Pharmacometabonomics, as an emerging branch of system biology, has been increasingly used in personalized medicine and showed broad prospects. By means of metabonomics, the complicated and detailed metabolic profile of the patient is described, thus providing more detailed description of the disease phenotype. With this understanding, response of different individuals to the drugs are predicted or evaluated through inherent genetic information of the individual combined with the environmental factors. As a result, appropriate drugs and dosage are chosen, which greatly promotes the realization of the individualized therapy goals. This article describes the emerging field of pharmacometabonomics, and the research results of personalized medicine based on the pharmacometabonomics in recent years are reviewed in detail.
Humans ; Metabolome ; Metabolomics ; Pharmacogenetics ; Precision Medicine ; methods

ObjectiveTo observe the rabbit cardiac siz e and cardiac function change before and after bone-marrow stem transplanting(BMST) by echocardiography.MethodsThirty-four rabbits were divided into 3 groups randomly: group control, group myocardial infarction(MI) and group BMST. The left anterior coronary artery in group MI and group BMST were ligated to produce the myocardial infarction model and injected bone-marrow stem cell to the infracted area in the later group. The size and the systolic function of the heart were measured before and after infarction and transplantation. The left ventricular systolic pressure (LVSP) and the end-diastolic pressure(LVEDP) were also measured in the 3 groups at the end of experiment. ResultsThe left ventricle diameter of group BMST was smaller than that of the group MI, and the ventricular function increased, and almost reached the normal level. And more, LVSP increased and LVEDP decreased statistically in the group BMST. ConclusionsBone-marrow stem transplantation can release the enlargement of left ventricle and improve cardiac function after myocardial infarction.

Humans ; Hypertension, Pulmonary ; etiology ; Male ; Middle Aged ; POEMS Syndrome ; complications

Agglutinins ; immunology ; Anemia, Hemolytic, Autoimmune ; Humans ; Immunoglobulin G ; Infant, Newborn

Objective To investigate the damage control surgery(DCS)in the treatment of severe abdominal trauma and the clinical value of learning from experience.Method Forty-severl cases of severe abdominal trauma patients treated with DCS were analyzed retrospectively.Results Forty-one cases (87.23%)were cured,liver abscess after re-operation was 3 cases(6.38%),intestinal fistula,biliary fistula,pancreatic fistula was 1 case(each 2.13%),they were cured by conservative treatment,6 cases(12.77%)were died,the causes of death were nothing to do with the surgery.Conclusion For patients with severe abdominal trauma actively adopt DCS,is safe and effective,with clinical value.

The authors described two cases with primitive trigeminal artery. Case 1 was a 32-year-old woman who suffered dizziness and a serious pulsatile intracranial bruit on the left ear, and sometimes associated with pulsatile intracranial bearing-pain on the left temporal side six months before she was admitted to the hospital. She also suffered from obvious diplopia on left lateral gaze for the last 5 months. She had suffered no recent trauma. Magnetic resonance imaging(MRI) demonstrated a suspected intracranial aneurysm located in left cavernous sinus. Digital subtraction angiography (DSA) was performed and a primitive trigeminal artery-cavernous sinus fistula in left side was found. Intraluminal occlusion of the fistula was successfully performed immediately after angiography using 6 Guglielmi detachable coils (GDC), and the patient was cured finally. Case 2 was a 28-year-old woman who suffered a serious intermittent cephalodynia associated with soreness on the left body two years before she was admitted to the hospital. She had suffered no recent trauma. Magnetic resonance angiography(MRA) demonstrated a suspected intracavernous aneurysm of the right internal carotid artery, Digital subtraction angiography (DSA) was performed. Right internal carotid angiography showed a primitive trigeminal artery (PTA) run between the cavernous segment of the internal carotid artery and the distal portion of the basilar artery. On initiation of PTA of R-ICA a small wide-necked saccular aneurysm was incidentally visualized. The aneurysm was successfully embolized after angiography using 2 Stent (Neuroform, 4.5mmm × 20mmm)-assisted detachable coils (Matrix), the ICA and PTA were preserved, and the patient was cured finally.

Aim To establish a method to purify factor B in human sera. Methods A combination of euglobulin precipitation, ion-exchange chromatography,(NH4)2SO4 precipitation and affinity chromatography was used in the process of purification. Results Final product of 118.75 mg/L plasma factor B was obtained. By SDS-PAGE, thin layer scanner and activity assay,the purity reached 95％ , specific activity was 1.91× 109 IU/g, and the activity yield was 59.28％ . Conclusion This simple method with high yield can be used for laboratory research and large-scale preparation.

Objective To assess feasibility of three-dimensional(3D) reconstruction techniques and virtual gastroscopy of CT(CTVG)in diagnosing gastric tumors.Methods 22 cases doubted with gastric lesions were scaned by mutislice helic CT and reconstructed into CTVG and 3D images.The results were compared with fiberoptic gastroscopy(FG) and all of the cases were sure with gastric lesions and biopsied by gastroscopy or surgery operation.Results 22 patients was examinated successfully,and the lesions was proved by pathology of FG or operation.According to location and shape of lesions,there were more ulcer type(16) and more located at gastric antrum(14) in this specimen.Both CTVG and FG had one misdiagnosis respectively.Conclusion CTVG combined with 3D of MSCT is same sensitivity and specificity as FG.

Objective To study the value of clinical applications of multi-slice spiral CT(MSCT)3D reconstruction and MPR in knee joint traumatic fracture and the imaging technique of multi-slice spiral CT 3D.Methods 24 cases underwent MSCT and all data sets were done 3D and MPR in ADW 3.1 workstation.Results 3D reconstruction can indicated the site,direction of alignment,fracture degree,colapse,displacement length of trauma knee joint,MPR can viewed damage inside the bone.Conclusion 3D reconstruction and MPR has high application value in clinical diagnosis and choosing therapy methods.

Objective To study the correlation of measuring bone density for diagnosing osteoporosis between VQCT and DXA. Methods 50 patients were measured bone density coinstantaneous by DXA and VQCT. All of the data was saved in computer and analyzed by SPSS soft.Results According to WHO criterion 14 patients were osteoporosis by F-DXA and 9 by S-DXA,and 23 by VQCT.The percent was respective 28%,18% and 46%. The results of VQCT were significantly different from the results of F-DXA and S-DXA (?