It has been practiced for thousands years to see the relationship between caloric restriction and health.Many experimental and clinical trials confirmed the success of this approach in extending lifespan and decreasing the risk of chronic diseases.However,besides the benefit for the body,it may also give an effort to mood and behavioral improvement.For nowadays,it has been proved that mental assessment is important and necessary before and during caloric restriction therapy.

Objective The optimal community nursing intervention methods for community patients with primary hypertension was discussed in order to promote their health. Methods System management and community intervention were applied to 140 community patients with primary hypertension for 2 years, including strengthing community communication, popularizing health knowledge, improving cognition of danger of hypertension, hypertensive disease project management, tracking and monitoring the patients with primary hypertension and medication supervision.The cognition rate of prevention and control knowledge for hypertension, hypertension-related cardiovascular complication and formation rote of hypertension control behavior were compared before and after intervention. Results The prevalence rate of the knowledge on hypertension was increased, accompanied with promoting regular medication in patients with hypertension, decreasing cardiovascular complication caused by hypertension and heightening formation rate of controlling behavior in hypertension patients.Conclusions Applying community nursing intervention is practically effective in prevention and treatment of primary hypertension, deserving promotion and application in community medical institute.

Genechip was applied to explore gene expression profile of islets in rats at various stages of pregnancy. Compared with the normal control group, differential expressions of hundreds of genes were detected during pregnancy. Reg3α gene expression was markedly increased during pregnancy, which may be related to islet regeneration.

OBJECTIVE:To systematically review the effect of CYP2C19 genetic polymorphism on lansoprazole pharmacoki-netics,and provide evidence-based reference for clinical individualized medication of lansoprazole. METHODS:Retrieved from PubMed,EMBase,Web of science,Cochrane Library and CJFD,retrospective studies about the effect of CYP2C19 genetic poly-morphism on lansoprazole pharmacokinetics were collected,Meta-analysis was performed by Rev Man 5.2 software after data ex-tract and quality evaluation. RESULTS:Totally 11 retrospective studies were included,involving 200 patients. The gene type in-cluded homozygote express metabolizers (EM),heterozygous express metabolizers (HEM) and slow metabolizers (PM). Results of Meta-analysis showed CYP2C19 polymorphism significantly affected cmax,AUC,t1/2,tmax and CL/F. The cmax and AUC in group PM were higher than group HEM and group EM;CL/F in group EM was higher than group HEM and group PM;t1/2 in group PM was higher than group HEM and group EM,while there was no significant difference in the t1/2 between group HEM and group EM;tmax in HEM and group PM were higher than group EM,while there was no significant difference in the tmax between group PM and group HEM. CONCLUSIONS:CYP2C19 genetic polymorphism shows obvious effect on lansoprazole pharmacokinetics, which is the key factor for causing efficacy of lansoprazole and individual differences among adverse reactions,and clinic should take into account individualized dose regimen of lansoprazole.

Objective:To summarize the drug interactions of haloperidol used in combination with the other drugs to provide refer-ence for safe, reasonable and effective use of haloperidol in clinics. Methods:By retrieving Micromedex? , Pubmed, CNKI and so on, the interactions between haloperidol and the other drugs were summarized and analyzed. Results:The effect of haloperidol was on do-pamine receptors, and haloperidol was mainly metabolized by hepatic cytochrome P450 ( CYP) enzymes. When haloperidol was com-bined with the other drugs, significant interactions of pharmacokinetics and pharmacodynamics were induced by affecting CYP enzymes or dopamine receptor. Conclusion:In clinical practice, the other drugs combined with haloperidol should be reasonable and careful to ensure safe, effective and rational drug use.

