1.Comparison of the efficacy between laparoscopic and open gastrectomy for the treatment of advanced gastric cancer: a Meta analysis
Chinese Journal of Digestive Surgery 2014;13(5):325-331
Objective To compare the perioperative efficacy berween laparoscopic and open gastrectomy for the treatment of advanced gastric cancer.Methods Literatures on the comparison of the efficacy between laparoscopic and open gastrectomy were searched in the PubMed,EMBASE,the Cochrane Library,CNKI and CMCC.Articles were selected according to the inclusion criteria,and data were extracted from these trials by 2 reviewers independently and analyzed by Review Manager 5.0 software.The heterogeneity of the literatures was analyzed using the I2 test.Data were integrated by fixed or random effect model.The count data were presented by odds ratio (OR) and 95% confidence interval (95% CI).Results Twelve literatures were retrieved,including 1 published in Chinese and 11 in English,1 randomized controlled study and 11 retrospective non-randomized controlled studies.A total of 2 079 cases of advanced gastric cancer were included in this study,including 882 in the laparoscopic gastrectomy group and 1 197 in the open gastrectomy group.There were significant differences in the operation time,intraoperative blood loss,time to first flatus,time to first diet and duration of hospital stay between the 2 groups (WMD =41.33,-106.00,-0.55,-0.76,-2.62,95% CI:25.44-57.21,-120.71--91.29,-0.80--0.29,-1.29--0.23,-4.05--1.18,P < 0.05).There were no significant difference in the number of lymph nodes harvested and incidence of complications between the 2 groups (WMD =0.22,OR =0.82,95%CI:-1.48-1.93,0.62-1.08,P > 0.05).Conclusion Laparoscopic gastrectomy can be safely performed for the treatment of advanced gastric cancer,and it brings benefits to patients in perioperative period than open gastrectomy.
2.Evaluation of efficacy and safety of Gansulin 50R versus Novolin 50R in treatment of diabetic patients:A multicenter,randomized,opened and controlled clinical trial
Guoqing YANG ; Juming LU ; Changyu PAN
Chinese Journal of Diabetes 2008;0(10):-
0.05). Conclusions Gansulin 50R and Novolin 50R have similar efficacy and safty profiles in the treatment of diabetic patients.
3.Study on the relationship between N~( 5,10)-methylenetetrahydrofolate reductase gene polymorphism and the susceptibility to microangiopathy in type 2 diabetes mellitus
Guoqing YANG ; Juming LU ; Changyu PAN
Chinese Journal of Endocrinology and Metabolism 1986;0(04):-
Objective To study the relationship between the polymorphism of N 5,10 methy lenetetrahydrofolate reductase (MTHFR) gene and the susceptibility to diabetic microangiopathy (DMAP) in type 2 diabetes mellitus (DM) of Han nationality in north China. Methods By PCR RFLP, MTHFR C677T mutation was detected in 229 type 2 diabetic patients, including 102 non complication diabetics (NCD group), 67 diabetic nephropathy (DN group) and 60 diabetic retinopathy (DR group), and 62 healthy persons as control (CON group). Results The frequency of homozygous BB genotype and allele B in DN and DR were significantly higher than that in NCD and CON, but NCD and COD showed similar frequency of BB genotype and allele B. Conclusion In type 2 DM of Han nationality in north China, there is a strong correlation between the polymorphism of MTHFR gene and DMAP, and the allele B may be a susceptibile gene of DMAP.
4.The Emergency Interventional Therapy in Closed Vessel Injury Caused by the Pelvis Trauma
Zhanli ZHANG ; Guoqing LU ; Yan ZHANG
Journal of Practical Radiology 2001;0(08):-
Objective To evaluate the clinical application of interventional therapy in all kinds of pelvic trauma emergency.Methods There were tolally 16 cases in this paper(13 male and 3 female, 17~45 years old with average 31 years old). All patients had blood loose shock ( different blood pressure drop, limb pulse weakness and so on ). The blood pressure was(50~100)mmHg/(20~60) mmHg before interventional therapy,emergency selective external iliac artery, internal iliac artery and/or bleeding artery embolization and artery occlusion broken operation were performed. After operation pay attention to observe the life physical sign.Results Bleeding of internal iliac artery trunk,internal pudendum artery and obturator artery was in 8,3 and 4 cases respectively;1 case had thrombosis in external iliac artery.After emergency interventional treatment, blood pressure rose again progressively and became stability(90~120) mmHg/(60~90) mmHg,no serious complication presented.Conclusion The interventional treatment is the rapid and reasonable selection to cure the pelvic closed vessal injury and to save life.
