Epithelial-mesenchymal transition (EMT) is an important biological process in embryonic development and tumori-genesis. In this process, epithelial tumor cells can obtain mesenchymal phenotypes and promote tumor invasion and metastasis. EMT is controlled by multiple transcription factors, signal pathways, and microRNAs. EMT and cancer stem cells are closely related. EMT also promotes the self-renewal ability of tumor cells and the overexpression of EMT-related markers in tumor cells with stemness. Some mi-croRNAs can control EMT process and stemness. In this study, recent developments on EMT and cancer stem cells in tumor metastasis were summarized to provide new insights into target therapy of tumor metastasis and recurrence.

BACKGROUND:Fibrin glue can function to close the wound tissue, reduce leakage, stop bleeding, promote wound healing and prevent adhesion.
OBJECTIVE:To systematicaly review the application of fibrin glue in thyroid surgery.
METHODS:We searched China Journal Net database, Wanfang database, VIP database, Chinese Biomedical Database Online to retrieve clinical randomized controled trials related to fibrin glue applied in thyroid surgery from January 2000 to April 2013. Included studies were analyzed using Rev Man 5.2 statistical software for Meta-analysis.
RESULTS AND CONCLUSION:A total of six studies including 797 cases were enroled in result analysis. Meta-analysis showed that the drainage volume at postoperative day 1 and total postoperative drainage volume were higher in the fibrin glue group than the control group (without fibrin glue) [odds ratio=-27.36, 95% confidence interval (-33.86,-20.87),P < 0.00001; weighted mean difference=-38.73, 95% confidence interval (-44.78,-32.67),P < 0.000 01]. The suture removal time was shorter in the fibrin glue group than the control group [odds ratio=-2.00, 95% confidence interval (-2.17,-1.83),P < 0.000 01]. No significant difference was found in the postoperative 3-day fever incidence [odds ratio=1.53, 95% confidence interval (0.59,3.96),P=0.38], wound infection [odds ratio=0.86, 95% confidence interval (0.12, 6.15),P=0.88], and postoperative hematoma [odds ratio=0.86, 95% confidence interval (0.21, 3.48),P=0.83] between the two groups. These findings indicate that fibrin glue used in thyroid surgery can significantly reduce drainage by non-increasing postoperative complications.

Occupational Health

Accidents, Occupational ; Adult ; Emergency Nursing ; Emergency Treatment ; Humans ; Male ; Poisoning ; nursing ; therapy ; Trimethyltin Compounds ; poisoning ; Young Adult

Objective To clarify the differential diagnosis between limb-girdle muscular dystrophy type 2B (LGMD2B) and polymyositis (PM). Methods Analyzed the character of clinical, histochemical and immunohistochemical pathologic with biopsied skeletal muscle in 5 patients with LGMD2B and the relationship with PM. Results Both LGMD2B and PM showed the muscle weakness in proximal limbs and elevated creatinkinase level and electromyogram showed myogenic damage. Histochemical stains: it was similar to PM, that was the muscle fibers degenerating, regenerating and necrotic and the infiltrating inflammatory cells in different extent in 5 patients. Immunohistoehemical stains: anfi-Dysferlin monoelonal antibody showed that Dysferlin was deficient on sarcolemma in LGMD2B, but it was normal in PM. Conclusions It is resemble on the clinical and histoehemieal pathologic characters in both LGMD2B and PM. It is key to antidiastole LGMD2B and PM by the immunohistochemieal stain of anti-Dysferlin monoelonal antibody.

Angina pectoris is an important event in coronary heart disease.Many researches are conducted on the risk factors and risk stratification of the problem,so as to classify the patients into different risk groups,properly predict their prognosis,take the most effective therapeutic measures and achieve the best results with the least risks and expenses.

Objective To investigate the change of serum C-reactive protein(CRP) levels in patients with acute cerebral infarction(ACI) and ACI with multiple organ dysfunction syndrome(MODS), and the relationship between serum CRP levels and incidence of MODS.Methods The serum CRP levels of 30 normal healthy people and 82 patients with ACI were detected by immune transmission turbidity method. The data from the patients with lacunar cerebral infarction(LCI), acute simple cerebral infarction(PACI) and ACI with MODS(ACI+MODS) were compared.Results The levels of serum CRP in patients with ACI significantly increased compared with the controls( P

With improvement in stent designs, the practice of direct stenting (DS) without balloon predilation has become more widespread. DS may allow partial retention of endothelium within treated arteries, and associate with decreased utilization of contrast agent, number of catheter, exposure of X-ray,and expense. This paper evaluate the experiment base, principle, indication, contraindication, skills, complications as well as the result of acute and chronic follow up of DS.

This experiment has proved that bolbostemmosaponin and its constituents A and D have relatively powerful spermatocidal effects. They can kill all spermatozoa in a moment at the concentrations of 0.04%, 0.04% and 0.03% respectively. These spermatocidal agents mainly distroy the biomembrane system of sperm. Using the fixed gelatin membrane technique proved that all of them can strongly inhibit tne activity of a single sperm acrosin at the concentration of 0.05%.

Taxonomy of genus Rhodococcus has been changing since it was set up by Zopf in 1891 The classification of the genus has been changed dramatically in recent years, with the species being reclassified and new species described Th e changing of taxonomy is mainly on the methods' altering from old morphological to modern polyphasic taxonomy Additionally, there has been increased interest i n rhodococcus for its abilities to degrade a range of environmental pollutants a nd to transform or synthesize compounds with possible usefull application