Acupuncture Therapy ; Adult ; Alcoholism ; therapy ; Humans ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Peripheral Nervous System Diseases ; therapy

Unfolded protein response(UPR) is a protective response in cell endoplasmic reticulum(ER) under stress condition.Three ER transmembrane proteins,IRE1,PERK,and ATF6,coordinately regulate the UPR function in mammalian cells through their signaling pathways.In addition,some proteins and transcription factors during the UPR can provide negative and positive feedback loops to maintain the normal function of ER.UPR can trigger cell death or apoptosis and eventually cause related diseases if the ER stress persists.Several key mediators of UPR are candidates for therapeutic targets in many studies.Up to now progress has been made in the area,which provides new ideas for clinical practice and holds a great potential for future application.

Objective To study the effects of different factors influencing the quality of life of elderly esophageal cancer patients who returned to the community after surgery.Methods A total of 216 elderly esophageal cancer patients with complete clinical data who had returned to the community after surgery were followed up by questionnaires,including the European Organization for Research and Treatment of Cancer Quality of Life rating (EORTC QLQ-C30) and esophageal cancer supplementary (QLQ-OES18) scales.Results The overall quality of life score of the patients was (35.2±22.1),which was lower than that in the Norwegian norm data.Scores for cognitive function,constipation,diarrhea,shortness of breath and loss of appetite were similar to those in the norm data.Scores for physical function,emotional function,role function and were lower than those in the norm data,while scores for pain,fatigue,nausea and vomiting,sleeplessness and were higher than those in the norm data.The overall quality of life score was higher in male patients than in female patients (F =5.12,P=0.029),in patients with spouses than in those without spouses (F=5.61,P=0.016),and in patients without complications than in those with complications (F=5.48,P=0.002).The overall quality of life was higher with longer survival times after surgery (F=3.68,P=0.003).No significant difference in the overall quality of life score was found between different age-groups (F=4.23,P=0.212).Conclusions The overall postoperative life quality is poor in community elderly patients with esophageal carcinoma.Gender,marital status,postoperative survival time,and complications are among the factors influencing postoperative quality of life of community elderly patients with esophageal carcinoma.

Objective To observe the clinical effect of Xisui Huangu Formula combined with technetium [99Tc] methylenediphosphonate injection in the treatment of avascular necrosis of femoral head (ANFH). Methods A total of 73 patients were randomly divided into treatment group (37 cases) and control group (36 cases). The control group was given conventional western medicine treatment, while the treatment group was given Xisui Huangu Formula on the basis of conventional western medicine treatment. Clinical symptoms and joint function of the two groups were observed before and after treatment, and the clinical effects were compared. Results In the treatment group, 17 cases were cured, 17 cases improved, 3 cases were unrecovered, and the effective rate was 91.89%. In the control group, 4 cases were cured, 25 cases improved, 7 cases were unrecovered, and the effective rate was 80.56%. The difference was statistically significant between the two groups (P<0.05). Improvement of joint pain, lameness, dysfunction, and joint function in the treatment group were better than those in the control group (P<0.05). Conclusion Xisui Huangu Formula can significantly improve clinical symptoms of ANFH. Integrated traditional Chinese and Western medicine therapy is helpful to alleviate ANFH disease progression.

This paper expounded the development situation of doctor -patient communication software , from two aspects of the server and the client introduces the main functions of the 3D orthopaedic doctor -patient commu-nication software , discussed emphatically the main role , including: improving the efficiency of doctor -patient communication;improving the quality of medical services;improving the patients′satisfaction degree .

