Objective To investigate the clinical efficacy and security of intravenous sequential oral voricon -azole treatment of blood diseases combined invasive fungal infections (IFI).Methods Combined blood of patients were reated with invasive fungal infections ,88 patients were randomly divided into the control group and treatment group using sequential treatment , the control group were treated with conventional anti-infective therapy , treatment group based on the use of conventional anti-infective drugs ,plus implementation of voriconazole therapy .The clinical efficacy were compared and adverse drug reactions were observed .Results The total effective rate of the treatment group was 90.91%,which was significantly higher than 70.45%of the control group (χ2 =5.906,P<0.05);the in-fection control in patients treated with time ,continuous medication and incidence of adverse events of the treatment group were significantly lower than those of the control group (t=2.019,P<0.05;t=1.987,P<0.05;χ2 =4.062, P<0.05).Conclusion Intravenous sequential oral voriconazole therapy combined blood invasive fungal infections in patients is safe ,effective,fewer adverse reactions ,which is widely used clinically .