Cardia ; pathology ; surgery ; China ; epidemiology ; Esophageal Neoplasms ; diagnosis ; epidemiology ; surgery ; Esophagectomy ; Esophagoscopy ; Gastroscopy ; Humans ; Mass Screening ; Minimally Invasive Surgical Procedures ; Precancerous Conditions ; diagnosis ; surgery ; Stomach Neoplasms ; diagnosis ; epidemiology ; surgery

Animals ; Carcinogens ; toxicity ; Female ; Lung Neoplasms ; chemically induced ; pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Sensitivity and Specificity ; Urethane ; toxicity

Objective To explore the associations between microsatellites in gonadal receptor genes and dysfunctional attitudes in adolescent with major depressive disorder(MDD).Methods Polymerase chain reaction(PCR),capillary electrophoresis and genetic scanning were performed in testing the length of microsatellites in first-onset adolescent depressive patients.Dysfunctional attitudes scale(DAS) was used in rating the dysfunctional cognition of adolescent depressive sample.These results were tested by correlative analysis and comparison analysis.Results 1.There existed significantly negative correlation between microsatellite′s length in estrogen receptor ?(ER?) gene and total score of DAS in female adolescent patients with first-onset depressive disorder.2.DAS′ total score of shorter alleles′ group was significantly higher than that of longer alleles′ group on female′ estrogen receptor ?(ER?) Gene.Conclusion The microsatellite′s length of ER? and ER? gene may have associations with dysfunctional attitudes of female adolescent with MDD.

OBJECTIVETo study the effects of various planting densities on dynamic growth and root yield of Isatis indigotica.

METHODThe planting samples were collected to measure the growth period of each organ.

RESULT AND CONCLUSIONUnder different planting densities, both main root length and breadth exhibited a trend of "fast-slow" by stages. However, the number of individual plant leaves were showed a trend of "slow-fast" on growth period. Meanwhile, the leaf length and breadth were exhibited a trend of "increase-decrease". The increase of dry leaf, dry root and whole plant dry matter was faster during the period of 65-76 days after seeding. The differences of root and leaf yields under various densities were significant. Planting densities has a great effect on yield of root. It must be shown that there was a positive development between the individual plant and colony. According to the dry matter of root and leaf, treatment B (i.e., 7 cm x 25 cm) was good choice.

Biomass ; Isatis ; growth & development ; Plant Roots ; growth & development

OBJECTIVETo study the genetic diversity of pollen grains morphologies of Pinellia ternata in different populations and supply palynological evidences for further research.

METHODPollen exine ultrastructure were compared for 18 populations growing under in the same environment by means of scanning electron microscope(SEM).

RESULT AND CONCLUSIONBig difference was found in pollen size among populations of P. ternata: the mean value of seventeen populations of P. ternata with bulbils was 17.42 microm x 14.86 microm, the biggest of populations originated from Jangyan city is 20.43 micromx 18.16 microm, but the least originated from Peixian County is only 15.23 microm x 12.82 microm; the size of populations without bulbils originated from Linguo Temple side was only 13.23 microm x 11.98 microm and far less than of all populations with bulbils. The pollen surface of all populations sticks out with spines, varying in size and density, the base and top part of spinules was different among populations. The pollen grains patterns of germination apertures of P. ternata was likely to have colpate cover.

China ; Genetic Variation ; Pinellia ; genetics ; ultrastructure ; Plants, Medicinal ; genetics ; ultrastructure ; Pollen ; genetics ; ultrastructure

Accidents, Traffic ; Child ; Humans ; Risk Factors

OBJECTIVEThe aim of this study was to observe the association between the occurrence of esophageal cancer lesions and esophageal mucosa fold (white ridges), and further identify where is the initial origin of esophageal cancer lesions in the esophagus mucosa.

METHODSThis was a cohort study which recruited 551 subjects underwent endoscopic examination in a high risk area of esophageal cancer in Linxian, Henan Province in 1987. 339 subjects with esophageal white ridges, and with red area or erosion lesion at the surface of the white ridges, was studied as exposure group. Other 212 subjects whose esophagus had no white ridges and pathological diagnosis was negative, was studied as control group. The endpoint was occurrence of pathologically confirmed esophageal cancer. After a 15-year follow-up, the results were compared between two groups.