Drug research involves scientific discovery, technological inventions and product development. This multiple dimensional effort embodies both high risk and high reward and is considered one of the most complicated human activities. Prior to the initiation of a program, an in-depth analysis of "what to do" and "how to do it" must be conducted. On the macro level, market prospects, capital required, risk assessment, necessary human resources, etc. need to be evaluated critically. For execution, drug candidates need to be optimized in multiple properties such as potency, selectivity, pharmacokinetics, safety, formulation, etc., all with the constraint of finite amount of time and resources, to maximize the probability of success in clinical development. Drug discovery is enormously complicated, both in terms of technological innovation and organizing capital and other resources. A deep understanding of the complexity of drug research and our competitive edge is critical for success. Our unique government-enterprise-academia system represents a distinct advantage. As a new player, we have not heavily invested in any particular discovery paradigm, which allows us to select the optimal approach with little organizational burden. Virtue R&D model using CROs has gained momentum lately and China is a global leader in CRO market. Essentially all technological support for drug discovery can be found in China, which greatly enables domestic R&D efforts. The information technology revolution ensures the globalization of drug discovery knowledge, which has bridged much of the gap between China and the developed countries. The blockbuster model and the target-centric drug discovery paradigm have overlooked the research in several important fields such as injectable drugs, orphan drugs, and following high quality therapeutic leads, etc. Prejudice against covalent ligands, prodrugs, nondrug-like ligands can also be taken advantage of to find novel medicines. This article will discuss the current challenges and future opportunities for drug innovation in China.

AIM: To verify the neuroprotective effect and optimize the therapeutic dose and time window of picroside Ⅱon cerebral ischemic injury in rats .METHODS:The forebrain ischemia model was established by the method of bilateral common carotid artery occlusion ( BCCAO ) .The successful model rats were randomly divided into 16 groups according to orthogonal design and treated by intraperitoneal injection of picroside Ⅱat different ischemic time poinis and different doses .The changes of the nerve fiber myelin were observed by fast green staining .The immunohistochemical assay and Western blotting were used to quantitatively and qualitatively determine the expression of myelin basic protein (MBP). The mRNA level of MBP in the brain tissues was tested by reverse transcription polymerase chain reaction (RT-PCR).RE-SULTS:Picroside Ⅱ increased the expression of MBP and decreased demyelination after cerebral ischemic injury .The best therapeutic time window and dose were:(1) ischemia for 2.0 h with picrosideⅡat dose of 10 mg/kg according to the results of fast green staining;(2) ischemia for 2.0 h with the dose of 10 mg/kg according to the results of immunohisto-chemical assay;(3) ischemia for 2.0 h with the dose of 10 mg/kg according to the analysis of Western blotting;(4) is-chemia for 1.5 h with the dose of 20 mg/kg according to the detection of RT-PCR.CONCLUSION:Given the principle of the lowest therapeutic dose with the longest time window , the optimized therapeutic dose and time window for rat cerebral ischemic injury is intraperitoneal injection of picroside Ⅱat the doses of 10~20 mg/kg and the time window of ischemia for 1.5~2.0 h.

The pathogenesis of migraine is not fully understood as yet. Recently, with the development of ultrasonography, some stud-ies indicated that the prevalence of right-to-left shunt (RLS) seemed to be higher in migraine, especially in migraine with aura. The progress in the relationship between migraine and RLS was reviewed.

Objective To investigate the easement degree of pain after the treatment of low back pain patients in 6 months after the operation.Methods To treat lumbar degenerative osteoarthritis (21cases),lumbar disc herniation(31 cases),Lumbar spinal stenosis assompanied with lumbar disc herniation(1 cases) with percutaneous radiofrequency-ablation,compare the JOA,VAS,Oswestry score of the patients before and at the just after operation,2 weeks,6weeks,3 months,6 months after operation.Results The JOA score of patients after operation rise obviously than that of patients before operation,and VAS and Oswestry score reduce obviously,they all have statiscal significance(P ＜ 0.05).Conclusion The pain of patients who suffered from discogenic low back pain,lumbar disc herniation is relieved by percutaneous radiofrequency-ablation,the quality of patients'life is heightened,all of above indicate that the treatment is an effective method for discogenic low back pain,lumber disc herniation.