellular pn:liferation. OBJECT: The objective of this study was to evaIuate the expression of MTs and to clarify t.heir role in carcinogenesis and/or biological behaviour in the neoplasms of ectoderrnal origin. METHODS: We performed immunohistochemical studies on the surgical specimens of rnalignant rnelanoma and squamous cell carcinoma and basal cell carcinoma. The results were compared with the normal skin and mu osa and hair t,issues and raf't-on culture tissues of skin and mucosal keratinocytes. RESULTS: 1) MTs were strongly expressed in epidermal basal cells of the normal skin and raft-on cultured artificial skin They were also rnore weakly expressed in epithelial basal cells of the normal mucosa and raft on cultured artificial mucosa and in matrix cells of the normal hair. 2) In rnalignant melanoma, MTs were meaningfully expressed, i.e., a strong expression was seen in the lesions showing a rapid vertical growth phase with fatal out,comes, but a weak expression in the cases whose precursor lesions were thought as dysplastic nevi, compared to the negative finding of norrnal melanocyt,es. The strong expression in a case of congenit.al rnelanocyt.ic nevus is considered as the activation of nevoid melanocytes. 3) MTs were weakly expressed in squarnous cell carcinoma with a diffuse aattern within the tumor mass. St,rong expression of MTs was particularly apparent in the poorl. differentiated squamous cell carcinoma and at the growing border of well differentiated squamous cell carcinoma. 4) In basal cell carcinoma, MTs were rather weakly expressed in solid cireumscribed types with a diffuse pattern and in cystic type with a patchy pattern. However they were not expressed in the solid infiltrative type. CONCLUSION: From these resuilts, we concluded that MTs were ubiquitously present in possible stem cells of various epithelial tissues except melanocytes irrespective of normal or artificial skin and/or mucosa including norrnal hair tissues. In the neoplasms of ectodermal origin, MTs might be involved in the invasive growth of tumor cells in the malignant melanoma and squamous cell carcinoma. It was implied that the role of MTs in basal cell carcinoma might be related to early events of hasal cell carcinogeresis and its down regulating tendency could be possible in its infil trative stage.
Carcinogenesis ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Copper ; Cytosol ; Dysplastic Nevus Syndrome ; Ectoderm* ; Hair ; Ions ; Keratinocytes ; Melanocytes ; Melanoma ; Metallothionein* ; Molecular Weight ; Mucous Membrane ; Nevus ; Radiation, Ionizing ; Skin ; Skin, Artificial ; Stem Cells ; Zinc

This study was undertaken to elucidate extracutaneous hyperpigmentation of nevus of Ota by analyzing the 70 patients who visited Cryosurgery Clinic in Seoul National University Hospital between January 1984 and March 1985 This results were as follows: 1. The age of onset showed two peaks: the first one was at birth or soon after birth; 27 cases(38. 6%) and the second une was between 11 and 17 years; 37 cases (45. 7%). 2 Seventy cases were classified by Taninos method: 15.7% was type I a, 27. l% type I b, 28. 6% type Il, 20. O% type g and 8. 6% type IV 3.Fifty two out of 70 cases who were examined at the department of ophtha1rnology: pigrnentation of sclera was observed in 29 cases(55. 8%.), of conjunctiva in 18 cases(34.6%), of uveal tract in 14 cases(26. 9A), of fundus in 14 cases (26. 9%) and of optic papilla in 2 cases(3. 8%). 4 Fifty two out of 70 cases who were examined at the department of Otorhinolaryngology. pigmentation of tympanum was observed in ]0 cases(23, 8%,), of nasal mucosa in 6 cases(14. 3p,), of oral mucosa in 5 cases(11, 9%), of external auditory canal in 4 cases(9 5%) and of pharynx in 1 case(2.4%,)
Age of Onset ; Conjunctiva ; Cryosurgery ; Ear Canal ; Ear, Middle ; Humans ; Hyperpigmentation* ; Mouth Mucosa ; Nasal Mucosa ; Nevus of Ota* ; Nevus* ; Optic Disk ; Otolaryngology ; Parturition ; Pharynx ; Pigmentation ; Sclera ; Seoul ; United Nations

