1.Mohs micrographic surgery in the treatment of basal cell carcinoma on the face.
Kyoung OH ; Jeong Tae KIM ; Young Ha JUNG ; Seok Kwun KIM ; Ki Ho KIM ; Gwang Yeol JOE
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(3):437-445
Most of the basal cell carcinomas (BCCs) are effectively treated using standard conventional therapeutic modalities, but the complete removal of the tumor is difficult if the subclinical extension of BCCs is deep and wide. These difficulties are solved by Mohs micrographic surgery which provides the highest possible cure rates and the lowest normal tissue loss. Mohs micrographic surgery is an ideal method for the treatment of skin cancer in that it provides unsurpassed cure rates and maximum preservation of normal tissue by complete surgical margin control. We studied 40 patients with 40 basal cell carcinomas (22 primary, 18 recurrent) treated by Mohs micrographic surgery from January, 1992 through October, 1995 at Dong-A University Hospital. We evaluated the depth and lateral margins of excision by Mohs microgrphic surgery according to the anatomic locations, histologic type, size, and primary/recurrent state of basal cell carcinomas. There was no recurrence during follow-up period up to 3 years. We can draw the guidelines for complete surgical margin control out of our results. The guidelines are as follows. 1. The frist excision should be done with lateral safety margin of 2 mm in primary BBCs. 2. The frist excision should be done with lateral safety margin of 4 mm in recurrent BBCs. 3. The frist excision should be done with lateral safety margin of 4 mm in longer than 15 mm-sized BBCs. 4. The additional excision should be done with the every 2 mm lateral safety margin until the tumor completely removed. 5. The frist excision should be done with the surgical depth to periosteum, perichondrium especially in BBCs on nose.
Carcinoma, Basal Cell*
;
Follow-Up Studies
;
Humans
;
Mohs Surgery*
;
Nose
;
Periosteum
;
Recurrence
;
Skin Neoplasms
2.Isolation of anaerobic bacteria from intraabdominal abscess and susceptibility to several beta-lactam antibiotics.
Byung Soo DO ; Gwang Yul SONG ; Jae Hwang KIM ; Hong Jin KIM ; Min Chul SHIM ; Koing Bo KWUN ; Hee Sun KIM ; Sung Kwang KIM
Journal of the Korean Society of Coloproctology 1991;7(1):15-21
No abstract available.
Abscess*
;
Anti-Bacterial Agents*
;
Bacteria, Anaerobic*
3.A Study of Subclinical Extension of Basal Cell Carcinoma by Mohs Micrographic Surgery.
Gwang Yeol JOH ; Jong Taik NAM ; Jung Ho YOON ; Ki Ho KIM ; Chung Hwan BAEK ; Hee Chang AHN ; Seok Kwun KIM
Annals of Dermatology 1995;7(2):127-133
BACKGROUND: Basal cell carcinoma(BCC) is the most common primary cutaneous neoplasm in Korea. Since the majority of BCCs occur on the head and neck and the goal of the BCC treatment is the complete removal of tumor, Mohs micrographic surgery is ideally suited for maximizing cure rate with minimizing tissue loss. OBJECTIVE: The purpose of this study is to evaluate the depth of excision as well as the lateral margins of BCC and to correlate these with the clinicopathologic aspects of the tumors. METHODS: Twenty patients with 21 BCCs (10 primary, 11 recurrent) diagnosed in the Department of Dermatology of Dong-A University Hospital from March, 1992 through December, 1993 were studied prospectively. RESULTS: 1. Sixty percent of tumors in primary BCCs in our series had a 2-mm maximal margin and 81.8% of recurrent BCC were eradicated with 4-mm or more lateral margin. 2. All the recurrent basal cell carcinomas (8 cases) measuring greater than 15-mm required more than 4-mm margin for the total removal. 3. More than 90% of BCC on the nose in our series required the removal of periosteum/perichondrium or the excision of whole layer. CONCLUSION: Mohs micrographic surgery is an appropriate tool to use in proposing guidelines for the treatment of skin cancer because the most accurate method of determining the actual extent of skin cancer can be achieved.
Carcinoma, Basal Cell*
;
Dermatology
;
Head
;
Humans
;
Korea
;
Methods
;
Mohs Surgery*
;
Neck
;
Nose
;
Prospective Studies
;
Skin Neoplasms
4.Brain Activation in Response to Visually Evoked Sexual Arousal in Male-to-Female Transsexuals: 3.0 Tesla Functional Magnetic Resonance Imaging.
