Objective To evaluate the efficacy and safety of Xuebijing combined with corticosteroid injection treating paraquat poisoning with regression analysis. Methods 146 patients of paraquat poisoning in 3 years were divided into two groups: control group and therapeutic group. 50 patients in the control group were treated with Methylprednisolone, while 96 patients in the therapeutic group were treated with Xuebijing injection (300～400 ml/d, intravenous drip) and Methylprednisolone. The patients' clinical symptoms, signs and the levels of white blood cell (WBC), Neutrophils (N), C-reactive protein (CRP), glutamic-pyruvic transaminase (ALT), aspartate aminotransferase (AST), serum creatinine (Scr) and arterial partial pressure of oxygen were collected. And patients did chest CT examinations every three days. All the data were compared between the two groups. Results ① The biochemical indicators of the control group in the 14th day [WBC,N,CRP, and PaO2 is (16.49±4.30), (84.22±21.07), (24.58±7.06), and (83.20±22.95) respectively]were better than those in the third day[WBC, N, CRP, and PaO2 is (19.21 ±5.34), (85.04± 12.33), (27.98±6.51), and (73.42±11.43)respectively], but there was not significant difference between them(P>0.05). While the biochemical indicators of the therapeutic group in the 14th day [WBC,N, CRP, and PaO2 is (9.16 ± 3.23 ), (70.48 ± 10.79), ( 17.48 ± 4.7), and (95.04± 11.93) respectively] were much better than those in the third day [WBC,N,CRP, and PaO2 is (16.96±9.95),(84.82±9.34), (27.34± 10.03), and (89.12±9.47) respectively], and there was significant difference between them( P< 0.05 ). ② The survival rate in the control group was 32% comparing to 67.71% in the therapeutic group, showing significant difference between the two group (x2=9.588, P<0.05) . ③ The patients' chest CT examinations in the therapeutic group were better than those in the control group. Conclusion Xuebijing injection combined with methylprednisolone had good effects m treating paraquat poisoning.

This article mainly discussed that infection control is an important part of hospital management and plays an important role in medical quality management by reviewing and summarizing the development of the department of hospital infection control in nanjing general hospital.It put forward the goal and plan of the subject build in the future.

To discuss hospital infection control for laminar flow operation room. Ten measures of hospital infection control have been formulated for laminar flow operation room based on the danger factors of the surgery incision infection and the principle of the air purify process and filtration setting. A set of management system and detailed rules have been founded for the use of laminar flow operation room, to strengthen the notion that the patients are the all. It has met the requirement for the use of air-clean technique and setting, and guaranteed air purity.

Objective: In order to kuow the germicidal efficacy of orthophthalaldhyde. Methods: Carrier quantitative germicidal test and clinical use study. Results: the showed that 23℃,the average killing ratc after exposure to the stock solution of orthophthalaldhyde disinfectant for 90 min was 100% of Bacillus Subtitis Var.niger on carriers and for 10 min contact time could destroy completely the antigenicity of serum HBsAg,and for 5 min was 100% of bacteria. Incontinuous use for 10 days ,immersion in for 14 days it was no corrosion of carben steel and stainless steel apparatus, and no irritative to skin and mucous membrane. Conclusion: Orthophthalaldhyde has good germicidal efficacy and belongs actually no corrosion and no irritative disinfectant.

Objective: To inspect dynamically the air-microorganism in important hospital departments. Methods: Plate sedimentation was used for examination. Results: The average rate of reaching standard is 93.01% for the important hospital departments from 2001 to 2004.The rates of reaching standard for region Ⅰ,Ⅱ and Ⅲof the hospital were 76.89%,90.14% and 97.03%,respectively. Conclusion: The content of air-microorganism is affected by personnel flow,airy condition,season and disinfection measure.

To prevent the spread of bird flu to human,we applied four effective means of infection control: concept introduction,light-accelerant method,tracking administration,and draft of coping measures,which displayed the characteristics of infection control in scientific and affectionate ways,and enhanced the level of public health service.

Objective:To check the cleansing effect of light catalyst compound atomization in the hospital environment. Methods: Bacterium quantities were compared in the rooms treated with light catalyst compound atomization or routine cleansing. Results: In the room treated with light catalyst compound atomization,the rate of air bacterium reduction was 90.83% at 1 h,53.61% at 24 h,and 55.82% in average from 1 week to 12 weeks.Bacterium on object surfaces were kept lower for 8 weeks in the light catalyst compound sprayed room than in the routinely cleansed room.Conclusion:The light catalyst compound atomization can chronically cleanse the hospital environment without pollution.

