Objective To study the change of serum procalcitonin(PCT) expression level and to investigate its clinical value for predicting the prognosis in the patients with severe acute pancreatitis (SAP) .Methods Totallay 48 inpatients with SAP in our hos‐pital from April 2012 to April 2014 were retrospectively analyzed .The PCT levels during different hospitalization period in the sur‐vial group and the death group were detected and analyzed .The scores of acute physiological and chronic health evaluation Ⅱ (A‐PACHE Ⅱ) were compared between these two groups .Results (1)The clinical characreristics of gender ,body temperature and WBC had no statistically significant differences beween the survival group and the death group (P>0 .05) ,but the PCT level had statistical differencet (P<0 .05) .(2)There was no statistically significant difference in the PCT level and APACHE Ⅱ score at ad‐mission between the two groups .In the later treatment process ,the PCT level and APACHE Ⅱ score in the survival group were progressively decreased ,while which in the death group were progressively inecreased (P<0 .05) .WT5HZ〗Conclusion PCT has an important clinical value in forcasting the prognosis of SAP .

Objective:To investigate the behavior profiles and correlates of subgroups of aggression and victimization in a rural children sample.Methods: 744 primary school children (10.96?1.32 years old) were investigated through peer nomination. Results: Classifications resulted in three subtypes, the aggressive-victims (54 boys, 16 girls), non-aggressive victims (20 boys, 18 girls), and 41 non-victimized aggressors (33 boys, 8 girls). MANOVA revealed significant differences among these subtypes and between genders on an array of social behaviors. Post hoc comparisons suggested that aggressive-victims had the lowest peer acceptance, highest peer rejection, and higher social withdrawal. Compared with normal groups, non-aggressive victims also showed more behavioral problems. Conclusion:The aggressive-victims have lowest peer relations and highest aggression and victimization, the non-aggressive victims have highest withdrawal and shyness.

Objective Metrological literature analysis of breast reconstruction from 1987 to 2008 in China,in order to illuminate the process of breast reconstruction's development and to predicts the mian tendency of breast reconstruction in the future.Methods Papers about breast reconstruction from 1987 to 2008 on Chinese Medical Current Content (CMCC) and Chinese Bio-medical Literature Database (CBMdisc) were Metrologically analyzed according to journal,institute,surgeon method,optimal time,content and so on.Results In all 247 collected,the first place in order of first jourual,institute,author,area,surgeon methods,optimal time were as follow:Chinese Journal of Aesthetic and Plastic Surgery (15 papers),China Chinese Academy of Medical Sciences and Peking Union Medical College (46 papers),Qi Fazhi (9 papers),Beijin(56 papers),latissimus dorsi perforator flap breast reconstruction,and transverse rectus abdom in is myocutaneous flap breast reconstruction,immediate reconstruction.Conclusions This paper which outlines some features of papers published in China on breast reconstruction in rencent 21 years provides a credible resource for further study.The immediate latissimus dorsi perforator flap breast reconstruction would be the main trend of it's further development.

Objective To discuss the value of holmium laser lithotripsy combined with choledochoscopy in the treatment of complicated common bile duct stones.Methods Under choledochoscopy,200 ?m fibre holmium laser lithotripsy of common bile duct stones was performed.The settings on the laser were 1.0 J and 10 Hz.The choledochoscope was used to access the common bile duct stones.The stones were fragmented and then extracted with irrigation or by using a basket. Results The stones were successfully removed in all the 17 cases.The duration of operation was 10~50 min(mean,20 min).Out of the 17 cases,there were 8 cases of primary closure of the common bile duct,6 cases of T-tube drainage, and 3 cases of stone removal via drainage passage.No bile duct bleeding or biliary leakage occurred after operation.Follow-up was conducted in 16 cases for 6~15 months(mean,10 months).B-ultrasonography or magnetic resonance cholangiopancreatography found no recurrent or residual stones,or bile duct stricture.Conclusions Holmium laser lithotripsy combined with choledochoscopy in the treatment of complicated common bile duct stones has advantages of minimal invasion,rapid recovery,satisfactory lithotripsy effects,simplicity of performance,and high reliability.

