Objective To evaluate the clinical efficacy,safety and prognosis of patients with renal pelvis carcinoma and upper ureteral carcinoma treated by retroperitoneal laparoscopic radical nephroureterectomy.Whether there is a significant difference in the clinical efficacy,safety and prognosis of two different methods of ureteral terminal treatment(lower abdominal small incision and transurethral resection).Methods Analysis of the data from 108 patients with renal pelvis carcinoma or upper ureteral carcinoma,treated by nephroureterectomy at the first affiliated Hospital of Xinjiang Medical University from January 2012 to December 2022 was conducted.according to the different treatment of the end of the ureter,the patients were divided into two groups:lower abdominal small incision group(open group,n=58)and transurethral resection group(transurethral resection group,n=50).Patients in the open group underwent a retroperitoneal laparoscopic nephroureterectomy,along with a lower abdominal small incision ureterectomy,and those in the urethra group underwent a retroperitoneal laparoscopic nephroureterectomy and transurethral resection of the ureter.To gain a better understanding of the clinical data of the two groups,including basic data,operation time,intraoperative blood loss,postoperative hospital stay,and postoperative outcomes,a collection of data was made.recurrence,recurrence location and complications,a conclusion was drawn by statistical analysis.Results The open group's average operation time was(171±54)min,while the urethra group's was(141±37)min.However,no significant difference in intraoperative blood loss,postoperative hospital stay,recurrence rate,or postoperative complications was observed between the two groups.Conclusion Consequently,it is concluded that both methods of ureteral terminal treatment for renal pelvis and upper ureteral carcinoma are safe and dependable,with the transurethral resection operation time being shorter.at the same time,it did not increase the risk of postoperative recurrence and complications,intraoperative blood loss and postoperative hospital stay.