1.A Study on the Serum Nickel Concentration During Delivery.
Kee Ho KO ; Jin Hee LEE ; Gwang Wook LEE ; Jin Su CHOI
Korean Journal of Preventive Medicine 1988;21(2):351-356
To evaluate the possible functional role of serum during the process of parturition, 15 serum samples were collected and analyzed for the nickel concentrations in each 3 groups(Group 1 for the period during parturition, Group 2 for the period from delivery of fetus to delivery of placenta, and Group 3 for the period after delivery of placenta) of normal, uncomplicated full term vaginal delivery and one control group composed of healthy unmarried women in 3rd decades of age. Data revealed that average serum nickel concentration of Group 2(26.6 microgram/l) and Group 1(22.2 microgram/l) were significantly higher than that of Control group(13.7 microgram/l), but Group 3's(13.8 microgram/l) was almost same as Control group's. There were significant negative correlation between age and serum nickel concentration in group 2, and a tendency of higher nickel concentration in women who have no previous experiences of pregnancy than who have previous experiences of pregnancy, although it was not significant. These result could be indicative of close causal relationship between serum nickel concentration and the entire process of parturition.
Female
;
Fetus
;
Humans
;
Nickel*
;
Parturition
;
Placenta
;
Pregnancy
;
Single Person
2.Survival and Prognostic Factors in Patients with Small Hepatocellular Carcinoma after Curative Resection.
Gwang Hoon WOO ; Jung Hwan YOON ; Chul Ju HAN ; Hyo Suk LEE ; Kun Wook LEE ; Chung Yong KIM
Korean Journal of Medicine 1997;53(5):686-693
BACKGROUND: The survival in patients with hepatocellular carcinoma (HCC) has recently been improved by the advancement in the early detection of HCC. Among the various treatment modalities, the surgical resection has been considered as the most effective for small HCC, and the clinical course of patients with small HCC who underwent curative resection is known to be dependent on the etiology of HCC. Since the differences in the etiology of HCC depend on the different geographical area, it is necessary to verify the clinical outcomes and their affecting factors in patients with small HCC after curative resection in Korea, one of the hepatitis- B-virus(HBU)-endemic areas. METHODS: A total of 89 patients with small HCC (
Carcinoma, Hepatocellular*
;
Classification
;
Follow-Up Studies
;
Hepatitis B Surface Antigens
;
Humans
;
Korea
;
Liver
;
Liver Cirrhosis
;
Mortality
;
Prognosis
;
Recurrence
;
Retrospective Studies
;
Seoul
;
Survival Rate
3.Intrauterine Growth Curve of Twins on the Basis of Gestational Age.
Suk Young KIM ; Gwang Joon KIM ; Yong Wook KIM ; Jee Sung LEE ; Byung Chul HWANG ; Yoo Duk CHOI
Korean Journal of Obstetrics and Gynecology 2000;43(11):1932-1938
OBJECTIVE: In order to investigate more accurate patterns of intrauterine growth in twin fetuses, we constructed the twin-specific growth curve based on gestational age in live-born non-anomalous infants. METHODS: 563 twin pairs, 1,126 infants delivered between January 1994 and October 1999 were comprised our study population. The newborns were grouped according to gestational age and the median, 10th, 50th, and 90th percentile birth weight for each gestational week were calculated. Curves were plotted for the general population and for each gender and parity and compared with previously reported singleton's growth curve. RESULTS: After 32 weeks gestation, birth weight of twins falls below that of singleton, so that by 38 weeks the 50th percentile for twins falls below the singleton 10th percentile. This difference was also present among all subgroups of twins, such as gender and parity. And the mean birth weight in male twin infant was heavier than in female twin infant throughout all gestational week. CONCLUSION: The pattern of growth in twin infants differed from those of singleton. We recommend twin-specific growth curve for clinical use in the management of twin gestations.
