This study was done to study the effect of UVA radiation upon sunburn cell formation by UVB. In this study a total of 67 ICR male albino haired mice were used. The results were as follows: 1. UVA radiation produce a little or no sunburn cell in doses 5 J/cm(2), 10 J/cm(2), and 15 J/cm(2). 2. Preirradiation of UVA 5 J/cm, 10 J/cm(2), 15 J/cm(2) had no effect on the sunburn cell formation by UVB 20 mJ/cm(2), 80 mj/cm(2)
Animals ; Hair ; Humans ; Male ; Mice ; Sunburn*

We report two familial cases of reticulate acropigmentation of kitamura in 20-year-old male and 29-year-old female patients in which reticualte, brownish, slightly depressed pigmentation developed on acral parts of extremities and subsequently extended proximally. Characteristic pits and breaks on palms and soles were noted. Histologic findings revealed epidermal atrophy and enlongation of rete ridges with large amounts of melanin. Electron microscopic findings showed increased melanogenesis in melanocytes and numerous melanosomes and melanosome complex in keratinocytes.
Adult ; Atrophy ; Extremities ; Female ; Humans ; Keratinocytes ; Male ; Melanins ; Melanocytes ; Melanosomes ; Pigmentation ; Young Adult

We report a case of solar urticaria being activated by both UVA and visible radiation and positive in passive transfer test by visible light, which was treated with sunlight and UVA radiation. A short course of treatment with sunlight produced no benificial effect. UVA phototherpy produced a rnarked increase in the minirnal urtication dose by UVA but there was no increased tolerance to sun exposure.
Intradermal Tests ; Light ; Phototherapy ; Solar System ; Sunlight* ; Urticaria*

Solar urticaria is an uncommon disorder characterized by rapid development of urticarial reaction in areas of skin exposed to nonizing electromagnetic radiation. Herber and Baer classified solar urticaria into eight types on the basis of action spectrum and passive or reverse passive transfer ability. We report two cases of type ]g solar urticaria which were activated by visible light and negative in both passive and reverse passive transfer test.
Electromagnetic Radiation ; Intradermal Tests ; Light ; Skin ; Transfer (Psychology) ; Urticaria*

In this study, a total of 115 ICR male albino haired mice were used and divided into two groups(A & B) for experiment. In group A(65 mice), quantiatation of sunburn cell(SBC) production and its distribution according to the time course after ultraviolet irradiation was measured. In group B(50mice), quantitation of dose-response experiments for SBC production after ultraviolet irradiation was measured. The results were as follows: ]. SBCs were recognized by 2 hours after irradiation. There was a tendency to increase from 2 hours to 24 hours and decrease from then to l week after irradiation, 2. The increase of SBCs in lower epidermis 2 hours io 8 hours after exposure and in upper epidermis 24 hours after irradiation were statistically significant (p<0. 05). SBG number in all layers declined from 36 hours to 1 week after exposure. 3. The linear relationship which observed(y=8.09+0.85x, R=0.87) suggests a dose-response relationship between UVB dose and SBC number.
Animals ; Epidermis ; Hair ; Humans ; Male ; Mice* ; Skin* ; Sunburn*

OBJECTIVE: The pathogenesis of endometriosis is generally accepted that retrograde menstruation and alterations in the local pelvic immune environment. This study was performed to help elucidate what kind of role various cytokines might play in the pathogenesis of endometriosis. METHOD: Concentrations of peritoneal fluid cytokines were compared in 7 women with normal pelvic finding and 23 women with endometriosis by enzyme-linked immunosorbent assay(ELISA). The patterns of cytokine mRNA expression in 8 ovarian endometrioma and 12 superficial pelvic endometriosis lesions were investigated by reverse transcription-polymerase chain reaction(RT-PCR) amplification method. RESULT: Both IL-6 and IL-10 levels in peritoneal fluid specimens with endometriosis tended to be higher than normal. However, there were no significant differences between peritoneal fluid concentrations of IFN-gamma, TNF-alpha, IL-1beta, and IL-5 of women with and without endometriosis. The levels of IL-6 and IL-10 were significantly higher in peritoneal fluid of women with severe endometriosis compared to women with mild endometriosis. IL-1beta mRNA was expressed in all of 8 deep and 12 superficial endometriosis lesions. IL-5 and IL-6 mRNA were expressed in only two black lesions respectively, however, both were not expressed in the all deep lesions. Expressions of IL-10 mRNA occurred in one red and one black lesion while this was expressed in only one of the deep lesions. TNF-alpha mRNA was expressed in one red and one black lesion of 12 superficial lesions compared with four of the deep lesions. There was the difference between kinds of increased cytokines in the peritoneal fluid and those of expressed cytokines in the endometriotic lesions of patients with endometriosis. CONCLUSION: This study supports the concept that local immunologic factors may be important in the pathogenesis and pathophysiology of endometriosis. The pattern of cytokine mRNA expression of endometriotic lesions would seem to indicate that proinflammatory cytokines such as IL-1beta and TNF-alpha are responsible for the development or progression of endometriosis.
Ascitic Fluid ; Cytokines ; Endometriosis* ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunologic Factors ; Interleukin-10 ; Interleukin-5 ; Interleukin-6 ; Menstruation Disturbances ; RNA, Messenger* ; Tumor Necrosis Factor-alpha

No abstract available.
Candida* ; Esophagitis* ; HIV Infections* ; HIV* ; Humans

Herein we report a case of lentigo maligna that evolved into lentigo maligna melanoma. Fifteen years ago, the patient developed a pigmented lesion on the right cheek. The lesion progressed slowly, and 2 months ago, a black nodular lesion was developed in the periphery of the pigmented lesion. Histopathologic examination of the lesions revealed findings consistent with lentigo maligna and lentigo maligna melanorna. She had been performed wide excision and cheek flap for reconstruction.
Cheek ; Humans ; Hutchinson's Melanotic Freckle* ; Lentigo* ; Melanoma*

Becker's nevus or Becker's melanosis is a distinct clinical entity in which epimal thickening may be minimal and hairiness and pigmentation obvious. 1Ne report a case of 14-year-old female suffering from Beckers melanosis with multiple and extensive skin lesions. The electron microscope revealed that the melanocytes were bulky with increased melanogenesis and an increased number of melanosomes was found in the keratinocytes. In addition, a large number of melanosomes were seen individually in the keratinocytes.
Adolescent ; Female ; Humans ; Keratinocytes ; Melanocytes ; Melanosis ; Melanosomes ; Nevus* ; Pigmentation ; Skin

Dermal melanocytosis such as nevus of Ota and extensive Mongolian spots are sometimes associated with hemangiomatous changes. Ota gave the designation of phakorriatosis pigmentovascularis to a spectrum of these combinations. We oLserved four cases of phakomatosis pigmentovascularis. They showed extensive, various dermal melanocytosis and widespread nevus flammeus. They exhibited signs of involvement of the systemic organs such as abnormality of electroencephalograrn, soft tissue hypertrophy and convulsion.
Hypertrophy ; Mongolian Spot ; Neurocutaneous Syndromes* ; Nevus of Ota ; Port-Wine Stain ; Seizures