Seok Kyun OH ; Gwang Won KIM ; Jong Chul YANG ; Seok Kwun KIM ; Heoung Keun KANG ; Gwang Woo JEONG
Korean Journal of Radiology 2012;13(3):257-264
OBJECTIVE: This study used functional magnetic resonance imaging (fMRI) to contrast the differential brain activation patterns in response to visual stimulation with both male and female erotic nude pictures in male-to-female (MTF) transsexuals who underwent a sex reassignment surgery. MATERIALS AND METHODS: A total of nine healthy MTF transsexuals after a sex reassignment surgery underwent fMRI on a 3.0 Tesla MR Scanner. The brain activation patterns were induced by visual stimulation with both male and female erotic nude pictures. RESULTS: The sex hormone levels of the postoperative MTF transsexuals were in the normal range of healthy heterosexual females. The brain areas, which were activated by viewing male nude pictures when compared with viewing female nude pictures, included predominantly the cerebellum, hippocampus, putamen, anterior cingulate gyrus, head of caudate nucleus, amygdala, midbrain, thalamus, insula, and body of caudate nucleus. On the other hand, brain activation induced by viewing female nude pictures was predominantly observed in the hypothalamus and the septal area. CONCLUSION: Our findings suggest that distinct brain activation patterns associated with visual sexual arousal in postoperative MTF transsexuals reflect their sexual orientation to males.
Adult
;
Arousal/physiology
;
Brain Mapping/*methods
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Erotica
;
Female
;
Gonadal Steroid Hormones/blood
;
Humans
;
Image Processing, Computer-Assisted
;
Magnetic Resonance Imaging/*methods
;
Male
;
Middle Aged
;
Photic Stimulation
;
Transsexualism/*psychology
5.Is Endoscopic Resection for Type 1 Gastric Neuroendocrine Tumors Essential for Treatment?: Multicenter, Retrospective Long-term Follow-up Results.
Han Sol LEE ; Seong Woo JEON ; Gwang Ha KIM ; Jin Il KIM ; Il Kwun CHUNG ; Sam Ryong JEE ; Heung Up KIM ; Geom Seog SEO ; Gwang Ho BAIK ; Kee Don CHOI ; Jeong Seop MOON
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2016;16(1):13-18
BACKGROUND/AIMS: Treatment of gastric neuroendocrine tumors is determined by type and size of the lesion. This study aimed to compare the long-term efficacy of observation and endoscopic resection for type 1 gastric neuroendocrine tumors without metastasis. MATERIALS AND METHODS: Among the 223 cases of gastric neuroendocrine tumors diagnosed between January 1996 and December 2011, 104 cases were type 1 gastric neuroendocrine tumors. Sixty-seven patients were treated endoscopically and 27 patients were observed without treatment. Endoscopic mucosal resection, endoscopic submucosal dissection, and polypectomy were the methods used for endoscopic treatment. Therapeutic efficacy and rates of complication and recurrence were evaluated retrospectively. RESULTS: In the endoscopic resection group, complete resection was observed in 53 patients (79.1%), and recurrence was observed in 14 patients (20.9%). On analysis of the observation group, no change was observed in 19 patients (70.4%), and tumor progression was observed in 8 patients (29.6%). Median follow-up duration was 49 months (31~210 months). No mortality was reported in either group during follow-up. CONCLUSIONS: Observation of type 1 gastric neuroendocrine tumors without metastasis yields results similar to those produced by endoscopic resection. Observation alone may be a safe treatment.
Endoscopy
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Follow-Up Studies*
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Humans
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Mortality
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Neoplasm Metastasis
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Neuroendocrine Tumors*
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Recurrence
;
Retrospective Studies*
;
Stomach
6.Endosonographic Findings of Submucosal Tumor-like Gastric Lesion Caused by Fibrotic Ulcer Healing.