Birth Weight
;
Female
;
Fetus
;
Gestational Age*
;
Humans
;
Infant
;
Infant, Newborn
;
Male
;
Parity
;
Pregnancy
;
Twins*
4.Open Posterior Approach versus Arthroscopic Suture Fixation for Displaced Posterior Cruciate Ligament Avulsion Fractures: Systematic Review
Jae Gwang SONG ; Kyung Wook NHA ; Se Won LEE
The Journal of Korean Knee Society 2018;30(4):275-283
PURPOSE: To compare the clinical outcomes between the open posterior approach and arthroscopic suture fixation for displaced posterior cruciate ligament (PCL) avulsion fractures. METHODS: A literature search was performed on MEDLINE, EMBASE, and the Cochrane Library databases. The inclusion criteria were as follows: papers written in English on displaced PCL avulsion fractures, clinical trial(s) with clear description of surgical technique, adult subjects, a follow-up longer than 12 months and modified Coleman methodology score (CMS) more than 60 points. RESULTS: Twelve studies were included with a mean CMS value of 72.4 (standard deviation, 7.6). Overall, 134 patients underwent the open posterior approach with a minimum 12-month follow-up, and 174 patients underwent arthroscopic suture fixation. At final follow-up, the range of Lysholm score was 85–100 for the open approach and 80–100 for the arthroscopic approach. Patients who were rated as normal or nearly normal in the International Knee Documentation Committee subjective knee assessment were 92%–100% for the open approach and 90%–100% for the arthroscopic approach. The range of side-to-side difference was 0–5 mm for both approaches. CONCLUSIONS: Both arthroscopic and open methods for the treatment of PCL tibial-side avulsion injuries resulted in comparably good clinical outcomes, radiological healing, and stable knees.
Adult
;
Arthroscopy
;
Follow-Up Studies
;
Humans
;
Knee
;
Posterior Cruciate Ligament
;
Sutures
5.Relationship between the Expression of Platelet-Derived Endothelial Cell Growth Factor(PD-ECGF), Basic Fibroblast Growth Factor(bFGF), Vascular Endothelial Growth Factor(VEGF) and Clinical Stage in Squamous Cell Carcinoma of Larynx.
Hyun Soo KIM ; Kyung Wook HEO ; Min Ho LEE ; Sae Gwang PARK ; Jae Wook EOM
Korean Journal of Otolaryngology - Head and Neck Surgery 2002;45(5):488-494
BACKGROUND AND OBJECTIVES: Normal angiogenesis occurs as a part of the body's repair processes like the healing of wounds and fractures. By contrast, uncontrolled angiogenesis can often be pathological. Vascular remodelling could therefore play an important role in the growth process of solid tumors. The aim of this study was to detect the expression of platelet-derived endothelial cell growth factor (PD-ECGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), and investigate the correlation between these factors. Also, we studied the relationships between the expressions of these factors and the clinical stage, nodal involvement, and histologic grade in the squamous cell carcinoma of larynx. MATERIALS AND METHOD: The authors examined the expression of three angiogenic factors in specimens of laryngeal squamous cell carcinoma (n=17). The mRNA expressions of angiogenic factors were detected by the semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). Statistics were analysed using the Fisher's exact test, the Wilcoxon signed rank test, and the Spearman correlation coefficiency. RESULTS: PD-ECGF and bFGF were significantly higher in the stages III and IV cancers than in the stages I and II cancers, and thus shows that bFGF was related to severity of the nodal involvement. The expression of more than one factor was significantly related with stages III and IV cancer. PD-ECGF and VEGF were related with each other. CONCLUSION: The authors suggest that angiogenic factors, especially, PD-ECGF and bFGF, may be used as prognostic factors for the squamous cell carcinoma of larynx.
Angiogenesis Inducing Agents
;
Carcinoma, Squamous Cell*
;
Endothelial Cells*
;
Fibroblast Growth Factor 2
;
Fibroblasts*
;
Larynx*
;
RNA, Messenger
;
Thymidine Phosphorylase
;
Vascular Endothelial Growth Factor A
;
Wounds and Injuries
6.Clinical Efficacy of Beta-hCG at Second Trimester as the Marker to Predict Pregnancy-Induced Hypertension.
Gyung Hoon LEE ; Yong Min CHO ; Chul Gyu KANG ; Young Soo RHO ; Byung Chul CHOI ; Yong Wook KIM ; Jong Min LEE ; Gwang Joon KIM ; Yoo Duk CHOI
Korean Journal of Obstetrics and Gynecology 2000;43(8):1368-1374
No abstract available.
Female
;
Humans
;
Hypertension, Pregnancy-Induced*
;
Pregnancy
;
Pregnancy Trimester, Second*
7.Comparison of Blood Loss between Intra-Articular and Intravenous Tranexamic Acid Following Primary Total Knee Arthroplasty.