Objective:To explore the predictive value of MB isoenzyme of creatine kinase (CK-MB) and poisoning severity score (PSS) in the clinical prognosis of patients with wasp sting.Methods:A retrospective study was conducted. The clinical data of patients who were stung by wasps admitted to emergency department of the First Affiliated Hospital of Henan University of Science and Technology from July 2017 to November 2019 were collected. The 24-hour acute physiology and chronic health evaluation Ⅱ (APACHEⅡ), CK-MB and PSS scores of the patients were collected after admission, and 28-day outcome was recorded. Spearman correlation analysis method was used to analyze the correlation between CK-MB and PSS score. Logistic regression model was used to construct joint predictors, and the receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of various indicators for 28-day prognosis of patients with wasp stings.Results:Finally 90 patients were included in the analysis. There were 67 patients survived at 28 days, and 23 dead with the 28-day mortality of 25.6%. APACHEⅡ score, CK-MB and PSS score in the death group were significantly higher than those in the survival group [APACHEⅡscore: 19.7±2.7 vs. 13.7±2.3, CK-MB (U/L): 183 (151, 243) vs. 36 (21, 75), PSS score: 17.7±2.6 vs. 9.3±4.5, all P < 0.01]. The correlation analysis showed that CK-MB and PSS score were positively correlated ( r = 0.843, P < 0.01). Logistic regression model fitted CK-MB and PSS score, and Hosmer-Lemeshow test showed that the model fitted well. ROC curve analysis showed that the area under ROC curve (AUC) of CK-MB for predicting 28-day outcome was 0.957, the sensitivity was 91.3%, and the specificity was 88.1%; the AUC of PSS score was 0.908, the sensitivity was 91.3%, and the specificity was 90.8%. The AUC of CK-MB combined with PSS score was 0.964, the sensitivity was 100%, and the specificity was 79.4%, indicating that CK-MB combined with PSS score had higher predictive value and higher sensitivity for 28-day prognosis of patients with wasp sting. Conclusions:High CK-MB level and high PSS score in early stage of wasp sting injury indicate poor prognosis. Both CK-MB and PSS score can be used as predictors for predicting the prognosis of patients with wasp stings. In addition, CK-MB combined with PSS score have greater predictive value .

Objective To explore the associated risk factors on patients with organophosphorus poisoning combine with respiratory failure secondary pulmonary infection.Methods Two hundred and twenty-four clinical data of organophosphorus poisoning combine with respiratory failure were collected from January 2009 to May 2013.Retrospectively analyzed the situation of pulmonary infection and Logistic regression model were used to analyzed the relative risk of organophosphorus poisoning combine with respiratory failure secondary pulmonary infection.Results The secondary pulmonary infection rate of organophosphorus poisoning combine with respiratory failure was 68.75％ (154/224).Logistic regression analysis showed that combined with aspiration,hand hygiene,breathing machine,the decrease of cholinesterase activity were the relative risk factors (P ＜ 0.05).Conclusions The secondary pulmonary infection rate of organophosphorus poisoning combine with respiratory failure is higher.Combined with aspiration,hand hygiene,breathing machine,the decrease of cholinesterase activity may be the relative risk factors.

Objective:To detect the interleukin-6 (IL-6) levels and expressions of applipoprotein E (ApoE) in the Alzheimer's disease (AD) patients with different body-mass indexes (BMI),and to explore the diagnotic value of 11Pittsburgh comound-B (11C-PIB) combined with 18F-fluorodeoxyglucose (18F-FDG) PET/CT imaging in AD.Methods:A total of 58 AD patients were divided into four groups according to their BMI:low BMI group(BMI <18.5 kg·m-2,n=18),normal BMI group(18.5 kg·m-2≤BMI <24.9 kg·m-2,n=13),high BMI group(24.9 kg·m-2≤BMI <29.9 kg·m-2,n=12)and obese group(BMI ≥29.9 kg·m-2,n=15).All the patients underwent PET/CT imaging (11C-PIB and 18F-FDG).The sensitivity,specificity and accuracy rate,the expression rates of ApoE (ε2,ε3,and ε4) and the levels of serum IL-6 were detected.The relationship between BMI and the expression rates of ApoE and the serum levels of IL-6 were analyzed by Spearman analysis.Results:The sensitivity,specificity,and accuracy rate of the patients in low BMI group diagnosed by 11C-PIB and 18F-FDG PET/CT were 87.5%,80.0%,and 84.6%,which were higher than those diagnosed by 11C-PIB (55.6%,50.0%,and 53.8%) or 18F-FDG (42.9%,50.0%,and 46.2%)alone (P<0.05).The serum levels of IL-6 and BMI of the AD patients had a negative correlation(r=-0.407,P=0.002).The expression rate of ApoE ε4 allelic gene(60.3%) of the AD patients was higher than those of ε2(18.9%) and ε3 allelic genes(20.7%),but there was no correlation between the BMI and the expression rates of different ApoE allelic genes of the AD patients(r=-0.028,P=0.833).Conclusion:11C-PIB and 18F-FDG PET/CT has a high diagnotic value in the AD patients.11C-PIB and 18F-FDG combinated with serum IL-6 level and BMI could diagnose and evaluate AD more exactly.