A few cases of a dermatosis characterized by "music box spine" keratotic papules limited to the palms and soles have been reported. There have been several names for this dermatosis The Most commonly incorporated term is porokeratosis, but Osman et at suggested the name "spiny keratoderma of palms and soles" because the clinical, histologic and electron microscopic features of this lesion are distinct from porokeratosis. We report a case of spiny keratoderma on the digit showing a single lesion, as a variant of the classic spiny keratoderma of palms and soles.
Porokeratosis ; Skin Diseases

A few cases of reticulate acropigmentary disorders have been reported in Korea. Most of them were reticulate acropigmentation of Kitamura, but not acropigmentation symmetrica of Dohi. A 21 year-old male patient diagnosed as acropigmentation symmetrica of Dohi had been previously treated with various treatment methods unsuccessfully. Re-treatment with the Q-switched alexandrite laser(755 nm, 100nsec) showed a temporary improvement but a relapse of the lesion was experienced again. We describe a case of acropigmentation symmetrica of hi treated with the Q-switched alexandrite laser.
Humans ; Korea ; Lasers, Solid-State* ; Male ; Recurrence

This is a case report of virilizing adrenal cortical adenoma in 22 month old male patient who was diagnosed by clinical features, endocrinological studies, radiologic studies and pathologic findings. During surgery, a 40gm well-encapsulated tumor was removed from the right adrenal gland. Histologic examination revealed no capsulr invasion and a diagnosis of adrenocortical adenoma was made. He is in well condition without the clinical or laboratory evidence of recurrence at 2 years of follow up.
Adrenal Glands ; Adrenocortical Adenoma* ; Diagnosis ; Follow-Up Studies ; Humans ; Infant ; Male ; Recurrence

We report a case of solar urticaria being activated by both UVA and visible radiation and positive in passive transfer test by visible light, which was treated with sunlight and UVA radiation. A short course of treatment with sunlight produced no benificial effect. UVA phototherpy produced a rnarked increase in the minirnal urtication dose by UVA but there was no increased tolerance to sun exposure.
Intradermal Tests ; Light ; Phototherapy ; Solar System ; Sunlight* ; Urticaria*

No abstract available.
Liver Cirrhosis* ; Liver*

In this study, a total of 115 ICR male albino haired mice were used and divided into two groups(A & B) for experiment. In group A(65 mice), quantiatation of sunburn cell(SBC) production and its distribution according to the time course after ultraviolet irradiation was measured. In group B(50mice), quantitation of dose-response experiments for SBC production after ultraviolet irradiation was measured. The results were as follows: ]. SBCs were recognized by 2 hours after irradiation. There was a tendency to increase from 2 hours to 24 hours and decrease from then to l week after irradiation, 2. The increase of SBCs in lower epidermis 2 hours io 8 hours after exposure and in upper epidermis 24 hours after irradiation were statistically significant (p<0. 05). SBG number in all layers declined from 36 hours to 1 week after exposure. 3. The linear relationship which observed(y=8.09+0.85x, R=0.87) suggests a dose-response relationship between UVB dose and SBC number.
Animals ; Epidermis ; Hair ; Humans ; Male ; Mice* ; Skin* ; Sunburn*

This study was undertaken to elucidate extracutaneous hyperpigmentation of nevus of Ota by analyzing the 70 patients who visited Cryosurgery Clinic in Seoul National University Hospital between January 1984 and March 1985 This results were as follows: 1. The age of onset showed two peaks: the first one was at birth or soon after birth; 27 cases(38. 6%) and the second une was between 11 and 17 years; 37 cases (45. 7%). 2 Seventy cases were classified by Taninos method: 15.7% was type I a, 27. l% type I b, 28. 6% type Il, 20. O% type g and 8. 6% type IV 3.Fifty two out of 70 cases who were examined at the department of ophtha1rnology: pigrnentation of sclera was observed in 29 cases(55. 8%.), of conjunctiva in 18 cases(34.6%), of uveal tract in 14 cases(26. 9A), of fundus in 14 cases (26. 9%) and of optic papilla in 2 cases(3. 8%). 4 Fifty two out of 70 cases who were examined at the department of Otorhinolaryngology. pigmentation of tympanum was observed in ]0 cases(23, 8%,), of nasal mucosa in 6 cases(14. 3p,), of oral mucosa in 5 cases(11, 9%), of external auditory canal in 4 cases(9 5%) and of pharynx in 1 case(2.4%,)
Age of Onset ; Conjunctiva ; Cryosurgery ; Ear Canal ; Ear, Middle ; Humans ; Hyperpigmentation* ; Mouth Mucosa ; Nasal Mucosa ; Nevus of Ota* ; Nevus* ; Optic Disk ; Otolaryngology ; Parturition ; Pharynx ; Pigmentation ; Sclera ; Seoul ; United Nations

