The parameters of illumination conditions include duration,illumination intensity,color temperature and so on.Different combinations of these conditions have different effects on human beings at the visual and psychological level and are related to occurrence or prevention of psychological diseases.Extension of illumination time and phase change of circadian rhythm increase the risk of bipolar disorder;changes in daytime,night or all-day illumination intensity have psychological effects,especially exposure to light at night increases risk of depression;inaddition,changes in color temperature of light also have psychological effects.This paper reviewed the effects of different illumination conditions on visual psychology.

Biologics are developing rapidly and have demonstrated their unique advantages in the treatment of many diseases. And with common administration, like oral and injection, biological products often have problems in instability, short half-life and poor utilization of the central nervous system, which limits the application scope and development of biological products. Intranasal biologics are promising strategy taking advantages in nasal administration that bypass the restrictions in vivo, like blood-brain-barrier, to improve the drug avalibility in the target site, which have potential to improve efficient delivery and the availability. According to published literature, clinical databases, industry guidelines around the world, this review highlighted the rescent progress in intranasal macromolecular drugs, intranasal vaccine and intranasal cell therapy, which were the main fields of intranasal biologics, offering perspectives suggestions for the further development of this field.