Dong Jin YOUN ; Myung Soo KIM ; Young Keun YOON ; Chan Hee HAN ; Gwang An KWUN ; Jin Oh KIM ; Joo Young CHO ; Joon Seong LEE ; Moon Sung LEE ; Chan Sup SHIM
Korean Journal of Gastrointestinal Endoscopy 2000;20(6):460-463
It is known that multiple ulcers of the gastric antrum are often accompanied by marked submucosal fibrosis during the healing process, and that this may result in a deformity of the gastric wall. Thus, benign antral ulcers may be misinterpreted as intramural tumors, or even malignant ulcers when the surrounding edema is pronounced and sharply defined. It is possible for an endoscopic ultrasonography (EUS) to detect which layer has a submucosal tumor (SMT) in the five-layer structures of the digestive tract wall. In the diagnosis of SMT of the upper digestive tract, EUS allows for the visualization of the structures underlying the gastrointestinal wall in a noninvasive manner and has a great advantage over conventional modalities such as endoscopy and X-ray examination. The EUS findings of 2 cases of submucosal tumor-like gastric lesion caused by fibrotic ulcer healing are herein reported with a brief review of relevant literature.
Congenital Abnormalities
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Diagnosis
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Edema
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Endoscopy
;
Endosonography
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Fibrosis
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Gastrointestinal Tract
;
Pyloric Antrum
;
Stomach Ulcer
;
Ulcer*
7.Online Registry for Nationwide Database of Current Trend of Helicobacter pylori Eradication in Korea: Interim Analysis.
Beom Jin KIM ; Hyun Soo KIM ; Hyun Joo SONG ; Il Kwun CHUNG ; Gwang Ha KIM ; Byung Wook KIM ; Ki Nam SHIM ; Seong Woo JEON ; Yun Jin JUNG ; Chang Hun YANG ; Ji Hyun KIM ; Tae Ho KIM ; Sang Gyun KIM ; Woon Geon SHIN ; Sun Moon KIM ; Sok Won HAN ; Jun Haeng LEE ; Kyung Ho KIM ; Sue K PARK ; Byung Joo PARK ; Joongyub LEE ; Jae G KIM
Journal of Korean Medical Science 2016;31(8):1246-1253
Eradication of Helicobacter pylori using first-line therapy is becoming less effective. Subjects who had been treated for H. pylori infection were prospectively enrolled through an on-line database registry from October 2010 to December 2012. Demographic data, detection methods, treatment indication, regimens, durations, compliance, adverse events, and eradication results for H. pylori infection were collected. Data of 3,700 patients from 34 hospitals were analyzed. The overall eradication rate of the first-line therapy was 73.0%. Eradication failure was significantly associated with old age, concomitant medication, and comorbidity. Regional differences in eradication rates were observed. The most common first-line therapy was proton pump inhibitor-based triple therapy (standard triple therapy, STT) for 7 days (86.8%). The eradication rates varied with regimens, being 73% in STT, 81.8% in bismuth-based quadruple therapy, 100% in sequential therapy, and 90.3% in concomitant therapy. The eradication rate in treatment-naïve patients was higher than that in patients previously treated for H. pylori infection (73.8% vs. 58.5%, P < 0.001). The overall eradication rate for second-line therapy was 84.3%. There was no statistical difference in eradication rates among various regimens. H. pylori eradication rate using STT is decreasing in Korea and has become sub-optimal, suggesting the need for alternative regimens to improve the efficacy of first-line therapy for H. pylori infection.
Adult
;
Age Factors
;
Aged
;
Anti-Bacterial Agents/*therapeutic use
;
Databases, Factual
;
Drug Therapy, Combination
;
Female
;
Helicobacter Infections/*drug therapy/microbiology
;
Helicobacter pylori/isolation & purification
;
Humans
;
Internet
;
Logistic Models
;
Male
;
Middle Aged
;
Prospective Studies
;
Proton Pump Inhibitors/*therapeutic use
;
Registries
;
Republic of Korea
;
Treatment Outcome
8.Online Registry for Nationwide Database of Current Trend of Helicobacter pylori Eradication in Korea: Interim Analysis.
