Objective To investigate the influence of Tangshenbao Decoction on oxidation irritable reaction and pathological changes of renal cortex in diabetic rats. Methods The diabetic models were made by the intraperitoneal injection of streptozotocin. Then the rats were treated with Tangshenbao Decoction (Chinese herbs group) and Ramipril (western medicine group) respectively for eight weeks. Observe the oxidation irritable reaction and pathological changes of renal cortex in diabetic rats. Results The Chinese herbs group can decrease the urine microalbumin, improve the activity of SOD in renal cortex, reduce the content of MDA, cut down the MGA of renal glomerulus, and has obvious effects in mitigating the oxidation damages. Conclusion Tangshenbao Decoction can decrease the excretion of urine albumin in 24 hours, mitigate the oxidation damages of kidney tissue, lighten the pathological damages of kidney, while the oxidation damages in kidney tissue may play an important role in the genesis and development of diabetic nephropathy.

To study chemical constituents contained in Tetraena mongolica. Chemical constituents were separated and purified by using such methods as silica gel, Toyopearl HW-40C and HPLC preparative chromatography. Their structures were identified by organic spectral method. One new compound was separated from T. mongolica and identified olean-11-oxo-12-en-28-ol-3beta-yl-caffeate.
Drugs, Chinese Herbal ; chemistry ; standards ; Organic Chemicals ; analysis ; chemistry ; isolation & purification ; Quality Control ; Zygophyllaceae ; chemistry