Solar urticaria is an uncommon disorder characterized by rapid development of urticarial reaction in areas of skin exposed to nonizing electromagnetic radiation. Herber and Baer classified solar urticaria into eight types on the basis of action spectrum and passive or reverse passive transfer ability. We report two cases of type ]g solar urticaria which were activated by visible light and negative in both passive and reverse passive transfer test.
Electromagnetic Radiation ; Intradermal Tests ; Light ; Skin ; Transfer (Psychology) ; Urticaria*

Kasabach- Merritt syndrame consists of thrombocytopenia, microangiopathic hemolytic anemia, and an acute or chronic censumptive coagulopathy in associati an with a rapidly enlarging hemangioma. Most vascular turrnrs causing Kasabach-Merritt syndon e are benign but the associated coagulopathy may be lifethreatening. Our patient, a 30-day-old female infant, was admitted after an increase in the size of a hemangioma present since birth on the right leg with extension to the lower abdomen and left inguinal area. Her herrnglobin count fell to 7.1g/dl, platelet count was 26,000/ul, prothrombin time was 26 seconds, and hypofibrinogenemia developed. The patient was treated with transfusions of platelets, fresh frozen plasma and red cells and prednisolone. for 2 weeks without improvement. We started interferon alfa-2a therapy. Over the past 6 months, he hemangioma progressively diminished in size withcut any serious complication.
Abdomen ; Anemia, Hemolytic ; Female ; Hemangioma ; Humans ; Infant* ; Interferon-alpha* ; Interferons* ; Kasabach-Merritt Syndrome ; Leg ; Parturition ; Plasma ; Platelet Count ; Prednisolone ; Prothrombin Time ; Thrombocytopenia

Chronic actinic dermatitis was recently proposed to be a syndrome of chronic photosen-sitivity that incudes photosensitive eczema, persitent light reection, photosensitivity dermatitis and actinic reticuloid. We report herein a case of chronic actinic dermatitis which occured in a 60-year-old man. He suffered from a chronic eczematous dermatitis affecting e posed skin and some covered area with a feature of erythroderma. Phototesting showed abnormal photosensitivity to both UVB and UVA as will as to visible light. Skin biopsy specimes revealed histologic findings of spongiotic dermatitis in which dermal infiltrates were mainy consisted of T lymphocytes with suppressor T cells dominance on immunohistochemistry.
Actins ; Biopsy ; Dermatitis ; Dermatitis, Exfoliative ; Eczema ; Humans ; Immunohistochemistry ; Light ; Middle Aged ; Photosensitivity Disorders* ; Skin ; T-Lymphocytes

Many sensitizing chemicals and additives are used in manifacturing and mending dentures. Among them, phtolyldiethanolamine, a kind of accelerto for polymerization, is necessary only in self-curing acrylic resins which are available for repairing and relining of denture. Although the sotirce of denture stomatitis is still controversial, a true allergy to denture base materials can be recognized by a patch test. We report a case of allergic contact stomatitis due to dentn e relining materials in a 65-year-old denturecariying edentulous patient. Patch testievi.aled positive reaction to polyldiethanolamine which is considerd to be contained in a cold curing acrylic resin fluid.
Acrylic Resins ; Aged ; Denture Bases ; Denture Rebasing* ; Dentures* ; Humans ; Hypersensitivity ; Patch Tests ; Polymerization ; Polymers ; Stomatitis* ; Stomatitis, Denture

We report two familial cases of reticulate acropigmentation of kitamura in 20-year-old male and 29-year-old female patients in which reticualte, brownish, slightly depressed pigmentation developed on acral parts of extremities and subsequently extended proximally. Characteristic pits and breaks on palms and soles were noted. Histologic findings revealed epidermal atrophy and enlongation of rete ridges with large amounts of melanin. Electron microscopic findings showed increased melanogenesis in melanocytes and numerous melanosomes and melanosome complex in keratinocytes.
Adult ; Atrophy ; Extremities ; Female ; Humans ; Keratinocytes ; Male ; Melanins ; Melanocytes ; Melanosomes ; Pigmentation ; Young Adult