BACKGROUND: Metallothioneins(MTs) are ubiquitous low molecular weight cytosolic proteins with high contents of cystein that xhibit a selective binding affinity for zinc, copper and other group II heavy metal ions. In additi~on to the sequestration function and detoxification action, MTs probably participate in the cellirlar protection against. ionizing radiation and alkylating agent cytotoxicity and in cellular pn:liferation. OBJECT: The objective of this study was to evaIuate the expression of MTs and to clarify t.heir role in carcinogenesis and/or biological behaviour in the neoplasms of ectoderrnal origin. METHODS: We performed immunohistochemical studies on the surgical specimens of rnalignant rnelanoma and squamous cell carcinoma and basal cell carcinoma. The results were compared with the normal skin and mu osa and hair t,issues and raf't-on culture tissues of skin and mucosal keratinocytes. RESULTS: 1) MTs were strongly expressed in epidermal basal cells of the normal skin and raft-on cultured artificial skin They were also rnore weakly expressed in epithelial basal cells of the normal mucosa and raft on cultured artificial mucosa and in matrix cells of the normal hair. 2) In rnalignant melanoma, MTs were meaningfully expressed, i.e., a strong expression was seen in the lesions showing a rapid vertical growth phase with fatal out,comes, but a weak expression in the cases whose precursor lesions were thought as dysplastic nevi, compared to the negative finding of norrnal melanocyt,es. The strong expression in a case of congenit.al rnelanocyt.ic nevus is considered as the activation of nevoid melanocytes. 3) MTs were weakly expressed in squarnous cell carcinoma with a diffuse aattern within the tumor mass. St,rong expression of MTs was particularly apparent in the poorl. differentiated squamous cell carcinoma and at the growing border of well differentiated squamous cell carcinoma. 4) In basal cell carcinoma, MTs were rather weakly expressed in solid cireumscribed types with a diffuse pattern and in cystic type with a patchy pattern. However they were not expressed in the solid infiltrative type. CONCLUSION: From these resuilts, we concluded that MTs were ubiquitously present in possible stem cells of various epithelial tissues except melanocytes irrespective of normal or artificial skin and/or mucosa including norrnal hair tissues. In the neoplasms of ectodermal origin, MTs might be involved in the invasive growth of tumor cells in the malignant melanoma and squamous cell carcinoma. It was implied that the role of MTs in basal cell carcinoma might be related to early events of hasal cell carcinogeresis and its down regulating tendency could be possible in its infil trative stage.
Carcinogenesis ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Copper ; Cytosol ; Dysplastic Nevus Syndrome ; Ectoderm* ; Hair ; Ions ; Keratinocytes ; Melanocytes ; Melanoma ; Metallothionein* ; Molecular Weight ; Mucous Membrane ; Nevus ; Radiation, Ionizing ; Skin ; Skin, Artificial ; Stem Cells ; Zinc

Solar urticaria is an uncommon disorder characterized by rapid development of urticarial reaction in areas of skin exposed to nonizing electromagnetic radiation. Herber and Baer classified solar urticaria into eight types on the basis of action spectrum and passive or reverse passive transfer ability. We report two cases of type ]g solar urticaria which were activated by visible light and negative in both passive and reverse passive transfer test.
Electromagnetic Radiation ; Intradermal Tests ; Light ; Skin ; Transfer (Psychology) ; Urticaria*

We report two familial cases of reticulate acropigmentation of kitamura in 20-year-old male and 29-year-old female patients in which reticualte, brownish, slightly depressed pigmentation developed on acral parts of extremities and subsequently extended proximally. Characteristic pits and breaks on palms and soles were noted. Histologic findings revealed epidermal atrophy and enlongation of rete ridges with large amounts of melanin. Electron microscopic findings showed increased melanogenesis in melanocytes and numerous melanosomes and melanosome complex in keratinocytes.
Adult ; Atrophy ; Extremities ; Female ; Humans ; Keratinocytes ; Male ; Melanins ; Melanocytes ; Melanosomes ; Pigmentation ; Young Adult