Cicatrix ; therapy ; Humans ; Laryngeal Diseases ; diagnosis ; therapy ; Vocal Cords ; pathology ; physiopathology

OBJECTIVE:To prepare glycyrrhetic acid derivatives-modified norcantharidin(NC)liposome(GDNL)and study its liver-targeting property.METHODS:Gal-GAOSt targeting molecules were synthesized to modify NC and prepare GDNL,with the parameters such as the entrapment efficiency and particle diameter,etc.investigated.Mice were enrolled to be injected with GDNL and NC water solution,respectively via vena caudalis followed by determination of NC concentration in different tissues to compute the targeting-index(TI)of GDNL in liver.RESULTS:The prepared GDNL had an entrapment efficiency of 56.29%,particle diameter of(210?20)nm and TI of 5.213 in liver.CONCLUSION:The prepared GDNL has high entrapment efficiency and remarkable liver-targeting property.

BACKGROUND:The immunological rejection between host and graft is the leading cause of organ
transplantation failure. The traditional immunosuppressive agents have been unable to meet the needs of clinical treatment. Antibody-drug conjugate, as a type of new drugs, may be hope for the treatment of immune rejection. OBJECTIVE:To comprehensively analyze the composition of antibody-drug conjugates, mechanism of action, clinical research progress as wel as the development trend.
METHODS:A computer-based online retrieval was performed to search papers in CNKI and PubMed database using the key words of ADCs, immunosuppressive agents, immunotoxins, organ transplantation, graft rejection in Chinese and English. Recently published or published in the prestigious journals were selected in the same field. After excluding objective-independent papers and repeated studies, 42 papers were included for further analysis. RESULTS AND CONCLUSION:Antibody-drug conjugates, as highly effective and lowly toxic immunosuppressant, have achieved a breakthrough in treatment of targeting tumor, while the role of it in anti-immune rejection is stil at the exploratory stage. For islet transplantation, novel antibody-drug conjugates are required to block CD8+T effector by CD103/E-Cadherin pathway, and wil probably serve as a potential drug intervention for al ograft rejection.

Objective To study the clinical value of vascular ultrasound examination in detection of carotid artery disease. Methods 53 cases of ischemic cerebrovascular disease who served as experimental group,tested 387 vessels; and used the same period 55 cases of healthy persons as control group, tested 394 blood vessels. Comparison of two blood flow parameters between groups with differences in plaque detection. Results The results of vascular ultrasound examination could detect the visual display and quantitative carotid artery lesions in the experimental group a significant thickening of carotid artery IMT,carotid artery plaque prevalence was significantly higher than control group (P ＜0.01). Conclusion Vascular ultrasound examination was an effective screening method to detect ischemic cerebrovascular disease.

0.05).5.The clinical symptoms of hMPV infection could not be discriminated from the infection of other common respiratory viruses.Conclusion The acute respiratory-tract infections among children of Xi'an city are associated with cough and fever are major clinical symptoms.

Objective To explore the anti-infection mechanism of carboxyamidotriazole (CAI) through studying the effects of CAI on the proliferation, apoptosis and degranulation of RBL-2H3 mass cells.Methods Compound 48/80 (C48/80) was used to induce the model of activation and degranulation in RBL-2H3 cells.The morphological change of cell degranulation was observed by neutral red staining.The release levels of histamine and β-hexosaminidase were measured by ELISA method and chromogenic assay, respectively.The cell activity was determined by CCK-8 method.And cell apoptosis was detected by Hoechst 33342 fluorescent staining.Results Compared with the control group, 10, 20, 40 μmol/L CAI inhibited C48/80-induced degranulation of RBL-2H3 cells in different degrees.CAI (20, 40 μmol/L) reduced the histamine release (P<0.01), and CAI (40 μmol/L) decreased the β-hexosaminidase release (P<0.01).In addition, the viability and apoptosis of RBL-2H3 cells were not affected at the concentrations of CAI used.Conclusions CAI can effectively inhibit the activation and degranulation of RBL-2H3 mast cells, and this effect is not through cytotoxicity.The anti-infection effect of CAI may partially due to the down-regulation of mast cell activity.