Beom Jin KIM ; Hyun Soo KIM ; Hyun Joo SONG ; Il Kwun CHUNG ; Gwang Ha KIM ; Byung Wook KIM ; Ki Nam SHIM ; Seong Woo JEON ; Yun Jin JUNG ; Chang Hun YANG ; Ji Hyun KIM ; Tae Ho KIM ; Sang Gyun KIM ; Woon Geon SHIN ; Sun Moon KIM ; Sok Won HAN ; Jun Haeng LEE ; Kyung Ho KIM ; Sue K PARK ; Byung Joo PARK ; Joongyub LEE ; Jae G KIM
Journal of Korean Medical Science 2016;31(8):1246-1253
Eradication of Helicobacter pylori using first-line therapy is becoming less effective. Subjects who had been treated for H. pylori infection were prospectively enrolled through an on-line database registry from October 2010 to December 2012. Demographic data, detection methods, treatment indication, regimens, durations, compliance, adverse events, and eradication results for H. pylori infection were collected. Data of 3,700 patients from 34 hospitals were analyzed. The overall eradication rate of the first-line therapy was 73.0%. Eradication failure was significantly associated with old age, concomitant medication, and comorbidity. Regional differences in eradication rates were observed. The most common first-line therapy was proton pump inhibitor-based triple therapy (standard triple therapy, STT) for 7 days (86.8%). The eradication rates varied with regimens, being 73% in STT, 81.8% in bismuth-based quadruple therapy, 100% in sequential therapy, and 90.3% in concomitant therapy. The eradication rate in treatment-naïve patients was higher than that in patients previously treated for H. pylori infection (73.8% vs. 58.5%, P < 0.001). The overall eradication rate for second-line therapy was 84.3%. There was no statistical difference in eradication rates among various regimens. H. pylori eradication rate using STT is decreasing in Korea and has become sub-optimal, suggesting the need for alternative regimens to improve the efficacy of first-line therapy for H. pylori infection.
Adult
;
Age Factors
;
Aged
;
Anti-Bacterial Agents/*therapeutic use
;
Databases, Factual
;
Drug Therapy, Combination
;
Female
;
Helicobacter Infections/*drug therapy/microbiology
;
Helicobacter pylori/isolation & purification
;
Humans
;
Internet
;
Logistic Models
;
Male
;
Middle Aged
;
Prospective Studies
;
Proton Pump Inhibitors/*therapeutic use
;
Registries
;
Republic of Korea
;
Treatment Outcome
9.Efficacy and Safety of Rebamipide versus Its New Formulation, AD-203, in Patients with Erosive Gastritis: A Randomized, DoubleBlind, Active Control, Noninferiority, Multicenter, Phase 3 Study
Gwang Ha KIM ; Hang Lak LEE ; Moon Kyung JOO ; Hong Jun PARK ; Sung Woo JUNG ; Ok-Jae LEE ; Hyungkil KIM ; Hoon Jai CHUN ; Soo Teik LEE ; Ji Won KIM ; Han Ho JEON ; Il-Kwun CHUNG ; Hyun-Soo KIM ; Dong Ho LEE ; Kyoung-Oh KIM ; Yun Jeong LIM ; Seun-Ja PARK ; Soo-Jeong CHO ; Byung-Wook KIM ; Kwang Hyun KO ; Seong Woo JEON ; Jae Gyu KIM ; In-Kyung SUNG ; Tae Nyeun KIM ; Jae Kyu SUNG ; Jong-Jae PARK
Gut and Liver 2021;15(6):841-850
Background/Aims:
The mucoprotective drug rebamipide is used to treat gastritis and peptic ulcers. We compared the efficacy of Mucosta Ⓡ (rebamipide 100 mg) and its new formulation, AD-203 (rebamipide 150 mg), in treating erosive gastritis.
Methods:
This double-blind, active control, noninferiority, multicenter, phase 3 clinical trial randomly assigned 475 patients with endoscopically proven erosive gastritis to two groups: AD-203 twice daily or Mucosta Ⓡ thrice daily for 2 weeks. The intention-to-treat (ITT) analysis included 454 patients (AD-203, n=229; Mucosta Ⓡ , n=225), and the per-protocol (PP) analysis included 439 patients (AD-203, n=224; Mucosta Ⓡ , n=215). The posttreatment assessments included the primary (erosion improvement rate) and secondary endpoints (erosion and edema cure rates; improvement rates of redness, hemorrhage, and gastrointestinal symptoms). Drug-related adverse events were evaluated.
