Objective To assess the efficacy of Danggui Yinzi versus western medicine for treating chronic urticaria.Methods CNKI,VIP,Wanfang data,EMbase,the citation databases of PubMed,web of science updated to August 2012 were electronically searched.Randomized controlled trials (RCTs) and Clinical controlled trial (CCTs) on Danggui Yinzi and western medicine for chronic urticaria were identified.The quality of included RCTs and CCTs was assessed,and the meta-analysis was conducted with Revman5.1 software.Funnel-plot was used to identify the publication bias and performed sensitivity analyses.Results 13 trails involving 1042 patients were included.The qualities of all these trails were relatively low.There was no trail set double blinding and allocation concealment.Meta-analysis indicated that compared with western medicine,the effective rate of Danggui Yinzi was superior to that of western medicine[OR=2.53,95％CI(1.92,3.34)].The funnel-plot demonstrated that there was publication bias.Conclusion The current evidence showed that Danggui Yinzi was superior to western medicine in efficacy,but we need more multicenter,randomized,double-blind trails to support it.

Objective To probe the mechanism of Warlker-256 cell apoptosis resulted from permanent and strong magnetic field. Method The amplification, rearrangement, deletion, transcription and expression of P53 were detected in 320 rats treated by magnetic field and 80 controls, using Dot Blot of DNA and RNA, Southern and Northern blot, and immunohistochemical technologies. Results P53 is wild type in Warlker-256 cells, no amplification, rearrangement and deletion were found in either magnetic treated group or control group. The transcription and expression of P53 is significantly enhanced in the treated group versus the control(P

Objective To observe the clinical therapeutic effect of acupuncture combined with acupoint injection in the treatment of post -stroke intractable hiccup.Methods 120 patients with post -stroke intractable hiccup were randomly divided into treatment group(60 cases)and control groups(60 cases)according to the digital table.The patients in the control group were treated with baclofen tablets and methloxetamine hydrochloride injection, and the patients in the treatment group were treated with acupuncture combined with acupoint injection therapy.The treating period was 1 week.The scores of hiccup symptoms,the total effective rate and side effect were recorded before and after the treatment in all patients.Results The scores of hiccup symptoms before treatment in the treatment group and the control group were (5.32 ±1.17)points and (5.25 ±0.65)points respectively,there was no statistically significant difference between the two groups(t =1.79,P =0.96).The scores of hiccup symptoms on the 1 day after treatment in the treatment group and the control group were (3.97 ±1.24)points and (3.85 ±1.02 )points respectively,there was no statistically significant difference between the two groups(t =1.93,P =0.48).The scores of hiccup symptoms on the 3 days after treatment in the treatment group and the control group were (2.80 ±0.73)points and (3.75 ±1.11)points respectively,there was significant difference between the two groups(t =2.66,P =0.00), that in the treatment group was lower than the control group.The scores of hiccup symptoms on the 5 days after treatment in the treatment group and the control group were (2.25 ±1.07)points and (3.43 ±0.81)points respec-tively,there was significant difference between the two groups(t =2.85,P =0.00),that in the treatment group was lower than the control group.The scores of hiccup symptoms on the 7 days after treatment in the treatment group and the control group were (1.27 ±0.66)points and (2.02 ±0.98)points respectively,there was significant difference between the two groups(t =1.07,P =0.00),that in the treatment group was lower than the control group.The total effective rates in the treatment group and the control group were 90%(54 /60)and 65%(39 /60)respectively,there was significant difference between the two groups(χ2 =10.75,P =0.00).The incidence rates of side effects in the treatment group and the control group were 1.7%(1 /60)and 6.7%(4 /60)respectively,there was no statistically significant difference between the two groups(χ2 =0.84,P =0.36).Conclusion Acupuncture combined with acu-point injection can significantly reduce the hiccup symptom score of post -stroke intractable hiccup patients on the 3, 5 and 7 days after treatment,and improve the total effective rate.

Objective To observe the clinical efficacy ofZhibai Dihuang Decoction combined with endocrine therapy for kidney-yin deficiency type of advanced prostate cancer and its influence on patient symptoms of hot flashes.Methods Totally 72 cases of advanced prostate cancer patients were randomly divided into the combined group (36 cases) and the control group (36 cases). Patients in the control group were treated with endocrine therapy, while patients in the combined group were additionally treated byZhibai Dihuang Decoction. After 12 weeks of treatment, serum prostate specific antigen (PSA), the international prostate symptom score (I-PSS), the clinical symptoms score, the number of cases of hot flashes and safety index before and after treatment were observed. Results In the course of treatment, the control group and the combined group each had 1 case lost to follow up. PSA and I-PSS in the two groups significantly decreased after treatment (P<0.01). The total efficiency rate of TCM syndrome was 94.3% (33/35) in the combined group, while it was 57.1% (20/35) in the control group, with significant difference (P<0.01). After treatment, the incidence of hot flushes was reduced after treatment in the combined group, but the control group increased, with significant difference (P<0.01). No adverse reaction was found in the two groups.ConclusionZhibai Dihuang Decoction combined with endocrine therapy is more effective than endocrine therapy alone, which can reduce the symptoms of hot flashes.

Hyperhomocysteinemia is an important independent risk factor for cardio-cerebrovas- cular diseases.Studies in recent years have suggested that hyperhomocysteinemia is also an independent risk factor for vascular dementia and Alzheimer's disease.Mild vascular cognitive impairment is the prophase of vascular dementia.Mainly through the damage of vascular wall structure and its function,homocysteine may has correlation with mild vascular cognitive impairment.

Adult ; Humans ; