The paper reviewed basic concepts of corporate governance.Based on these concepts,the authors proposed the general strategy and practices for introducing corporate governance structure at the hospital,and stated key characteristics of such a structural reform,thus making worthwhile attempts to this direction.

B-cell specific moloney leukemia virus insertion site 1(Bmi-1)gene is a core member of the polycomb group genes,considered to be a proto-oncogene;Bmi-1 plays an important role in cell self-renewal, proliferation and apoptosis. Several studies have shown that Bmi-1 is highly expressed in non-small cell lung cancer;furthermore,the expression level of Bmi-1 is closely related to the occurrence,development,incursion and prognosis of non-small cell lung cancer. Bmi-1 is expected to become a novel tumor molecular marker,and provides a new direction for the treatment of non-small cell lung cancer.

With the deepening of the lung cancer molecular biology research,small molecular targets antitumor drugs make breakthrough progress,the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is one of the most attention drug.A series studies show that EGFR-TKI can enhance the antitumor activity of ionizing radiation.Therefore,EGFR-TKI combined with radiotherapy alone for poor-risk patients appears survival benefit,but can't ignore the lung toxicity.However,there is a big contro-versy that EGFR-TKI combined with chemoradiotherapy for locally advanced NSCLC.

Studies confirm that gefitinib treatment of epidermal growth factor receptor(EGFR)muta-tions for patients with non-small cell lung cancer(NSCLC)has a clear effect,and with radiotherapy sensitiza-tion effect. Many studies both at home and abroad show that gefitinib combined with radiotherapy can signifi-cantly improve the survival times of patients,especially for the elderly patients or the patients with brain metas-tases,which has fewer adverse reactions and with higher life qualities. Therefore,gefitinib combined with radiotherapy will be an effective treatment for the patients with advanced NSCLC.

Objective To evaluate the effect of Beijing' s separation of clinic from pharmacy reform.Methods Use difference-in-difference method based on dataset on patients having Urban Worker Medical Insurance from twelve state-owned hospitals.Results The reform incurs a decrease in the outpatient and inpatient expenditure on medicine per visit (30％ and 21％,respectively),a decline in hospital's pharmaceutical ratio (9 percentages and 4 percentages,respectively); reduces the outpatient and inpatient expenditure per visit (19 ％ and 8 ％,respectively),with a decrease in the out-of-pocket part (23％ and 3％,respectively),and a slight increase in the Medical Insurance's part (2％); raises hospital's turnover (11％),outpatient's visits (22％),and inpatient visits (43％).Conclusion The reform encourages physicians to prescribe more scientifically,and hence reduces patient 's expenditure on medicine and hospital's pharmaceutical ratio; leads to a decrease in patience' s expenditure per visit;raises hospital's turnover; and doesn't cause a significant increase in the expenditure from social medical insurance.

The paper introduced the hospital's attempt to build a scientific and practical set of performance evaluation system based on KPI.The system determines the quantitative indicators for the efficiency and performance of each department,and effectively helps accomplish common objectives of the hospital and its departments,playing a key role in the sustaimble development of the hospital.

Objective To learn the clinicians'attitude towards the “Drug and Medical Service Separation” reform in Beijing.Methods A number of pilot hospitals of “Drug and Medical Service Separation” reform in Beijing were pinpointed,for a random questionnaires survey among 800 clinicians,to learn their awareness,evaluation and attitudes to the reform.Results The clinicians were found with good awareness and understanding of the reform,with an awareness rate of 99.5％ ; 72.0％ of them hold that the pricing of “medical service charge” of the reform as reasonable; most of them believe that the reform plays a positive role in relieving the difficulties of seeing doctors and affordability of medical treatment; their approval rate for the reform pilot project is 97.3％; their satisfaction for the reform implementation is 90.8％,and their support for full implementation of the reform is 94.0％.Conclusion The clinicians from those pilot hospitals are sufficiently aware of and understand this policy,and are supportive of the pilot with useful suggestions.The recommended strengthened publicity and training,higher medical service charges,better pay for medical workers,improved incentive mechanism and evaluation mechanism,and better clinicians' satisfaction.

Objective To evaluate the relationship between the expression of MMP2, type IV callagen, and invasion and metastasis of gastric cancer． Mothods The expression of MMP2 and Type IV collagen was observed by using immunohistochemistry technique． Results The MMP2 expression clearly appeared in the poordifferentiated adenocarcinoma and tubular adenocarcinoma(85．7 %, 77．7 % )． Type IV collagen destruction was observed simultaneously． MMP2 was highly expressed in patients with cancer embolus in blood vessel and lymphatic vessel or with lymph node metastasis (83．3 %, 86．7 % )． Conclutions The high expression of MMP2 was significantly associated with infiltration and metastasis of gartric cancer． The extracellular matrix, especially type IV collagen was destructed in the cases of high expression of MMP2． These rusults suggest that monitoring the level of MMP2 expression may be an index for evaluation of prognosis．

Granular cell tumor of the breast (GCTB) is a rare tumor which stems from Schwann cells.It is a largely benign tumor,but in the literature extremely infrequent cases can exhibit malignant characteristics.It tends to a particular problem as its characteristics are similar with breast carcinoma macroscopically,clinically,and radiologically.Typically,GCTB is benign and solitary lesion,yet including atypical GCTB and malignant GCTB,they can co-localize with breast malignancies multicentricity.The histopathological and immunohistochemical detection is the gold standard for diagnosis of GCTB up to now.And local expanded resection is the main treatment method at present.

Objective To observe the effect of cinobufotalin freeze-dry powder on heart rate ( HR ) and electrocardiogram ( ECG) of SD rats and to provide experimental basis for monitoring its adverse effect on heart in clinical application. Methods The drug was administered into external jugular vein at constant speed throughout the whole experiment;standard-Ⅱ limb lead monitored the HR and ECG, and then the changes in HR and ECG before and after administration of cinobufotalin were compared. Results Thirty minutes after administration of cinobufotalin injection and cinobufotalin freeze-dry powder at middle dose and high dose, HR of the rats was significantly increased as compared with blank control group[(469±40) bpm, (466±29) bpm and (484±40) bpm vs. (411±17) bpm] (P<0. 05), but soon afterwards, it returned to normal. A small number of rats also developed arrhythmia. In addition, administration of cinobufotalin significantly shortened the P-R interval[blank control group: (46. 90±3. 90) ms, cinobufotalin injection administration group: (39. 70± 2. 54) ms;middle dose of cnobufotalin freeze-dry powder administration group: (37. 70±3. 77) ms; high dose of cinobufotalin freeze-dry powder administration group:(39. 30±7. 12) ms] and Q-T interval[blank control group:(61. 29±9. 46) ms;middle dose of cinobufotalin freeze-dry powder administration group: (55. 13±4. 67) ms; high dose of cinobufotalin freeze-dry powder administration group:(51.75±11. 53) ms] (P<0. 05), but QRS and S-T were unchanged (P>0. 05). Conclusion Cinobufotalin freeze-dry powder has some side effects on rat heart and can increase HR, even lead to arrhythmia.