Objective To investigate how to prevent deep-vein thrombosis(DVT) after total knee replace-ment(TKR).Methods Deep vein thrombosis in 87 patients after TKR from 2004 to 2007 in the Third Hospital Affiliated to Suzhou University was retrospectively analyzed.Results Amony the 87 patients,13 were found having deep vein thrombosis,5 of 38 using low-molecular-weight beparin after TKR having deep vein thrombosis,6 of 35 cases using aspirin after TKR having deep vein thrombosis,5 of the 10 eases using mechanical preventive measures having deep vein thrombosis.The difference between low-molecular-weight heparin and aspirin group was not statistically significant.Conclusion Using low-molecular-weight heparin before TKR can prevent the occurrence of deep-vein thrombosis.Using epidural anesthesia,and a low-molee-ular-weight heparin drugs or aspirin after TKR can better prevent the formation of deep-vein thrombosis.

Objective To investigate the mechanism of acute patella bone cartilage fracture,and further study its diagnosis and treatment of clinical significance.Methods Collecting 21 cases of the acute patella bone cartilage fracture from July 2005 to December 2007.Eleven patients were male and ten were female,with the mean age of 31.6 (16～46) years.All the patients were treated using the arthroseopic microfracture technique after MR examination.Results All patients were followed up 6 to 18 months,did not show patellofemoral joint pain. Evaluated by Tagner rating,excellent outcomes were found in 17 cases,good in 4 cases,satisfactory results in 100% cases.Conclusion The arthroscopic microfracture technique in treatment of the patella cartilage fracture method is simple,easy to operate,can significantly improve knee function and pain,as well as the quality of life.

Objective:To evaluate a new wax formed by laser sintering technology(SW-1)for dental use.Methods:The melting point,hardness and viscosity of SW-1,normal dental modeling wax and LongYuan's wax formed by laser sintering were tested and compared.Linear shrinkage,plastic deformation and toughness of SW-1 were estimated by national standards.Results:There were no significant differences between SW-1and the normal dental modeling wax in the properties of melting point 〔(61.1?1.63)℃,(61.7?1.96)℃〕and hardness 〔(75.2?0.62)HA,(74.0?0.54)HA〕;but when compared with melting point(78.3?1.07)℃and hardness(94.0?0.38)HA of LongYuan's wax formed by laser Sintering,those of SW-1 were significantly different.Viscosity of SW-1(2 016?136.9)MPa?s showed significant difference when compared with that of normal dental modeling wax(9.06?0.258)MPa?s and LongYuan's wax formed by laser Sintering(2 876?81.7)MPa?s.Linear shrinkage of SW-1(0.2%)met the national standards,while plastic deformation(10%,43 ℃)and toughness(broken when bent,20 ℃)of SW-1 did not meet such standards.Conclusion:SW-1 may be the proper laser sintering material for dental use,and has a good prospect in future.

OBJECTIVE: To establish an HPLC method for the determination of rebamipide in rats' plasma and colonic tissue.METHODS: The rats were assigned to receive 4 mg rebamipide chitosan capsule or its gelatin capsule or its CMC-Na solution peros.Then the plasma and colon tissue samples were taken at different time for a determination of the concentration of rebamipide by HPLC gradient elution with Cmax computed.RESULTS: The linear range for rebamipide was from 20～2 000 ng?mL-1.The average extracting recoveries of rebamipide from the plasma and the colon were 88.4% and 90.8%,respectively.After oral administration of 4 mg rebamipide chitosan capsule or its gelatin capsule or its CMC-Na solution,the Cmax of rebamipide in the colon tissue were 5 963.9,2 190.7 and 1 185.8 ng?g-1 respectively versus 252.7,949.0 and 1 023.3 ng?mL-1 respectively in plasma.CONCLUSIONS: The established HPLC gradient elution in the study can be used to determine quantitatively the rebamipide level in plasma or colon tissue for the development of its colon specific delivery preparations.

Objective To investigate the clinical application of Glissonean pedicle transection method in hepatocellular carcinoma. Methods We analyzed the clinical data of 232 cases of hepatocellular carcinoma underwent hepatic resection in our department from April 2009 to April 2013. Eighty-nine cases underwent hepatic resection by Glissonean pedicle transection method, and 143 cases underwent Pringle maneuver. Results There was no significant differences in the operation time and blood loss between the two groups (P > 0.05). However, the postoperative hospital stay time and the postoperative complications in group A were better than those in group B(P<0.05). Levels of ALT and AST in group A increased significantly slowly than those in group B. The 1, 3-year disease-free survival rates in the two groups were 87.4%, 71.1% and 85.1%, 60.0%, respectively. The 1, 3-year survival rates were 93.3%, 73.5% and 93.4%, 65.0%, respectively, with no significant differences (P>0.05). Conclusion Glissonean pedicle transection method has many advantages including effectively preventing the intraoperative bleeding, maximally reserving the remaining of liver function, decreasing the rate of tumor spread and metastasis. Meanwhile, it is a safe and effective technique for hepatectomy without dissection of the hepatic artery, portal vein and bile duct in the hepatoduodenal ligament.

Acute myeloid leukemia (AML),the most common disease in acute leukemia,is a highly heterogeneous invasive hematological disease.The t(8;21)(q22;q22) translocation is the most common chromosomal translocation in AML,generating AML1-ETO fusion gene and encoding AML1-ETO fusion protein.This article summarizes the two-hit hypothesis in AML occurrence,the pathogenesis of t(8;21)AML,all features involved in t(8;21)AML,and the function of the components in AML1-ETO fusion protein,providing important basic information for the treatment and prognosis of t(8;21)AML.Meanwhile,this article also summarizes the progress of next generation sequencing technique in leukemia,providing a new technique for the accurate therapy of (8;21)AML.

