Objective To investigate the relationship between the expression of human epidermal growth factor receptor-2 (C-erbB-2), phosphorylated protein kinase B (p-Akt) and the effect of neoadjuvant chemotherapy (NAC) in breast cancer.MethodsSelected May 2014 to December 2015 in quasi in our hospital for surgical treatment of 114 cases of patients with breast cancer research, the immunity group dyeing expression levels of C-erbB-2 and p-Akt detection NAC patients before treatment in breast cancer, its relationship with the clinicopathological features of patients, NAC recent curative effect analysis.Results114 patients c-erbB-2 positive 79 cases 69.30% p-Akt positive in 77 cases (67.54%) and breast cancer c-erbB-2 positive rate, p-Akt positive rate of main and tumor differentiation degree, the occurrence of lymph node metastasis (P<0.05);negative c-erbB-2 expression in patients with NAC total effectiveness 80.00% significantly higher than the 54.43% of positive patients (P<0.05);p-Akt negative expression patients with NAC total efficiency 75.68% significantly higher than positive patients of 55.84% (P<0.05).ConclusionThe high expression of p-Akt and C-erbB-2 protein in breast cancer tissue decreased the sensitivity of NAC treatment, and the effect was not good.

Objective To investigate the effect of curcumin on the hyperoxia-induced acute lung injury in neonatal rat.Methods A model of hyperoxia acute lung injury in neonatal rat was established by exposure to 95％ O2 for 3 days.After the model was established,40 rats were randomly divided into the treated group ( n =20) and the control group ( n =20).The 20 injured rats which were treated by curcumin ( 100 mg/( kg· d)were treated group,and the other 20 injured rats were control group.The 20 normal rats were blank group ( n =20).Lung tissues were collected for doing pathological section and measuring the levels of tumor necrosis factor(TNF)-a,interleukin(IL)-1β and myeloperoxidase(MPO) after 4 d and 7 d.Results The gross and micrographic injury of lung was milder in treated group than that in control group.The levels of TNF-α,IL-1β and MPO in treated group were significantly lower than those in control group at 4 d and 7 d ( P ＜0.05 ).Compared with the blank group,the levels of TNF-α,IL-1β and MPO in control group increased significantly at 4 d and 7 d ( P ＜ 0.01 ).Conclusion Curcumin can offer effective protection against acute lung injury induced by hyperoxia in neonatal rat.