1.Correlation between force nurses' mental health and the coping style and social support under military stress
Hui REN ; Haiyan GONG ; Guoyu YANG ; Yunb LIU
Journal of Third Military Medical University 2003;0(09):-
Objective To investigate the correlation between force nurses' mental health and the coping style and social support under military stress. Methods An on-scene investigation into 138 force nurses who had participated in the military training was conducted by using a symptom checklist (SCL-90), a simple coping style questionnaire (SCSQ) and a Social Support Rating Scale (SSRS) respectively and the data were processed by t-test, correlation analysis and path analysis. Results The SCL-90 factor scores of force nurses under military stress were significantly lower than Chinese norms (P
2.Clinicopathologic features of thyroid incidental cancer
Chuanzhuo ZHANG ; Guoyu GAO ; Ming REN
Journal of Clinical Surgery 2018;26(5):360-362
Objective To analyze the related factors of thyroid incidental cancer.Methods A total of 68 patients were selected.They were with preoperative definite or highly suspected adenocarcinoma of one side thyroid gland,while the lateral was without nodules or nodules were not suspected.They were received total thyroidectomy or lymphadenectomy of cervical lymph node in Department of General Surger-y,Jiangsu Traditional Chinese Medicine Hospital between 2016-07 and 2017-07.They were divided into incidental papillary carcinoma group and non-incidental papillary carcinoma group.The related factors of thyroid incidental cancer were analyzed. Results There were no statistically significant differences in gender(P=1.000),age(P=0.750),cervical lymph node enlargement(P=1.000),diameter of primary cancer nodule(P=0.910),diameter of primary carcinoma(P=0.660),the ratio of carcinoma and nodule (P=0.560)and lateral cervical lymph node metastasis(P=1.000)between the two groups.There were statistically significant differences in complicating with other carcinoma(P=0.038),Hashimoto's thyroidi-tis(P=0.013),increase of TSH(P=0.003),the location of primary carcinoma(P=0.038),multiple or single of primary carcinoma(P=0.014),infringement of coated(P=0.021)and center cervical lymph node metastasis(P=0.044).The analysis showed that the increase of TSH and multiple primary carcino-mas were the independent risk factors for IPC.There was significant difference between the two groups in diameter of the contralateral nodules(P=0.016).There was no significant difference in multiple or single of the contralateral nodules(P=1.000).Conclusion In the cases with preoperative definite or highly suspected adenocarcinoma of one side thyroid gland accompanied with increasing of TSH and multiple pri-mary carcinomas,an increased risk of incidental cancer in the lateral adenocarcinoma should be paid at-tention.
3.The changes of serum nickel levels in rats with acute nickel carbonyl poisoning
Xiaoqiang XUAN ; Guoyu MA ; Xiufang REN ; Dongwei XU ; Qiuying WANG ; Ning CHENG
Chinese Journal of Primary Medicine and Pharmacy 2014;21(6):818-819
Objective To master the serum nickel change rule of acute nickel carbonyl poisoning in rats,and to provide laboratory support for clinical treatment of acute nickel carbonyl poisoning patients.Methods SPF rats were given nickel carbonyl (250mg/m3,500mg/m3) in static inhalation for 30min.Rats were anesthetized by ether for 15 seconds after exposure for 30min,2h,4h,8h,12h,24h,48h,72h and 7d respectively.Anatomized rats,kept blood collection 2-3mL,and separated serum 0.5-1mL.Serum nickel was detected by AA800 (American PE company).Results The average serum nickel levels of 250mg/m3 dose group at 30min,2h,4h,8h,12h,24h,48h,72h,7d were (33.69 ±2.59),(24.61 ±3.03),(27.83 ±5.69),(21.36 ±4.14),(20.39 ±4.14),(18.80 ±7.02),(14.51 ±8.21),(13.58 ± 5.78) and (12.83 ± 4.41)μg/L.30 minutes reached the peak,and was 5.30-fold of those in normal controls.There had significant differences compared with normal control(t =5.959,5.958,5.990,5.998,5.997,5.994,5.990,4.317,4.347,all P < 0.01).The average serum nickel levels of 500mg/m3 dose group at 30min,2h,4h,8h,12h,24h,48h,72h,7d were (72.22 ± 1.62),(57.78 ± 12.99),(42.25 ± 7.25),(103.77 ± 11.11),(79.04 ±12.26),(26.35 ±6.56),(18.58 ±4.92),(17.22 ±9.73),(14.59 ±5.27) μg/L.8h reached the peak,and was 16.33-fold of normal controls.The differences were significant (t =5.960,5.947,5.978,5.927,5.948,5.959,3.143,2.447,2.440,all P < 0.05).Meanwhile,there were significant differences between two groups of 30min,2h,4h,8h,12h(t =5.208,2.447,2.449,5.959,5.959,P =0.001,0.049,0.042,0.000,0.000),but there was no significant difference after 24h.Conclusion There was significant doses-effect relationship between serum nickel content of acute nickel carbonyl poisoning rats and the dosage.Nickel carbonyl or its metabolites were excreted mainly within 24h.
