1.Observation on the curative effect of Qufengqingre method in treatment of the patients with cough after cold
Chinese Journal of Primary Medicine and Pharmacy 2012;(8):1141-1142
ObjectiveTo explore the curative effect of Qufengqingre method in treatment of the patients with cough after cold.Methods74 patients with cough after cold were selected and randomly divided into the control group(36 cases) and the observation group (38 cases ).The control group was given roxithromycin (150 mg every time,two times every day),ketotifen( 1 mg every time,one time every night),pentoxyverine citrate(50mg every time,3 times every day).The observation group was given Qufengqingre decoction,and the decoction was boiled in water twice per dose,and mixed juice about 300 ml was abtained for morning and evening oralling.The efficacy,symptoms score and adverse reactions were observed.ResultsIn the control group,7 patients were cured,effective in 21 cases,invalid in 8 cases,and in the observation group,17 cases were cured,effective in 18 cases,invalid in 3 cases.The total effective rate of the observation group was 92.1% higher than 77.8 % of the control group ( x2 =4.16,P < 0.05 ).The cough and sputum score of the two groups before treatment was ( 2.18 ± 0.73 ) points and ( 1.09 ± 0.27 ) points,(2.26 ± 0.65 ) points and ( 1.12 ± 0.23 ) points,respectively,and after treatment was ( 1.11 ± 0.37 ) points and (0.65 ± 0.16) points,(0.72 ± 0.19 ) points and (0.35 ± 0.08 ) points.Differences in scores between the two groups before treatment were not statistically significant(t =1.29,1.31,all P > 0.05 ) ; In the two groups before and after treatment were statistically significant( t =2.68,2.59,2.43,2.41,all P < 0.05 ) ; After treatment the difference between the two groups were statistically significant( t =2.53,2.37,all P < 0.05 ).Both groups had no obviously adverse reactions.ConclusionQufengqingre method in treatment of the patients with cough after cold had remarkable effect.
2.Review of seven cases of neurobrucellosis: clinical manifestations and imaging characteristics
Meixi LI ; Guojun TAN ; Li GUO
Chinese Journal of Neurology 2014;47(7):482-486
Objective To explore the clinical features,laboratory tests,imaging characteristics of neurobrucellosis,and to improve the understanding of the disease.Methods A retrospective analysis was performed in seven patients with neurobrucellosis in our hospital from January 2002 to May 2013.Results The proportion of men and women was 6∶ 1,and the average age was 46 years.One case was attacked with the symptoms of cerebrovascular disease,another one with the symptoms of myelitis,and the other five with the symptoms of meningoencephalitis.Six had positive results of serum agglutination test,and the other one had a positive result of blood culture instead.Imaging findings lacked of specificity.There were two patients whose lesions were in the hemisphere cortex,subcortical,basal ganglia and other parts,four patients whose lesions were in the frontal lobe,one in the chest pulp,and one in both sides of cerebellum and pons.After systematical treatment,one case died,the other 6 cases recovered,and no one relapsed or got functional disability during the one-year follow-up.Conclusions Neurobrucellosis is a rare type of brucellosis,and its clinical manifestations lack of specificity,and imaging and serological detections are important for diagnosis.It is beneficial for patients if diagnosed early and treated systematically,so good understanding of this disease,early diagnosis and treatment are of great value.
3.The relationship between strategy to pseudomonas aeruginosa quorum sensing and drug resistance
Guojun LI ; Hongtao LI ; Jianxin SONG
Journal of Medical Postgraduates 2003;0(05):-
This paper underlines the composition of OS(Quorum Sensing) systems in Pesudomonas aeruginosa,the resistance mechanism of Pesudomonas aeruginosa and the relevance between QS systems and the resistance mechanism.What's more,it introduces several pathways of the interfering of QS systems to weaken the resistance.These will show a new prospect to the control of bacterial infection.
4.Targeted therapy for triple-negative breast cancer
Ronghui LI ; Caiwen DU ; Guojun ZHANG
Journal of International Oncology 2012;39(7):519-522
Triple-negative breast cancer(TNBC)is a special subtype of breast cancer which is invalid to endocrine therapy.Anti-Her2 targeted therapies such as herceptin and lapatinib are not suitable to TNBC.At present,conventional chemotherapy is the only way for the medical therapy of TNBC.Thus,searching for novel therapeutic agents for TNBC is one of hot researches of breast cancer.New targeted therapy drugs such as PARP-1 inhibitors,EGFR inhibitors,CXCR4 inhibitors,anti-angiogenesis drugs,Src tyrosine kinase inhibitor,and mTOR inhibitor are being researched.
5.Thoughts on management of scientific research instruments in the Second Military Medical University
Li DING ; Guojun CAI ; Yuanying JIANG
Chinese Journal of Medical Science Research Management 2010;23(5):320-321
As the investments from the state and society in universities increased rapidly, the scientific and technological resources gained huge promotion. However, the efficiency of some instruments remained low, and the repeated purchases of some instruments occurred frequently. Here the authors discussed about building a practical, reasonable and efficient system for lab management.