Objective: To explore the improvement influence of three combined exercise programs on sleep quality among college students with sleep disorders, so as to provide reference for the construction of exercise intervention programs for sleep disorder. Methods: A total of 35 college students with sleep disorders were randomly divided into AR group ( n =10), AM group ( n =8), RM group ( n =9) and CG group ( n =8). The three exercise groups were provided with exercise intervention for 8 weeks, 3 times/week , 60 min/time, and the CG group maintained previous lifestyle.Before and after the intervention,evaluation of subjective sleep quality and reduction rate of sleep disorder by PSQI, and Actigraph GT3X+ was used to monitor the changes in the objective sleep quality. Results: After the intervention,the total score of PSQI ( t =3.49, 2.31, 2.73), sleep quality score ( t =2.71, 3.00 , 5.29),sleep duration of AR group ( t =2.74), daytime dysfunction of AM group ( t =2.64) and sleep duration of RM group ( t = 2.29) significantly decreased ( P ＜0.05); The scores of sleep duration in AM group were significantly lower than those in AR group, and the scores of PSQI,sleep quality and daytime dysfunction in AM group were significantly lower than those in CG group (P<0.05). After intervention,TST ( t =-4.41, -8.37, -6.79) and SE ( t =-4.40, -5.86, -4.91) of AR group, AM group and RM group significantly increased( P <0.05), SOL ( t =4.18, 9.93), WASO ( t =2.91, 3.46) and NA ( t =4.80, 3.37) of AM group and RM group significantly decreased ( P <0.05). The changes of TST,SE and WASO in RM group were significantly higher than those in CG group, and SOL was significantly lower than those in CG group ( P <0.05). Conclusion The three kinds of combined exercise programs can improve the subjective and objective sleep quality of college students with sleep disorders, and reduce the incidence of sleep disorders; different combined exercise programs have different influence on the improvement of sleep quality of college students with sleep disorders, aerobic combined meditative movement exercise program has a prominent influence on the improvement of subjective sleep quality, and resistance combined meditative movement exercise program has a prominent influence on the improvement of objective sleep quality.

Objective:To investigate the application value of triangular modal construed for planning approach of laparoscopic local resection of liver tumors located in superior part of central liver lobe.Methods:The retrospective and descriptive study was conducted. The clinicopathological data of 10 patients who underwent local laparoscopic resection of liver tumors located in superior part of central liver lobe at the Affiliated Hospital of Qingdao University from January to June 2020 were collected. There were 6 males and 4 females, aged from 41 to 63 years, with a median age of 54 years. Preoperative triangular model was constructed for all patients to plan approach of laparoscopic local resection of liver tumors located in superior part of central liver lobe. Observation indicators: (1) preoperative general situations of patients; (2) surgical situations; (3) follow-up. Follow-up was conducted by outpatient examination or telephone interview to detect tumor recurrence and survival of patients up to February 2021. Measurement data with normal distribution were expressed as Mean± SD. Count data were expressed was absolute numbers. Results:(1) Preoperative general situations of patients: hepatocellular carcinoma was found in 7 cases, inthahepatic cholangiocarcinoma was found in 2 cases and ovarian cancer with liver metastasis was found in 1 case. Three cases had tumors located in S4a segment, 2 cases had tumors located in ventral subsegment of S8 segment, 2 cases had tumors located in dorsal subsegment of S8 segment, and 3 cases had tumors across the ventral segment of S4a+S8. The diameter of tumors was (3.4±1.0)cm. (2) Surgical situation: all the 10 patients underwent R 0 resection successfully, with no intraoperative blood transfusion or conversion to open surgery. The operation time of 10 patients was (149±59)minutes, the volume of intraoperative blood loss was (294±163)mL, the minimum surgical margin of specimen was (1.1±0.2)cm. The alanine aminotransferase was (324±151)U/L on the postoperative first day, the aspartic aminotransferase was (401±113)U/L on the postoperative first day, and the duration of postoperative hospital stay was (9±4)days. No bile leakage, hemorr-hage, reoperation or other complications occurred in all patients. (3) Follow-up: 10 patients were followed up for 7?13 months, with a median follow-up time of 11 months. All patients had no margin recurrence or distant metastasis. Conclusion:It is safe and feasible to construct triangular modal for planning approach of local laparoscopic resection of liver tumors located in superior part of central liver lobe.

