No abstract available.

No abstract available.
Gastroparesis*

No abstract available.
Gastroenterology*

Helicobacter pylori is among the most common bacterial pathogens, but it has not yet been conquered. It is related to various gastrointestinal diseases, including chronic gastritis, peptic ulcer, gastric marginal zone B cell lymphoma, and gastric cancer. The association between Helicobacter pylori infection and functional dyspepsia or gastroesophageal reflux disease is not clear. Numerous factors determine disease course and outcome, such as bacterial virulence, genotype, host immunity, and environmental factors. The eradication of Helicobacter pylori in associated gastrointestinal diseases is important for the treatment and prevention of recurrent or severe outcomes, especially in Korea where gastric cancer is prevalent.
Dyspepsia ; Gastritis ; Gastroesophageal Reflux ; Gastrointestinal Diseases* ; Genotype ; Helicobacter pylori* ; Helicobacter* ; Korea ; Lymphoma, B-Cell, Marginal Zone ; Peptic Ulcer ; Stomach Neoplasms ; Virulence

No abstract available.
Helicobacter pylori* ; Helicobacter* ; Stomach Neoplasms*

Helicobacter pylori (H. pylori) is the most common chronic bacterial infection in humans and causes many upper abdominal diseases and symptoms. Infection is more frequent and acquired at an earlier age in developing countries compared to industrialized nations. In Korea, the nation-wide seroprevalence of H. pylori infection in 1998 was higher than that of the developed countries. At the year, the seroprevalence in children (neonate~15 years) and adult (16~79 years) were 17.2% and 66.9%, respectively. However, seroprevalence in 2005 (59.6%) significantly decreased compared with that of 1998 (66.9%), and the decrease was significant in subjects aged less than 70 years, living in Seoul and Gyeonggi province (which is close to Seoul). The major route of transmission remains poorly understood. However, according to multivariate analysis, sex, age, geographic area, crowding (number of person per room) in childhood, economic status in childhood, and types of housing in childhood were significantly and independently associated with H. pylori seroprevalence. As 13 years have already passed since the nation-wide study in 1998, well designed study including infants and children is warranted to elucidate the seroprevalence, epidemiological factors, and the route of transmission of H. pylori infection in Korea.
Adult ; Aged ; Bacterial Infections ; Child ; Crowding ; Developed Countries ; Developing Countries ; Helicobacter ; Helicobacter pylori ; Housing ; Humans ; Infant ; Korea ; Multivariate Analysis ; Seroepidemiologic Studies

Despite the improvement of medical managements of peptic ulcer and decline of Helicobacter pylori infection, complications of peptic ulcer are still prevalent in clinical practice. This is because of the increased use of ulcerogenic medications such as aspirin or non-steroidal anti-inflammatory drug (NSAID) in elderly patients. Peptic ulcer complications include bleeding, perforation, penetration and gastric outlet obstruction. These complications need to be managed by multidisciplinary approaches such as combination of endoscopic treatment, radiologic embolization, or surgical treatments. In addition to using proton pump inhibitors, H. pylori eradication and discontinuing ulcerogenic medications are essential in the prevention of recurrence. Although uncommon, non-H. pylori, non-NSAID ulcers should be suspected as a potential cause in recurrent cases of peptic ulcer complications.
Aged ; Aspirin ; Gastric Outlet Obstruction ; Helicobacter pylori ; Hemorrhage ; Humans ; Peptic Ulcer Hemorrhage ; Peptic Ulcer Perforation ; Peptic Ulcer* ; Proton Pump Inhibitors ; Recurrence ; Ulcer

Systematic review and meta-analysis is a research method that tries to provide the best evidence by comprehensive searching, combining of results, and evaluating methodological quality of studies focused on the undetermined clinical question. By keeping credibility of the research process and minimizing potential bias, authors can provide precise pooled estimates. Recently, meta-analysis publications have been increasing and there is a need for critical appraisal of this flow. This review aims to provide an overview of recent trends of meta-analysis in the upper gastrointestinal diseases by quantitative and qualitative analysis.
Bias (Epidemiology) ; Gastrointestinal Diseases* ; Meta-Analysis as Topic ; Upper Gastrointestinal Tract