Gwang Chul LEE ; Dong Hwi KIM ; Jung Woo LEE ; Sin Wook KANG ; Sung Won CHO
The Journal of the Korean Orthopaedic Association 2018;53(2):152-158
PURPOSE: To investigate the difference in blood loss between two injection methods, intravenous (IV) and intra-articular (IA) methods via drain tube. MATERIALS AND METHODS: A total of 183 patients who underwent total knee arthroplasty between October 2013 and March 2016 were included. The method of tranexamic acid (TXA) administration was intravenously injected before August 2015, and it was applied thereafter to the joint through a drainage tube post intra-articular suture. Our subjects were divided into the following groups: The intravenous unilateral (IVU), intravenous bilateral (IVB), intra-articular unilateral (IAU), and intra-articular bilateral (IAB) groups. Hemoglobin and hematocrit, drainage amount, transfusion frequency, mean transfusion volume, and blood loss, as well as complications were compared between the groups. RESULTS: Drainage amount was 558.08±296.29 ml in IVU, and 498.39±199.70 ml in IAU; there was less drainage in IAU than in IVU, but without significance (p=0.262). Moreover, the drainage amount was 1,110.39±396.23 ml in IVB and 827.14±282.47 ml in IAB, which was significantly lower in IAB (p=0.000). Transfusion frequency was 5 patients (10.0%) in IVU and 2 patients (4.5%) in IAU, but without significant difference (p=0.442). Moreover, the frequency was 16 patients (29.6%) in IVB and 1 patient (2.9%) in IAB, which was significantly lower in the IAB group (p=0.002). Mean transfusion volume was 44.80±144.71 ml in IVU and 21.80±106.86 ml in IAU, but without significant difference (p=0.389); the volume was 177.80±321.00 ml in IVB and 18.30±108.18 ml in IAB, with statistical significance (p=0.001). Blood loss was 1,318.70±724.20 ml in IVU and 963.28±454.03 ml in IAU, which was significantly lower in the IAU (p=0.006); blood loss was 1,837.40±699.70 ml in IVB, and 1,337.60±382.20 ml in IAB and it was significantly lower in IAB (p=0.000). Complications included deep vein thrombosis in one case in IVU. CONCLUSION: In TKA, IA injection of TXA significantly reduced blood loss compared with IV injection, especially in bilateral TKA.
Arthroplasty, Replacement, Knee*
;
Blood Transfusion
;
Drainage
;
Hematocrit
;
Humans
;
Joints
;
Methods
;
Sutures
;
Tranexamic Acid*
;
Venous Thrombosis
8.Comparison of Ultrasonographic Biometry and Regular Last Menstrual Period as Predictors of Day of Delivery in the Spontaneous Onset of Labor.
Suk Young KIM ; Seung Wook LIM ; Gwang Jun KIM ; Ji Sung LEE ; Byung Cheul HWANG ; Yu Duk CHOI
Korean Journal of Obstetrics and Gynecology 2001;44(5):872-876
OBJECTIVES: To evaluate whether the day of delivery for women with regular menstrual history was predicted best from the last menstrual period (LMP), crown rump length (CRL) and or biparietal diameter (BPD). METHODS: All of 561 women had estimated the day of delivery by LMP, CRL in the first trimester (In case of 217 women, it was available) and BPD in the second trimester. The accuracy of each method in predicting the day of delivery was determined. Those who were delivered after the spontaneous onset of labor were included. Differences among these methods were evaluated with nonparametric tests. RESULTS: The percentage of women who delivered within 3 days of the estimated day of delivery was 254(45.3%) and 216(38.5%) of the women with pregnancies by BPD and LMP, respectively. And within 7days of the estimated day were 408(72.7%), 390(69.5%) of the women from BPD and the LMP. In the women, the BPD estimate was significantly better predictor within the 7days of the day of delivery than LMP estimate (p=0.027). Compared to LMP estimate, CRL and BPD estimates seemed to be advanced the day of delivery about 2.6 days in CRL, and 0.9 days in BPD (p=0.004, p=0.034). But we could not find any advantage of the CRL measurement in first trimester than single BPD measurement in the second trimester for the predictor of the day of delivery. CONCLUSIONS: When the difference between the methods in predicting the day of delivery was less than 7 days, the BPD measurement was better than the last menstrual period.
Biometry*
;
Crown-Rump Length
;
Female
;
Humans
;
Pregnancy
;
Pregnancy Trimester, First
;
Pregnancy Trimester, Second
;
Ultrasonography
9.The Role of Endothelial Progenital Cells and Fibrin on Vascularization and Stability in Orbital Implant.
