The web-based PBL teaching plan in pediatrics embodies the network learning environment and learning requirements.The basic design unit is a complete real case with certain width and depth,which can stimulate the students' interests of participation and guide students into a predetermined learning area to achieve desired learning objectives.The article dwelled on the compilation and implementation of the teaching plan of children bronchopneumonia.The first part:teachers showed the case in PBL site and proposed the questions.Students made the Powerpoint after studying and discussing in groups by PBL teaching website,QQ group,SMS platform,etc.The second part:students reported and discussed in groups; the teacher provided the new information and put forward the following-up problems; students consulted the documents and materials through the network again; finally teachers made comments on the results.During the teaching,network should be fully utilized and the questions should be proposed progressively at different levels.Teacher should play a guiding role and emphasize the students' autonomous learning.

OBJECTIVETo investigate the association between plasma adiponectin and insulin resistance in OLETF rats.

METHODSTwenty male Otsuka Long-Evans Tokushima Fatty (OLETF) rats and 10 male Long-evans Tokushima Otsuka (LETO) rats underwent oral glucose tolerance test (OGTT) at 13 and 40 weeks of age. At 8, 32 and 40 weeks of age, the rats were sacrificed to measure the blood glucose, plasma insulin and adiponectin levels, and serum levels of TG, CHOL and FFA.

RESULTSThe plasma adiponectin level was significantly decreased in 8-week-old OLETF rats compared with that of LETO rats (P<0.05). The plasma insulin level, TG, CHOL, and FFA were significantly higher in OLETF rats than in LETO rats at 32 and 40 weeks of age.

CONCLUSIONA decreased plasma level of adiponectin preludes insulin resistance and is inversely correlated to insulin sensitivity. Hypoadiponectinemia may be an important reason leading to insulin resistance.

Adiponectin ; blood ; Animals ; Diabetes Mellitus, Type 2 ; blood ; metabolism ; Insulin ; pharmacology ; Insulin Resistance ; Male ; Rats ; Rats, Inbred OLETF ; Rats, Long-Evans

The clinical practice teaching reform of pediatrics based on TBL combined with medical simulation teaching model was carried out. TBL teaching plan writing under the model of medical simulation teaching was researched. The principles, requirements, contents and procedures of compiling teaching plans were formed. Emphasis should be placed on medical simulation teaching, team cooperation, humanistic quality education and humanistic skills training. The purposes of the reform were to achieve standardized operation skills, improve clinical ability, ensure medical safety, and improve the quality of medical purposes, but still the reform need further improvement in the teaching practice.