BACKGROUND/AIMS: Current production of knowledge and distribution of data is frequently mediated by social media in the form of unstructured text data rather than classical newspaper or journal format. Management of Helicobacter pylori infection is an important issue in Korea. However, there has been no study on the characteristics of information regarding H. pylori consumed and distributed in the social media by general population. MATERIALS AND METHODS: This study evaluated characteristics of social media data regarding H. pylori in Korea using semantic network analysis with Textom and NodeXL Pro (2015.8.11~2016.8.11, Naver, Daum, Youtube, and Twitter searching). RESULTS: Total collected data in the Textom analysis about ‘헬리코박터’ was 10,061. TF-IDF (term frequency × inverse document frequency) was as follows: ‘위암’, ‘위’, ‘감염’, ‘윌’, ‘균’, ‘치료’, ‘위궤양’, ‘원인’, ‘프로젝트’, ‘음식’, ‘세균’, ‘검사’, ‘예방’, ‘증상’, ‘건강’, ‘약’, ‘효과’. In the Twitter analysis, 96 nodes and 120 edges, and 86 unique edges were detected, suggesting low distribution of data. Misinformed data such as ‘헬리코박터-파이로리’, ‘라는-바이러스때문에’, ‘헬리코박터-프로젝트’, ‘위궤양이나-위’, ‘점막-출혈을’, ‘비롯하여-각종’, ‘부종을-억제하고’, ‘치료하는데-효과가’, ‘있습니다-또한’, ‘장티푸스-이질’, ‘등-전염성’, ‘세균이나-장’, ‘속의-세균들을’, ‘억제하는-효과가’, ‘프로젝트-윌’ were found. The most viewed movie in the Youtube analysis was ‘한국야쿠르트헬리코박터프로젝트윌그한입을경계하라_15초’ (210,577). CONCLUSIONS: Relative insufficiency, low distribution, and some misinformed data were found in some part of social media. Participation of healthcare professional is warranted to solve these issues.
Delivery of Health Care ; Helicobacter pylori* ; Helicobacter* ; Korea* ; Semantics ; Social Media

Background/Aims: Endoscopic submucosal dissection (ESD) is the first-line treatment for superficial gastrointestinal neoplasms with negligible lymph node metastasis. It has evolved through improvements in expertise and equipment, increased understanding of indications and short- and long-term outcomes, and better management of complications. This study aimed to assess and characterize the most influential publications in ESD research. Materials and Methods: We searched the top 50 most cited articles using Web of Science Core Collection (WoSCC) and Google Scholar (GS) from the inception of these services to January 2019. The top 50 Altmetric Attention Score (AAS) articles based on online media mentions were also searched. Each article was evaluated for the number of citations, title, journal, and publication year. Results: The number of citations for the top 50 WoSCC articles on ESD ranged from 37 to 199; Endoscopy published the most articles (20%). Among the top 50 GS articles, Gastrointestinal Endoscopy published the most ESD articles (34%) and the most shared AAS articles (42.6%). PubMed Central article citations in WoSCC or GS showed significant correlation with those from each metric, unlike AAS. The words with the highest relevance scores were “submucosal tunnel dissection,” “guideline,” “novel submucosal gel,” “adhesive material,” “cell sheet,” “esophageal ulcer,” “hemospray,” and “endoscopic closure,” while the following words were influential: “meta-analysis,” “esophageal stricture,” “perforation,” “bleeding,” “fibrin glue,” “artificial ulcer,” “porcine model” and “esophageal squamous cell neoplasia,” excluding “ESD.” Conclusions This study presents a detailed list of influential articles, journals, and topic words.