4.Analysis of Chronic Disease Prevention Literacy among Primary and Secondary School Students in Dalian
Li WANG ; Peng QIN ; Jieli LIN ; Mei ZHAN ; Guoyu REN ; Bo QU
Journal of China Medical University 2018;47(2):107-110
Objective To understand the current status of chronic disease prevention literacy among primary and secondary school students in Dalian and to provide evidence for developing health education regarding chronic diseases and promotion strategies in students. Methods A total of 1 058 students from four districts or counties in Dalian were investigated through a questionnaire survey using stratified cluster sampling in 2015. A multiple linear regression method from Stata 15. 0 was used to identify the influencing factors of chronic disease prevention literacy among primary and junior school students. Results The current status of chronic disease prevention literacy was 6. 62 % among primary and junior school students in Dalian,and it was higher in urban students than in those from rural areas (P <0. 001),higher in junior school than in primary school (P < 0. 001),and higher in girls than in boys (P = 0. 034). There also appeared to be a positive regression relationship with parents' higher education degrees (P < 0. 001). Conclusion The current status of chronic disease prevention literacy is low among primary and secondary school students in Dalian. We should strengthen their health literacy level, mobilize the role of their parents,and especially increase chronic disease prevention awareness and the self-care ability of the rural students.
5.Application value of biparametric magnetic resonance imaging radiomics combined with PSAD in Gleason grade group of prostate carcinoma
Dabin REN ; Yuguo WEI ; Liqiu LIU ; Zuliang XU ; Guoyu WANG
China Modern Doctor 2024;62(25):30-34,39
Objective To investigate the diagnostic value of biparametric magnetic resonance imaging(bpMRI)radiomics combined with prostate-specific antigen density(PSAD)in predicting low-grade and high-grade prostate carcinoma(PCa).Methods The clinical and imaging data of patients with PCa confirmed by pathology in Taizhou Central Hospital from June 2018 to October 2022 were retrospectively analyzed.According to Gleason grade group(GGG),GGG≤2 was defined as low-grade PCa,and GGG>2 was defined as high-grade PCa.PCa patients with different grades were randomly divided into training group and test group according to a ratio of 7∶3.Radiomics features were extracted based on T2 weighted imaging(T2WI)and apparent diffusion coefficient(ADC)sequences.Feature selection and dimensionality reduction were carried out using maximum relevance minimum redundancy,least absolute shrinkage and selection operator,and 5-fold cross validation was performed to retain the best radiomics features.Receiver operating characteristic(ROC)curve and Delong's test were used to evaluate the performance of each model.Decision curve analysis(DCA)was used to evaluate the clinical utility of the model.Results Among all the models,T2WI-ADC-PSAD combined model had the best diagnostic efficiency,the area under the curve(AUC)in training group and test group were 0.882,0.772,respectively.Delong's test showed that in training group,there was no significant difference in AUC between T2WI-ADC-PSAD model and T2WI model(P>0.05),but there were significant differences between T2WI-ADC-PSAD model and other models(P<0.05).In test group there were no significant differences in AUC between T2WI-ADC-PSAD model and other models(P>0.05).The DCA showed that the T2WI-ADC-PSAD model provided a higher net benefit for clinical decision-making when the threshold probability was less than 97%.Conclusion BpMRI radiomics combined with PSAD can improve the diagnostic efficiency of low-grade and high-grade PCa,and guide the treatment decision of patients.
6.Prognostic nutritional index application value for acute-on-chronic liver failure co-infection
Yamin WANG ; Yushan LIU ; Juan LI ; Qiao ZHANG ; Taotao YAN ; Danfeng REN ; Li ZHU ; Guoyu ZHANG ; Yuan YANG ; Jinfeng LIU ; Tianyan CHEN ; Yingren ZHAO ; Yingli HE
Chinese Journal of Hepatology 2024;32(3):235-241
Objective:To explore the predictive value of the prognostic nutritional index (PNI) in concurrently infected patients with acute-on-chronic liver failure (ACLF).Methods:220 cases with ACLF diagnosed and treated at the First Affiliated Hospital of Xi'an Jiaotong University from January 2011 to December 2016 were selected. Patients were divided into an infection and non-infection group according to whether they had co-infections during the course of the disease. Clinical data differences were compared between the two groups of patients. Binary logistic regression analysis was used to screen out influencing factors related to co-infection. The receiver operating characteristic curve was used to evaluate the predictive value of PNI for ACLF co-infection. The measurement data between groups were compared using the independent sample t-test and the Mann-Whitney U rank sum test. The enumeration data were analyzed using the Fisher exact probability test or the Pearson χ2 test. The Pearson method was performed for correlation analysis. The independent risk factors for liver failure associated with co-infection were analyzed by multivariate logistic analysis. Results:There were statistically significant differences in ascites, hepatorenal syndrome, PNI score, and albumin between the infection and the non-infection group ( P ?0.05). Among the 220 ACLF cases, 158 (71.82%) were infected with the hepatitis B virus (HBV). The incidence rate of infection during hospitalization was 69.09% (152/220). The common sites of infection were intraabdominal (57.07%) and pulmonary infection (29.29%). Pearson correlation analysis showed that PNI and MELD-Na were negatively correlated ( r ?=?-0.150, P ?0.05). Multivariate logistic analysis results showed that low PNI score ( OR=0.916, 95% CI: 0.865~0.970), ascites ( OR=4.243, 95% CI: 2.237~8.047), and hepatorenal syndrome ( OR=4.082, 95% CI : 1.106~15.067) were risk factors for ACLF co-infection ( P ?0.05). The ROC results showed that the PNI curve area (0.648) was higher than the MELD-Na score curve area (0.610, P ?0.05). The effectiveness of predicting infection risk when PNI was combined with ascites and hepatorenal syndrome complications was raised. Patients with co-infections had a good predictive effect when PNI ≤ 40.625. The sensitivity and specificity were 84.2% and 41.2%, respectively. Conclusion:Low PNI score and ACLF co-infection have a close correlation. Therefore, PNI has a certain appraisal value for ACLF co-infection.