6.Mechanism of liver metastasis in colorectal cancer
Hao WANG ; Peihua LU ; Guoqing TAO
Journal of International Oncology 2011;38(9):700-703
Liver is the main target organ of the metastasis of colorectal cancer.More and more researches demonstrate that including micro-environment of cancer,signal transduction pathway,abnormality of chromosomes and the gene which control cell proliferation and apoptosis are the most important mechanisms in liver metastasis of colorectal cancer.The metastasis of colorectal cancer is the result of all these factors.To study the mechanism can shed some light on prevention and therapy in liver metastasis of colorectal cancer.
7.Study of the relationship between plasma homocysteine thiolactone concentrations and type 2 diabetic macrovascular complications
Weijun GU ; Juming LU ; Guoqing YANG
Chinese Journal of Practical Internal Medicine 2006;0(17):-
Objective To investigate the role of homocysteine(Hcy)and homocysteine thiolactone(HcyT)in the development of macrovascular complications in patients with type 2 DM.Methods A total of 160 subjects were recruited in this study:40 healthy controls,120 with type 2 DM.Plasma Hcy levels were measured by Polarization Immunoassay(FPIA),and HcyT concentrations were monitored using high-performance liquid chromatography(HPLC)on a reversephase C18 column with ultraviolet detection.Plasma folic acid and Vitamin B12 levels were measured with radioimmunoassay method.Results Plasma Hcy and HcyT concentrations in type 2 DM patients were significantly higher than healthy controls[Hcy:9.28(7.51~11.82)?mol/L vs 5.64(5.17~8.00)?mol/L,P
8.Operation and function evaluation of XCY2002-1/200 field battle X-ray diagnosis vehicle
Zhongqing LU ; Fang MENG ; Guoqing ZHAN
Chinese Medical Equipment Journal 1989;0(01):-
Operating methods for XCY2002-1/200 field battle X-ray diagnosis vehicle are expounded. Performance of every function is evaluated. The problems and corresponding improvement are put forward.
9.APPLICATION OF ALGINIC GLUE IN TOPICAL PREPARATION I. STUDY OF THE FILM-FORMING MATERIAL
Guoqing SHEN ; Ge LU ; Xunquan LIU ; Zhijang CHEN ; Lei CHEN
Chinese Journal of Marine Drugs 1994;0(01):-
The pigmentum was prepared by using alginic glue prepared by the authors as the film - forming material. It was compared with pigmentum of Alg. Na and PVA in antibacterial activity, stability, film -forming and drug -release. The results showed that alginic glue was better than both Alg. Na and PVA. This pigmentum is an effective treatment for exudative dermatosis .
10.The Clinical Application of Percutaneous Vertebroplasty (PVP) for Treatment of Vertebral Malignant Lesion
Zhanli ZHANG ; Yan ZHANG ; Junling ZHANG ; Guoqing LU
Journal of Practical Radiology 2000;0(02):-
Objective To discuss the technique and clinical efficacy of percutaneous vertebroplasty (PVP) in the treatment of vertebral malignant lesion.Methods PVP was performed in 13 patients (15 vertibrae) including metastasis in 11 and primary tumor in 2 cases,thoracic vertebrae involved in 6 cases and lumbar vertebrae involved in 7 cases.13 cases aged between 45 and 73,median age 59 years.Under C-arm fluoroscopic or CT monitoring,needle the puncture of the vertebral body was performed through the pedicle of vertebral arch using 11~13G,15 cm long needle.Omnipaque was injected into the vertebral body to understand the information of large drain veins,then 3~7 ml of polymethylmethacrylate (PMMA) bone cement mixture(with the ratio of powder/contrast agent as 3GA9552GA9551 )was injected.The patients were followed up for 6~12 months.Results The successful rate of puncture was 100%.76.9%(10/13) of patients get better in symptoms in 3 days after operation,pain relieved in 6 months was 69.2%(9/13),in one year was 54.5%(6/11).In followed up period,CT showed the PMMA distribution was good,the vertebral body had no compression,the patients had no serious complications.Conclusion PVP is an effective and safe method for malignant lesion of vertebral body in anti-pain,preventing the compression vertebral body and secondary paraplegia.