Objective To explore the curative effect of endoscopic simple maxillary ostium enlargement in the treatment of non-invasive mycosis of maxillary sinus. Methods Clinical data of 16 cases of noninvasive mycosis of maxillary sinus were analyzed retrospectively. Results The operation time was 30～120 minutes, with a mean of 60 minutes. No operative complications occurred. The hospital stay was 5～7 days, with a mean of 6 days. Histopathological examination found hyphae and spores in 16 cases, and a positive culture of Aspergillus was observed in 9 cases. Postoperative follow-up for 3～24 months (mean, 18 months) in 16 cases revealed free of symptoms in 14 cases, in which the endoscopic examination showed unobstructed ostium and normal sinusal mucosa, and recurrence in 2 cases, who underwent repeated enlargement of ostium and were re-followed for 6 and 13 months, respectively, without recurrence. Conclusions Nasal endoscopic simple maxillary ostium enlargement in the treatment of non-invasive mycosis of maxillary sinus is a radical and minimally invasive technique, but particular attention must be directed to managing the maxillary ostium.

Objective To investigate the curative effect of tube placement and drug irrigation in the auditory tube under nasoscope in the treatment of secretory otitis media(SOM). Methods Under the visualization of a 30? nasoscope,an epidural guiding tube was placed through the pharyngeal opening of the auditory tube into the tympanic cavity for drug irrigation in 50 cases of secretory otitis media(50 ears).Results Follow-up observations for 6~24 months showed 26 cases of cure(52%),19 cases of improvement(38%),and 5 cases of no effect(10%),the total effective rate being 90%. Conclusions This procedure has advantages of simplicity of performance,unaffected drum membrane,high safety,no pain,and satisfactory outcomes,being an effective treatment option for improving the function of the auditory tube and hearing ability in patients with secretory otitis media.

Objective To investigate advantages of sep to plasty under nasal endoscope. Methods Septoplasty was carried out under nasal endoscope in 50 cases, including 6 cases of upper or posterior n asal septum deviation. Results The operation was completed on one session in all the 50 cases, with the deviated nasal septum being entirely c orrected. The operation time was 30~72 min (mean, 48 min). Follow-up surveys for 6~9 months (mean, 7.1 months) indicated a complete cure in 45 cases (90%) and a n improvement in 5 cases (10%). No septal hematoma, abscess, perforation, nasal cavity adhesion, or bridge collapse were encountered. Conclusions Nasal endoscopic septoplasty has advantages of short operation time, few bl ood loss, mild pain, little complications, and the possibility of nasal sinus co -operation. This technique may fully replace the traditional submucous resection .

Objective:To explore CCR7 expression in splenic dendritic cells and its role in migration and activity of splenic dendritic cells in multiple organ dysfunction syndrome (MODS) in mice.Methods:The MODS model of mice was reproduced by Zymosan injection into peritoneal cavity.The mice were randomly divided into groups of normal,3-6 hours,24-48 hours and 10-12 days post zymosan injection.CD11c and CD205 were analysed by immunohistochemistry;The expression of CD86 and CCR7 of DCs were studied by the flow cytometry analysis.Results:In normal mice,many DC were found at the margin between the red and white pulp.In the 3-6 h and 24-48 h groups,CD86 and CCR7 were strongly up-regulated in the DC,and they distributed in T cells areas.In the 10-12 d group,DC distributed at the margin by the immature form.Conclusion:The CCR7 expression level of DC has close correlations with the migration of DC,CCR7 can be used to evaluate the migration and functional activity of DC in MODS.

Objective: To investigate the efficacy and safety of magnesium aluminium carbonate, lansoprazole, amoxicillin and furazolidone in the treatment of Helicobacter pylori-related gastric ulcer. Methods: From March 2016 to December 2017, 120 patients with HP related gastric ulcer who met the inclusion criteria were enrolled in the digestive department of Linxi Hospital of Kailuan general hospital.They were divided into observation group and control group with random number table method, 60 cases in each group.The control group was given lansoprazole+ amoxicillin+ furazolidone triple therapy.On this basis, the observation group was added with magnesium aluminum carbonate.The clinical efficacy, clearance rate of Helicobacter pylori, the level of VEGF and EGF in gastric juice were compared between the two groups. Results: The total clinical effective rate of the observation group was 95.0% (57/60), which was significantly higher than that of the control group (83.3%) (50/60). The difference between the two groups was statistically significant (χ²=4.23, P<0.05). The comprehensive symptom scores of the two groups decreased significantly with the treatment time (observation group: before treatment(9.6±2.2), treatment 2 weeks (5.5±1.5), treatment 4 weeks (4.3±1.2), treatment 6 weeks (3.1±0.8), control group (9.4±2.5), treatment 2 weeks (7.2±1.3), treatment 4 weeks (6.6±1.4), treatment 6 weeks (4.5±1.0)), and observation group syndrome scores There was significant difference between the two groups (F_inter-group=23.54, P_inter-group<0.05; F_intra-group=87.62, P_intra-group<0.05; F_interaction=8.47, P_interaction<0.05). After treatment, VEGF level in gastric juice of the two groups increased significantly after treatment.In the observation group( (429.4±128.5) pg/ml )was significantly higher than that in the control group( (380.3±137.2) pg/ml, t=2.02, P<0.05). The EGF level in gastric juice of the two groups increased significantly after treatment.In the observation group( (658.1±164.0) pg/ml )was significantly higher than that in the control group ((583.5±135.1) pg/ml, t=2.72, P<0.05). The incidence of adverse reactions was 6.7% (4/60) in the observation group and 8.3% (5/60) in the control group.There was no significant difference (χ²=0.12, P>0.05). Conclusion The treatment of Helicobacter pylori related gastric ulcer with the combination of aluminum carbonate, lansoprazole, amoxicillin and furazolidone can obviously improve the clinical symptoms and promote the regeneration of ulcer mucosa.