Results:
According to the ITT analysis, the erosion improvement rates (posttreatment) in AD-203-treated and Mucosta Ⓡ -treated patients were 39.7% and 43.8%, respectively. According to the PP analysis, the erosion improvement rates (posttreatment) in AD-203-treated and Mucosta Ⓡ -treated patients were 39.3% and 43.7%, respectively. The one-sided 97.5% lower limit for the improvement rate difference between the study groups was −4.01% (95% confidence interval [CI], –13.09% to 5.06%) in the ITT analysis and −4.44% (95% CI, –13.65% to 4.78%) in the PP analysis. The groups did not significantly differ in the secondary endpoints in either analysis. Twenty-four AD-203-treated and 20 Mucosta Ⓡ -treated patients reported adverse events but no serious adverse drug reactions; both groups presented similar adverse event rates.
Conclusions
The new formulation of rebamipide 150 mg (AD-203) twice daily was not inferior to rebamipide 100 mg (Mucosta Ⓡ ) thrice daily. Both formulations showed a similar efficacy in treating erosive gastritis.
10.Efficacy of Itraconazole Melt-Extrusion Tablet One-week Therapy in Treatment of Hyperkeratotic Type of Tinea Pedis and/or Tinea Manus.
Kee Chan MOON ; Jai Kyoung KOH ; Baik Kee CHO ; Hyung Ok KIM ; Gun Su PARK ; Dae Gyu BYUN ; Jin Woo KIM ; In Kang JANG ; Jong Yuk YI ; Jae Bok JUN ; Tae Jin YOON ; Nack In KIM ; Kyu Suk LEE ; Chill Hwan OH ; Soo Nam KIM ; Sook Ja SON ; Yong Woo CHIN ; Dong Seok KIM ; Gwang Yeol JOE ; Won Woo LEE ; Kyung Sool KWON ; Dae Hun SUH ; Sang Eun MOON ; See Yong PARK ; Kea Jeung KIM ; Jong Suk LEE ; Eun So LEE ; Hyun Joo CHOI ; Eung Ho CHOI ; Ki Hong KIM ; Seung Hoon CHA ; Young Gull KIM ; Jung Hee HAHM ; Hae Young CHOI ; Sung Uk PARK ; Bang Soon KIM ; Sang Wahn KOO ; Byung Soo KIM ; Young Ho WON ; Han Uk KIM ; Eun Sup SONG ; Byoung Soo CHUNG ; Byung In RO ; Chang Kwun HONG ; Jagn Kue PARK ; Tae Young YOUN ; Hee Sung KIM ; Cheol Heon LEE ; Kwang Joong KIM ; Dae Won KOO ; Jong Min KIM ; Chang Woo LEE ; Hee Joon YU
Korean Journal of Dermatology 1999;37(8):1047-1056
BACKGROUND: Since the bioavailability of itraconazole capsule is influenced by patients gastric acidity, it results in treatment failure due to its low dissolution and subsequent low absorption when administered in fasting. Itraconazole Melt-Extrusion tablet has been lately developed in order to improve its dissolution profile. It is the first clinical study to evaluate the efficacy and safety of itraconazole Melt-Extrusion tablet in Korea. OBJECTIVE: This study was conducted to evaluate the efficacy and safety of itraconazole melt-extrusion tablet 400mg daily for 1 week(pulse therapy) for hyperkeratotic type of tinea pedis and manus. METHODS: A clinical and mycological investigation was made of 812 outpatients with hyperkeratotic type of tinea pedis and/or tinea manus who had visited at 52 general hospitals under the lead of the Korean Dermatological Association from June to December, 1998. Patients confirmed by clinically and microscopically as hyperkeratotic type of tinea pedis and/or tinea manus were administered 2 tablets twice a day for one week and followed up for 8 weeks from the start of the medication. RESULTS: The results were summarized as follows; 1. Clinical symptoms of hyperkeratotic type of tinea pedis and/or tinea mauns were significantly improved at the end of study, week 8(p<0.001). 2. Clinical response rate, defined as more than 50% decrease of the sum of the clinical symptom scores, was 79.3%(512/646). 3. Mycological cure rate, dafined as both culture and KOH negative at week 8, was 78.2%(244 /312). 4. 40(5.5%) patients, of the 727 patients evaluable for drug safety evaluation, were reported to have adverse event. CONCLUSION: Itraconazole Melt-Extrusion tablet 400mg/day for 1 week (pulse therapy) is effective and safe in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus.
Absorption
;
Biological Availability
;
Fasting
;
Gastric Acid
;
Hospitals, General
;
Humans
;
Itraconazole*
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Korea
;
Outpatients
;
Tablets
;
Tinea Pedis*
;
Tinea*
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Treatment Failure