Objective To investigate the predictive value of labor progress angle(AOP),fetal head descent distance(HPD)and their change rates in the outcome of vaginal trial of cesarean scar uterus.Methods A total of 170 pregnant women who underwent vaginal trial production of scar ute-rus after cesarean section were selected as study subjects,and were divided into successful group and failed group based on the trial production outcomes.Advanced oxidation processes(AOP)and head-perineum distance(HPD)were measured by ultrasound during the active phase of the first stage of labor when the cervix dilated to 4 cm and at 1 hour after the cervix dilated to 4 cm,respectively.The AOP change rate and HPD change rate after 1 hour of progress were calculated.The receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of AOP,HPD and their change rates in the outcome of vaginal trial production of scar uterus after cesarean section.Delong test was used to compare the differences in area under curves(AUCs).Results Among 170 pregnant women with scarred uterus after cesarean section who were pregnant again,139 cases(success group)were succeed in transvaginal delivery,while 31 cases failed trial delivery,and transferred to cesarean section(failure group).The AOP of the successful group was significantly larger than that of the failed group when the cervix was opened to 4 cm,and the HPD was significantly shorter than that of the failure group(P＜0.05).The AOP change rate and the change rate of HPD of the suc-cessful group were significantly higher than that of the failed group when the cervix dilated to 4 cm and at 1 hour(P＜0.05).The AUC of AOP and HPD in predicting the outcome of vaginal trial de-livery of scar uterus after cesarean section were 0.846 and 0.812 respectively,and AUC predicted jointly by AOP and HPD showed no significant differences compared with AUC predicted separately(P＞0.05).The AUC of the change rate of AOP and HPD in predicting the outcome of vaginal trial delivery of scarred uterus after cesarean section was 0.899 and 0.852 respectively,and the com-bined prediction of AOP change rate and HPD change rate had a higher AUC value than the AUC predicted separately.Its AUC value was higher than that of AOP combined with HPD(P＜0.05).Conclusion The AOP,HPD and their change rates when the uterine orifice expands to 4 cm in the active phase of the first stage of labor have predictive value for the outcome of vaginal trial produc-tion of scarred uterus after cesarean section.

Objective To investigate the predictive value of labor progress angle(AOP),fetal head descent distance(HPD)and their change rates in the outcome of vaginal trial of cesarean scar uterus.Methods A total of 170 pregnant women who underwent vaginal trial production of scar ute-rus after cesarean section were selected as study subjects,and were divided into successful group and failed group based on the trial production outcomes.Advanced oxidation processes(AOP)and head-perineum distance(HPD)were measured by ultrasound during the active phase of the first stage of labor when the cervix dilated to 4 cm and at 1 hour after the cervix dilated to 4 cm,respectively.The AOP change rate and HPD change rate after 1 hour of progress were calculated.The receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of AOP,HPD and their change rates in the outcome of vaginal trial production of scar uterus after cesarean section.Delong test was used to compare the differences in area under curves(AUCs).Results Among 170 pregnant women with scarred uterus after cesarean section who were pregnant again,139 cases(success group)were succeed in transvaginal delivery,while 31 cases failed trial delivery,and transferred to cesarean section(failure group).The AOP of the successful group was significantly larger than that of the failed group when the cervix was opened to 4 cm,and the HPD was significantly shorter than that of the failure group(P＜0.05).The AOP change rate and the change rate of HPD of the suc-cessful group were significantly higher than that of the failed group when the cervix dilated to 4 cm and at 1 hour(P＜0.05).The AUC of AOP and HPD in predicting the outcome of vaginal trial de-livery of scar uterus after cesarean section were 0.846 and 0.812 respectively,and AUC predicted jointly by AOP and HPD showed no significant differences compared with AUC predicted separately(P＞0.05).The AUC of the change rate of AOP and HPD in predicting the outcome of vaginal trial delivery of scarred uterus after cesarean section was 0.899 and 0.852 respectively,and the com-bined prediction of AOP change rate and HPD change rate had a higher AUC value than the AUC predicted separately.Its AUC value was higher than that of AOP combined with HPD(P＜0.05).Conclusion The AOP,HPD and their change rates when the uterine orifice expands to 4 cm in the active phase of the first stage of labor have predictive value for the outcome of vaginal trial produc-tion of scarred uterus after cesarean section.

The research on type 2 diabetes mellitus(T2DM)remission has gone through more than 60 years and has made significant achievements in remission strategies,mechanisms and predictive indicators.However,there are significant differences in the definition and criterion of T2DM remission.This article analyzes,compares and accurately interprets the definition and criterion of T2DM remission,aiming to provide a basis for further research.