OBJECTIVETo investigate whether the effect of Biminne on allergic rhinitis (AR) was through improving vascular permeability of nasal mucosa.

METHODSRat's model in Biminne-treated group and model group was induced by intraperitoneal injection of ovalbumin (OVA) and aluminum hydroxide gel suspension Biminne-treated rats were orally given Biminne suspension from the 8th day to the 17th day. On the 18th day, Evan's blue dye (EBD) in the nasal perfusate was detected to assess the vascular permeability.

RESULTSEBD concentration was higher in the model rats than that in the normal rats, and lower in the Biminne-treated rats than that in the model rats (both P < 0.01).

CONCLUSIONBiminne could improve vascular permeability of nasal mucosa in sensitized rats, which may be the mechanism of its clinical effect on AR.

Animals ; Anti-Allergic Agents ; pharmacology ; Capillary Permeability ; drug effects ; Drugs, Chinese Herbal ; pharmacology ; Injections, Intraperitoneal ; Male ; Nasal Mucosa ; blood supply ; Ovalbumin ; administration & dosage ; toxicity ; Rats ; Rats, Inbred BN ; Rhinitis, Allergic, Perennial ; chemically induced ; physiopathology