1.Development of multimodal ankle joint movement device
Yinchun LU ; Guoxing ZHU ; Lezeng DENG ; Zhong DING
Chinese Medical Equipment Journal 2003;0(12):-
Plantaris bend malformation of ankle joint,a serious epiphenomenon will occurs when patients lie on bed for a long time.A new type of ankle joint movement device is studied.Powered by electric motor with giant torque and super low velocity and controlled by timing controlling circuit,this device enable the ankle joint a 20?~ 30?back stretch and 40?~ 50?plantaris bend.Furthermore,it can set different moving angle and time according to individual conditions and can perform slow,continuous and reciprocating motion for different actual need.Patients whose ankle joints are unable or difficult to move actively can benefit from this device in preventing plantaris bend malformation of ankle joint,ankle joint stiffness and muscle atrophy of lower limb.
2.Diagnosis and clinical phenotype analysis of a case with large fragment homozygous deletion of rare β gene cluster.
Zeyan ZHONG ; Jianhong CHEN ; Dina CHEN ; Hailin HE ; Guoxing ZHONG ; Zhiyang GUAN ; Kunxiang YANG
Chinese Journal of Medical Genetics 2020;37(12):1331-1335
OBJECTIVE:
To report on a case with homozygous deletion of large β gene cluster and its clinical characteristics.
METHODS:
A total of 71 001 peripheral blood samples were subjected to capillary electrophoresis and conventional testing for common thalassemia mutations. The genotypes of suspected β gene cluster deletions were analyzed by Gap-PCR and multiplex ligation-dependent probe amplification (MLPA). Their hematological characteristics were compared by statistical analysis R software.
RESULTS:
Eighty-nine cases were detected with Chinese
CONCLUSION
The carrier rate for large fragment deletions of β gene cluster in Huizhou region is rather high, for which the value of HbF is significantly increased. Attention should be paid to screening and diagnosis of rare genotype to prevent missed diagnosis and/or misdiagnosis.
Gene Deletion
;
Homozygote
;
Humans
;
Multigene Family/genetics*
;
Phenotype
;
beta-Thalassemia/genetics*
3.Clinical evaluation on aesthetic effect of custom pressable metal ceramic abutment for dental implant restoration in anterior zone.
Qian ZHONG ; Guoxing ZHOU ; Hanbing GUANG ; Wenyong DAI ; Jing QIU ; Guoping WANG ; Zhijun ZHU ; Chunbo TANG
West China Journal of Stomatology 2013;31(4):429-433
UNLABELLEDOBJECTIVE To evaluate the aesthetic effect of restorations with custom pressable metal ceramic abutments for defective soft and hard tissue in the maxillary anterior zone.
METHODSFifty-two patients with missing anterior teeth in the maxillar were selected, who had problems such as exposure of abutment metal, excessively large angle deviation, excessively long ceramic crown and missing gingival papilla, affecting the aesthetic effect of implant denture. Custom pressable metal ceramic abutments were made on the conventional castable metal abutment surface and restored with all-ceramic crowns to overcome the blackness at the implant neck.
RESULTSClinical evaluation for aesthetic effects 3 and 6 months after the restorations were placed. In 63 restorations of 52 patients, the blackness at the implant neck were eliminated and the aesthetic effect were ideal. The gingival was in healthy condition, showing no further gingival retreat or inflammation around the implant denture.
CONCLUSIONCustom pressable metal ceramic abutments can effectively improve the aesthetic appearance of the implant denture in maxillary anterior zone.
Ceramics ; Crowns ; Dental Abutments ; Dental Implants ; Dental Porcelain ; Esthetics ; Humans ; Maxilla ; Metals
4.Phenotypic and genotypic analysis of 45 cases with Hemoglobin Q-Thailand.
Zeyan ZHONG ; Jianhong CHEN ; Zhiyang GUAN ; Hailin HE ; Guoxing ZHONG ; Kunxiang YANG
Chinese Journal of Medical Genetics 2018;35(5):723-726
OBJECTIVETo explore hematological and molecular characteristics of Hemoglobin Q-Thailand in Huizhou area of Guangdong Province.
METHODSA total of 34 977 samples were screened by capillary and agarose gel electrophoresis. Samples suspected with HbQ strips were subjected to blood cell count and DNA sequencing. Twenty three common mutations associated with α- and β-thalassemia were identified by liquid phase chip and diversion hybridization technique.
RESULTSThe carrier rate of Hb Q-Thailand in Huizhou area was 0.13%. Pedigree analysis indicated that the Hb Q-Thailand allele is linked with a leftward single a-globin gene deletion (-α). Hematological index (HGB, MCV, MCH, HbA, HbA, HbQ) of 45 heterozygous carriers of Hb Q-Thailand were (130.25±17.37) g/L, (79.81±4.97) fl, (26.38±1.48) pg, (71.37±5.07)%, (1.65±0.45)%, (26.87±4.95)%, respectively. A statistical difference was also found in their hematological index of HbA and HbA compared with 408 heterozygous carriers of -α mutation (P<0.05).
CONCLUSIONHb Q-Thailand has a high detection rate in Huizhou area. The allele is mainly in a heterozygous status and linked with -α. The Hb Q strip can be detected by hemoglobin electrophoresis. When combined with other types of thalassemia, the heterozygotes will show unique hematological parameters.