Objective To observe the insulin resistance in pregnant patients with chronic hepatitis C.Methods 87 pregnant patients with chronic hepatitis C were chosen as observation group,while 80 healthy pregnant women were chosen as control group.The fasting blood glucose(FPG),fasting insulin(FINS) and insulin resistance index (IRS) were detected and compared in the two groups.Results The FPG,FINS and IRS of the observation group were (5.40 ± 1.01 ) mmol/L,( 69.43 ± 38.05 ) mU/L and ( 16.65 ± 12.29 ),respectively,which were significantly higher than those of the control group [ (4.53 ± 0.56 ) mmol/L,(50.54 ± 20.07 ) mU/L and ( 10.17 ± 4.66) ],respectively(t =3.26,3.87,4.01,all P＜0.05).Conclusion There was significant insulin resistance in pregnant patients with chronic hepatitis C.