ObjectiveTo explore the effect of combined usage of expanding coronal decompressive craniectomy and sequential dural incision for treating severe bilateral frontal contusion (SBFC).Methods Forty-three patients with SBFC were randomly divided by sequential single day after hospitalization into two groups.Observation group(23 cases) treated with expanding coronal decompressive craniectomy and sequential dural incision.Control group (20 cases) treated with standard hemicraniectomy and routine dural incision.ResultsThe occurrence rate of acute cephalocele was significantly lower in observation group [ 17.4％(4/23) ] than that in control group [ 55.0％(11/20) ] (P ＜ 0.05).According to Glasgow outcome scale (GOS) score of six-month observation after operation,17 cases(73.9％,17/23) of observation group got favourable recovery or moderate deficit,other 6 cases(26.1％,6/23) got severe deficit,persistent vegetative status or death.While only 8 cases(40.0％,8/20) got favourable recovery or moderate deficit,12 cases ( 60.0％,12/20 ) got severe deficit,persistent vegetative status or death in control group.The rate of favourable recovery and moderate deficit of two groups had statistical significance (P ＜ 0.05).ConclusionCombination application of expanding coronal decompressive craniectomy and sequential dural incision is an effective method to treat patients with SBFC,and can obviously improve the rate of successful rescue and decrease the rate of mortality and disability.

OBJECTIVETo evaluate the clinical feasibility of daily quality assurance for linac radiation field by analyzing the trend of the daily testing data about parameter of radiation field.

METHODSTwo-dimensional ion chamber array Daily QA3 was used to measure the difference between the practical value and the standard value of the parameter about radiation field before commencing daily treatment. Farmer type ionization chambers from IBA Co. with DOSE1 dosimeter was used for the absolute dosimetry of photon and electron beams. Light/radiation field coincidence was checked by using films every month. The daily testing data (from 11/28/2009 to 4/8/2011) were reviewed and analyzed.

RESULTSX-ray and electron output was increasing steadily; light/radiation field coincidence, beam flatness constancy and symmetry of X- ray and electron was keeping stable.

CONCLUSIONThe procedures for daily quality assurance of linac radiation field, which will provide reference for long term linac calibration, are feasible in our experience.

Objective: To explore correlations between physical activity (PA), sedentary behavior (SB) and physical posture disorders in primary school students, and to provide reference for the prevention and correction of adverse body posture in this group. Methods: From September to December 2020, 206 children from 4 primary schools in Chaoyang District of Beijing were selected by multistage stratified cluster random sampling method. Body posture and PA were assessed using a body posture tester and a triaxial accelerometer. Children s Leisure Activity Questionnaire was used to investigate SB. Results: The detection rate of abnormal body posture in primary school students was 76.70%. PA showed positive assocation with high and low shoulder, X/O leg, pelvis forward, spine curvature and comprehensive evaluation ( β =0.17, 0.21, 0.19, 0.24, 0.19, P <0.05). SB had significant negative linear correlation with high and low shoulder, X/O leg,pelvis forward, spine curvature and comprehensive evaluation ( β = -0.24 , -0.22, -0.36, -0.24, -0.27, P <0.05). In the combination analysis, children with high PA plus low SB ( OR=2.12, 95%CI= 1.46-3.37, P <0.05) and children with low PA plus high SB had the highest and lowest advantages of qualified rate of body posture assessment,respectively. Compare with low SB and low PA( OR=1.71, 95%CI=1.41-2.74, P <0.05), high PA and high SB ( OR=1.85, 95%CI=1.38-2.86, P <0.05) had higher qualified rate of body posture assessment. Conclusion Physical activity shows positive effects on physical posture while sedentary behavior shows negative effects on physical posture. The combination of PA and SB has a counteracting or synergistic interaction effect.

ObjectiveTo investigate the clinical promoting effect of crossing nape electroacupuncture on the recovery of swallowing function and recovery from pulmonary infection in post-cerebral infarction patients with tracheotomy.MethodSixty post-cerebral infarction patients with cough reflex disorder and swallowing dysfunction associated with pulmonary infection receiving tracheotomy and tracheal intubation were subjects. They were allocated, using a random number table, to three groups, 20 cases each. In each group, the patients were enrolled in order of visits. The three groups were given the same basic treatment for fighting inflammation, resolving phlegm and improving blood supply. The crossing nape electroacupuncture group received bilateral points Fengchi (GB20), Yifeng (TE17), Dicang (ST4)-to-Jiache (ST6) and Lianquan (CV23) acupuncture with electrodes connected by left-right crossing. The acupuncture group received bilateral points Fengchi, Yifeng, Dicang-to-Jiache and Lianquan acupuncture without electrodes connected. The control group received basic treatment with Western drugs without acupuncture therapy. Observations were carried out using the Kubota’s water drinking test, the Toshima Ichiro Swallowing Assessment and the Clinical Pulmonary Infection Score. The clinical therapeutic effects were evaluated in the three groups.ResultThe therapeutic effects evaluated using the Kubota’s water drinking test and the Toshima Ichiro Swallowing Assessment were better in the crossing nape electroacupuncture group than in the acupuncture group and better in the acupuncture group than in the control group (P<0.05). The score of the Clinical Pulmonary Infection Score decreased in all the three groups. The promoting effect on recovery from pulmonary infection was marked in the crossing nape electroacupuncture group (P<0.01).ConclusionCrossing nape electroacupuncture has a marked improving effect on dysphagia in post-cerebral infarction patients with tracheotomy and tracheal intubation. It can promote recovery from pulmonary infection in post-cerebral infarction patients with cough reflex disorder receiving tracheotomy and tracheal intubation.