Objective: To investigate the relationship between maternal disease in early pregnancy of women of childbearing age and congenital heart disease of neonates. Methods: A cross-sectional design was used in this study and stratified multistage random sampling method was used. A questionnaire survey was conducted in the childbearing-aged women during 2010-2013 in Shaanxi province. Propensity score (PS) matched (1∶1) analysis was used to match participants with diseases to those without disease in early pregnancy. Through the control of the confounders step by step, a logistic regression model was established to evaluate the ORs of congenital heart disease according to the independent variable of maternal disease. Results: A total of 28 680 pairs of mothers and infants were included in this study, the proportion of the women with disease in early pregnancy was 20.25% (5 807). After PS matching, 5 436 pairs were matched. After adjusting all confounding factors, the multivariable logistic regression analysis results showed that maternal disease (OR=1.86, 95%CI: 1.23-2.81), especially cold (OR=2.19, 95%CI: 1.46-3.28), gynecological disease (OR=4.74, 95%CI: 2.03-11.09) and diabetes (OR=14.00, 95%CI: 1.64-119.21), in early pregnancy were the risk factors for congenital heart disease of neonate. Conclusion In women of childbearing age, disease in early pregnancy, especially cold, gynecological disease and diabetes, can increase the risk of congenital heart disease in neonates.

Objective To examine the association between social isolation and cognitive function among the elderly living in the communities of Daqing city.Methods A total of 981 community residents aged 60 years or over,were surveyed with a questionnaire.Both Lubben Social Network Scale-6 (LSNS-6) and Montreal Congnitive Assessment (MoCA) Changsha Versions were used to respectively screen the status of social isolation and cognitive function,on these elderly.Results The average age was 71 years old for the 981 study participants.10.60％ (104/981) of the participants were assessed as having the status of social isolation,9.48％ (93/981) as having marginal family ties and 13.97％ (137/981) as having marginal friendship ties.Results from the multivariate linear regression analysis revealed that participants with higher scores of LSNS-6 presenting better cognitive function score,with a partial regression coefficient as 0.10 (P＜0.01).The MoCA scores in participants with social isolation (20.38 ± 5.54) were significantly lower than the ones without social isolation (22.10 ± 5.01) and the difference was statistically significant (P＜0.01).Social isolation was significantly related to the domain scores on visuo-spatial constructional executive functions (P=0.02),naming (P=0.03),language (P=0.01) and delayed memory functions (P＜0.01),but not with other domains as concentration (P=0.33),orientation (P=0.27) or abstraction (P=0.49).Conclusion The findings suggested that social isolation was mainly caused by the lack of friendship ties and associated with cognitive function and among the elderly in Daqing city,Heilongjiang province.