Jae Wook YANG ; Ho Young LEE ; Sae Gwang PARK ; Young Il YANG
Journal of the Korean Ophthalmological Society 2008;49(7):1135-1145
PURPOSE: The effects of endothelial progenitor cells (EPCs) and fibrin on fibrovascular growth into porous polyethylene orbital implants (Medpor(R) sheet) were investigated using stem cells. METHODS: EPCs were separated from human adipose fat tissue for culture. Fluorescence-activated cell sorting (FACS) was used to identify the phenotype and to analyze the purity of EPCs cultivated from human adipose tissue. Processed Medpor(R) sheets were inserted in each quadrant of the subcutaneous fat layer under the dorsal surface of 20 anesthetized athymic nude mice, using sterile methods. Medpor(R) sheets processed with endothelial progenitor cells and fibrin were inserted into the two top quadrants, a Medpor(R) sheet processed with fibrin was inserted in the lower right quadrant, and an unprocessed Medpor(R) sheet was inserted in the lower left quadrant of each mouse. The mice were sacrificed on the seventh day. The adhesiveness and blood vessel formation were quantified by weight and the number of blood cells within the Medpor(R) sheets. Hematoxylin and eosin (H&E) and toluidine blue stains were used to analyze fibrovascular and cell growth within the Medpor(R) sheets. RESULTS: The sheets processed with EPCs and fibrin were heavier and contained more white and red blood cells (p<0.001) than the other sheets. The sheets processed with fibrin alone were heavier (p<0.01) and contained more blood cells (p<0.001) than the unprocessed sheets. The degree of vessel formation and tissue adhesiveness was greatest in the group of Medpor(R) sheets processed with EPCs and fibrin. The sheets processed with fibrin only had greater tissue adhesiveness and fibrovascular proliferation than the unprocessed Medpor(R) sheets. CONCLUSIONS: Endothelial progenitor cells and fibrin applied to Medpor(R) sheets improve fibrovascular proliferation and tissue adhesiveness. When both are applied together, a synergistic effect is seen.
Adhesiveness
;
Adipose Tissue
;
Animals
;
Blood Cells
;
Blood Vessels
;
Coloring Agents
;
Eosine Yellowish-(YS)
;
Erythrocytes
;
European Continental Ancestry Group
;
Fibrin
;
Flow Cytometry
;
Glycosaminoglycans
;
Hematoxylin
;
Humans
;
Mice
;
Mice, Nude
;
Orbit
;
Orbital Implants
;
Phenotype
;
Polyethylene
;
Stem Cells
;
Subcutaneous Fat
;
Tolonium Chloride
10.Risk Factors of Recurrent Febrile Convulsion.
Gwang Wook LEE ; Byung Ho CHA ; Hwang Min KIM ; Baek Keun LIM ; Jong Soo KIM
Journal of the Korean Child Neurology Society 1999;6(2):263-268
PURPOSE: Febrile convulsion (FC) is the most common type of seizure disorder during childhood. The most frequent sequale after the first FC is the recurrence of another FC. A number of risk factors associated with the recurrence have been identified. We evaluated the factors associated with the recurrence of FC. METHOD: The recurrence rates of FC by the predictive factors of recurrence were retrospectively evaluated in a cohort of 214 Korean children who were admitted to the Pediatric Depatment of the Yonsei University Wonju College of Medicine, from January 1996 to December 1997. RESULT: The overall recurrence rate of FC was 56.1% and the cumulative rates of the recurrent cases by intervals between the initial onset and recurrence were 52.5% by 6 months, 82.5% by 12 months, and 89.2% by 24 months. When the onset of the first FC occurred less than 12 months of age, the recurrence rate (66.1%) was significantly higher than that of the other age groups of the onset (p<0.05). There were no differences in the recurrence rate by the other predictive factors-durations of the initial FC, seizure type of the initial FC, the recurrence during the first 24 hours after the initial FC, and the family histories of FC or epilepsy. CONCLUSION: We can conclude that the recurrence of FC statistically correlated with the age at onset, especially less than 12 months old. And we recommend that it may be necessary to prophylactically treat recurrence of FC if the first FC occurred at less than 12 months of age.
Child
;
Cohort Studies
;
Epilepsy
;
Gangwon-do
;
Humans
;
Infant
;
Recurrence
;
Retrospective Studies
;
Risk Factors*
;
Seizures
;
Seizures, Febrile*