RESULTSAmong the 551 subjects, there were 339 cases with esophageal mucosal white ridges in the exposure group. During the period of 15 year follow-up, the incidence of esophageal cancer was 11.8% (9/76) in 76 case with simple mucosal white ridges, 33.5% (88/263) in 263 subjects with white ridges and red area, or erosions on the surface of white ridge. While only 8.0% of subjects (17/212) developed esophageal cancer after the 15-year follow up in the control group. There was a significant difference between the two groups (P < 0.001).

CONCLUSIONEsophageal mucosal white ridge, especially white ridge with red area or erosions is closely associated with subsequent esophageal cancer occurrence in the esophageal cancer high risk area in China. It is suggested that esophageal mucosa with white ridge may be the initial origin of esophageal cancer. Further investigations focused on this spot are required.

Adult ; Aged ; Carcinoma, Squamous Cell ; epidemiology ; pathology ; China ; epidemiology ; Cohort Studies ; Esophageal Neoplasms ; epidemiology ; pathology ; Esophagoscopy ; Esophagus ; pathology ; Female ; Follow-Up Studies ; Humans ; Hyperplasia ; pathology ; Incidence ; Male ; Middle Aged ; Mouth Mucosa ; pathology ; Precancerous Conditions ; epidemiology ; pathology ; Prospective Studies

Aneurysm, Dissecting/surgery* ; Aorta, Thoracic/surgery* ; Aortic Aneurysm, Thoracic/surgery* ; Blood Vessel Prosthesis Implantation ; China ; Endovascular Procedures ; Humans ; Retrospective Studies ; Treatment Outcome

To investigate the production status and the safety influence factors of wolfberry in China. We investigated the detailed factors which affect the quality safe of wolfberry in the periods of July-August 2013 and July-September 2009. The factors include fertilizing patterns, the used pesticide and preliminary process wolfberry. The factors were discussed according to the results of investigation, and suggestions were proposed for the management and production departments of wolfberry.
China ; Fertilizers ; analysis ; Lycium ; chemistry ; growth & development ; microbiology ; parasitology ; Pest Control ; Plant Diseases ; microbiology ; parasitology ; prevention & control

BACKGROUNDGlycoprotein non-metastatic melanoma protein B (GPNMB) plays an important role in the pathogenesis of inflammatory and malignant diseases. We investigated the expression of GPNMB in benign and malignant skin diseases.

METHODSTissue microarray was performed in the skin tissues of 102 cases including malignant melanoma (MM), squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and benign dermatosis. The expression of GPNMB in the tissues was detected by immunohistochemistry. Twenty cases of normal skin and adjacent neoplastic normal skin tissues were selected as controls.

RESULTSGPNMB was positively stained in skin malignancies (38/50, 76%), which was significantly higher than that in the control and the benign skin tissues (P = 0.001 and < 0.001 respectively). GPNMB was positively stained in MM (13/15, 87%) and SCC (16/20, 80%) (P < 0.001). Significant higher expression of GPNMB was observed in patients aged ≥ 65 years than those less than 65 years (n = 11 and n = 9 respectively, P = 0.027). No significant difference of the expression rates was observed between normal control and BCC; however, stronger intensity was detected in the latter. Negative or weak expression was observed in the controls.

CONCLUSIONOver-expression of GPNMB correlated strongly and might play an important role in the pathogenesis of MM and SCC.

Adolescent ; Adult ; Aged ; Carcinoma, Basal Cell ; metabolism ; Carcinoma, Squamous Cell ; metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Melanoma ; metabolism ; Membrane Glycoproteins ; metabolism ; Middle Aged ; Skin ; metabolism ; pathology ; Skin Diseases ; metabolism ; Skin Neoplasms ; metabolism ; Tissue Array Analysis ; methods ; Young Adult