Maspin,one kind of tumor suppressor gene,belongs to the serine proteinase inhibitor (serpin) ultra family's member.Recent studies found that it suppresses the tumor occurrence and development and has the inhibition of tumor metastasis through suppressing the tumor angiogenesis and increasing the cell adhesion,which may be a new way for gene therapy.

Objective: To assess the clinical effects of acupuncture treatment for primary dysmenorrhea. Methods: 80 cases of the patients were randomly divided into two groups by single blind to 40 cases in the acupuncture group were treated with acupuncture plus ginger-partitioned moxibustion. 40 cases in the medication group were treated with oral administration of Ibuprofen sustained release capsules. The therapeutic effects were observed after continuous treatment for 3 months. Results: The total effective rate was 85.0% in the acupuncture group and 70.0% in the medication group, with statistical significance in comparison of differences between the two groups (P<0.05) Conclusion: Acupuncture plus ginger-partitioned moxibustion is better than Ibuprofen sustained release capsules in treating dysmenorrhea.

Objective To report the reduction of eosinophil in patients with scrub typhus.Methods The clinical features of 117 patients with scrub typhus from August 2012 to December 2012 were retrospectively analyzed.Another 60 healthy control subjects were chosen as healthy controls from Jieshou People's Hospital.The change of the eosinophil count or percentage was compared between patients and healthy control subjects.Statistical analyses were performed by t test and enumeration date was compared using x2 test.Results The incidence of eosinophil reduction (count or percentage) in patients with scrub typhus was 96.6％ (113/117),which accounted for the first place in various auxiliary examination.The incidence rate of eosinophil count or percentage reduction was 96.6 ％ (113/117) before treatment,with the eosinophil count of (0.016±0.009) × 109/L.The incidence rate in healthy control group was 8.3％ (5/60) with the count of (0.085± 0.025) × 109/L.The differences between the two groups were statistically different (x2 =138.990 4,P＜0.01 ;t=15.678 3,P＜0.01).A total of 65 patients examined blood routine after 4-9 days of treatment.After treatment,the incidence of eosinophil reduction in scrub typhus group was 23.1％,and the eosinophil count increase to (0.040±0.010) × 109/L.The difference reached statistical significance compared with the incidence rate and cell count pretreatment (x2 =108.191 2,P＜0.01 ;t=2.641 2,P＜0.05).Conclusion Reduction of eosinophils in patients with scrub typhus is an important clinical characteristics,which can be used as an important clue for the diagnosis of scrub typhus.

In order to make a report on 90 cases of insomnia treated by the Wei-defensive qi-regulating and brain-strengthening needling technique,as a clinical subject of the multiple center,for assessing the preliminary standardized indications and operating methods and making an initial summary for writing the draft of the technique operation.Methods:By ratio of 1:1,the patients in conformity with the criteria were randomly divided into the experimental group and control group.In the experimental group,45 cases were treated with the Wei-defensive qi-regulating and brain-strengthening needling technique on Baihui (GV 20),Dazhui(GV 14),Shenmai(BL 62),Zhaohai(KI 6),plus ear points.In the control group,45 cases were treated with routine acupuncture on Sishencong(Ex-HN 1),Shenmen (HT 7),Sanyinjiao(SP 6),etc.The therapeutic effects in the two groups were observed and assessed in comparison.Results:The results showed cure in 15 cases.remarkable effect in 27 cases,effect in 42 cases,failure in 6 cases,and the total eriective rate in 94.4% in 90 cases of insomnia.In the three centers,the statistic management was performed based upon PSQI integral and showed significant difference(P＜0.01),and no significant difference among various groups(P＞0.01).Conclusion:The therapeutic effect in the treatment of insomnia by Wei-defensive qi-regulating and brain-strengthening needling technique is better than the control group and the therapeutic effect and methods in various centers are stable.without any deviation.

BACKGROUND:The surgical method for the treatment of unstable distal radius fracture mainly includes plate internal fixation and external fixator, but both of these two methods have the advantages and disadvantages. Which treatment is more conducive to the rehabilitation of patients, there is stil controversy.
OBJECTIVE:To evaluate the clinical effectiveness of internal fixation and external fixator for the treatment of unstable distal radius fractures.
METHODS:The relative databases and literatures were searched with the computer and hand to col ect the randomized control ed trials of internal fixation versus external fixator for the treatment of unstable distal radius fractures. After extraction literature data and quality evaluation, RevMan 5.2 software was used for system evaluation. The grip strength, disabilities of arm, shoulder&hand score, complications rates, infection rates, deformity rates and ulnar variance rates were compared between two groups.
RESULTS AND CONCLUSION:A total of 9 literatures, involving total y 524 patients were included, 286 patients in the internal fixation group and 238 patients in the external fixator group. There was no significant difference in grip strength between internal fixation group and the external fixator group. The results of Meta-analysis showed that the internal fixation group was better than the external fixator group in the aspects of disabilities of arm, shoulder&hand score, complications rate, infection rate, deformity rate and ulnar variance rate at 3 months and 1 year after treatment. The results indicate that the plate internal fixation is better than external fixator in the treatment of unstable distal radius fractures, but the large sample, double-blind, and high quality randomized control ed trials are stil needed to identify the results.

DDX5 helicase (DEAD box helicases 5), also known as P68, is an important member of an ATP dependent RNA helicase.Studies have shown that DDX5 is abnormally expressed in a variety of cancers, targeting a variety of tumor related signal pathways, regulating upstream and downstream factors to affect the occurrence, invasion and migration of tumor cells. This article describes the biological role of DDX5 in malignant tumors and provides prospects for targeted treatment of tumors.