6.Examination of the Psychological Models of Asthmatic Patients.and Its Role in Asthma.
Li, WANG ; Min, ZHANG ; Guojun, HE
Journal of Shanghai Jiaotong University(Medical Science) 2000;20(4):334-336
ObjectiveThis article investigates the distribution of psychological models and its association with asthma by means of examining the psychological models of asthmatic patients.MethodsUsing 80.8 test table provided by the Institute of Applied Psychology of Suzhou University to exam the psychological models of two hundred cases in their non- acute episodes. Results From two hundred asthmatic patients we can notice the association between psychological models and the degree of asthma. In severe asthmatic patients, most was dispersed - puzzle model, occupying 65.3% (17/26),the second was intermediate model 30.7% (8/26). The majority in medium asthmatic patients was intermediate model, taking 53% (53/100), the second was dispersed-puzzle model, 34% (34/100).The easy-disturbance model was the most in mild ones, 51.4% (38/74), the intermediate model was the second, 25.6%(19/74). ConclusionThere are different psychological models in asthmatic patients. In treatments, except the medical therapy, we should direct and take active care of the patients in psychological health aspect.
7.Application of mammography in conservation therapy for breast cancer
Yangkang LI ; Guojun ZHANG ; Xiuguo ZHOU
Journal of International Oncology 2010;37(10):759-762
Among the different x-ray features of breast carcinoma, mass and calcification are the most significant reference parameters in the screening and diagnosis of early carcinoma. Mammographic follow-up after conservation therapy is the other important value of mammography for breast carcinoma. Calcification is the most important sign to show residue or recurrence of conservation therapy.
8.Factors Affecting the Preverbal Communication Skill in Prelingually Deaf Children with Cochlear Implants
Changya LI ; Guojun SHI ; Houyu ZHAO
Journal of Audiology and Speech Pathology 2017;25(4):415-418
Objective To study the factors affecting preverbal communication skill in prelingually deaf children with cochlear implants.Methods A total of 31 prelingually deaf children with cochlear implantation participated in the study.They received cochlear implantation the age of 12 months with a mean of 46.71 months.The video analysis were applied to assess the preverbal communication skill including rurn-taking,autonomy,eye contact and auditory awareness.According to the implant age,preoperative use of hearing aids,preoperative speech rehabilitation training,preoperative surgerg ear averrage residual hearing.Wilcoxon signed-rank test was used to evaluate the differences among the groups.The implant age distribution:16 cases in ≤36 months group;15 cases in >36 months group.Preoperative speech rehabilitation training (recovery time more than 3 months) : 14 cases in rehabilitation group, 17 case in no rehabilitation group.Preoperative surgerg ear averrage residual hearing:6 cases in ≤80 dB HL group;25 cases in >80 dB HL group.Preoperative use of hearing aids (use time more than 3 months) distribution: 21 cases in use group, 10 cases in no use group.Results There was statistical signifficance in preoperative use of hearing aids,preoperative speech rehabilitation training,preoperative surgerg ear averrage residual hearing(P<0.05)and there was no statistics significance group of implant age(P>0.05).Conclusion Preoperative use of hearing aids,preoperative speech rehabilitation training,preoperative surgerg ear averrage residual hearing in prelingually deaf children with cochlear implants relate with better preverbal communication still.
9.The Treatment in Phlebothrombosis of Leg by UK Infusion through Dorsal Veins of Ipsilateral Foot.
Guojun LI ; Maoheng ZU ; Hao XU
Journal of Interventional Radiology 1994;0(03):-
Purpose: Introduce the way of the treatment of deep veinous thrombosis of leg. Meerials and Methods: 26 patients (27 legs) refred for phlebothrombosis of leg, were prove by lower limb Phlebography or ECT. 100~200 thousand unit UK was infused through dorsal veins of sick leg, once or twice per day with 7 days a coure of treatment. Results: 17of 27 legs with phlebothromb0sis, were cured the successful rate 63%, 8 were improved, 30%; 2 were noneffective, 7%. No bleeding occurred 1 case of pulmonary segment embolism. Conclusion The way of the treatment of lower limb deep vein thrombosis by infusion of UK from dorsal veins of sick foot is safe and reliable.
10.Expression of EZH2 in clear cell carcinoma and its significance
Haibo LI ; He WANG ; Guojun WU
Journal of Xi'an Jiaotong University(Medical Sciences) 1981;0(02):-
Objective To explore the expression of EZH2 in clear cell carcinoma and its significance.Methods EZH2 protein expression was assessed by immunohistochemical method in tissue specimens of normal nephridium and clear cell carcinoma.Results The rate of EZH2 protein expression was 12.5% and 74.1%(P