Objective To evluate Feridex-enhanced MRI in the diagnosis of focal hepatic lesions. Methods Conventional plain and Feridex-enhanced MR scanning was performed in 20 cases with suspected hepatic neoplasm.The number of lesions on T 2WI ,and the signal intensity of liver and lesions demonstrated on plain and enhanced scans were observed and analyzed.Results After the injection of Feridex,the signal intensity of normal liver tissue reduced significantly,while the signal intensity of lesions showed no marked changes,Feridex-enhanced MRI clearly displayed more lesions on T 2WI than plain scanning did.Conclusion Feridex-enhanced MRI is very sensitive in detecting focal hepatic lesions.

Objective To evaluate the dynamic imaging alteration of radiation-induced hepatic injuries after stereotactic radiotherapy (SRT) in hepatocellular carcinoma.Methods 18 healthy New Zealand white rabbits inoculated VX_2 carcinoma underwent 40 Gy SRT and divided into three groups randomly.The rabbits underwent identical plain and enhanced MR imaging after SRT 3 weeks,9 weeks and 20 weeks respectively. The signal-to-noise ratios of irradiation area and the surrounding normal liver on T_1WI and T_2WI imaging were calculated;The percentage enhancement of the hepatic injuried areas and the surrouding livers after Gd-DTPA enhanced was also calculated.Results After radiotherapy three weeks, the signal-to-noise ratios of irradiation areas on T_1WI and T_2WI were no difference between normal liver tissue and irradiation area; there were significant difference between normal liver tissues in radiotherapy nine weeks and twenty weeks; The difference in the signal-to-noise ratios of irradiation area were significant between after three weeks and nine weeks, twenty weeks. There were no difference in the signal-to-noise ratios of irradiation area between nine weeks and twenty weeks.The percentage enhancement of the hepatic injuries area have significant difference in arterial phase between three weeks and twenty weeks and between nine weeks and twenty weeks;The difference in portal and delay phase were significant between three weeks and nine weeks, twenty weeks, there were no difference between nine weeks and twenty weeks.Conclusion Dynamic enhanced and unenhanced MR imaging can reflect the pathological background of radiation-induced hepatic injuries in different phases.

Objective To investigate and analyze the application of narcotic drugs in the our hospital from 2011 to 2013, in order to provide references for rational use of narcotic drugs in clinical practice. Methods The application da-ta of narcotic drugs in our hospital from 2011 to 2013 were collected and analyzed from the hospital information sys-tem, adverse reactions of narcotic drugs were collected from clinical pharmacy support. Results The consumption sum of narcotic drugs increased year by year. Pethidine injection and tablet consumption were the largest, morphine agents consumption were relatively stable, fentanyl and remifentanil consumption also increased year by year, narcotic drugs had different adverse reactions. Conclusion With the implementation of“three-step ladder for cancer pain” and estab-lishment of“good pain management ward”, the utilization of narcotic drugs in our hospital will be more reasonable.

Objective To provide objective parameters for differentiating pancreatic cystic tumors via using computed tomography texture analysis (CTTA) to quantify the special imaging features of pancreatic cystadenomas.Methods Enhanced CT images of pancreas from patients who were admitted in Department of Radiology in First Hospital affiliated with Zhejiang University and First People's Hospital of Hangzhou City and pathologically diagnosed as pancreatic serous cystadenomas (n =48) and mucinous cystadenomas (n =34) from January 2009 to December 2016 were retrospectively analyzed.Regions of interest were drawn on the parenchymal phase CT images in 5 slices according to the border of the tumors.Mean grey level intensity (M),variance (V),entropy (E),skewness (Ske) and kurtosis (Kur) were obtained from fine texture (σ =1.0) to coarse texture (σ =2.5).Receiver operating characteristic (ROC) curve for texture parameters with statistically difference was drawn,and the area under curve (AUC),diagnostic sensitivity and specificity were calculated.The diagnostic accuracy of senior and junior doctors was compared with the traditional CT analysis method.Results Reliability coefficient of the two radiologists was 0.809 ～ 0.997 with high consistency.Compared with mucinous cystic tumors,serous cystadenomas had a significantly different V (5.93 ± 9.02 vs 1.29±0.62),E (2.39±0.61 vs2.02±0.39) and Kur(30.18 ±42.55 vs 8.80-±4.34) in Ske0 of 2.5 (P ＜0.05),and there were no statistically significant differences on other parameters.The AUC of differential parameters for diagnosing two kinds of cystic tumors ranged from 0.56 to 0.84.The diagnostic accuracy of the traditional CT analysis method by junior doctor and senior radiologist was 60％ and 71％,respectively.Conclusions CTTA can not only effectively quantify the heterogeneity of pancreatic cystadenomas,but also is effective in the differentiation.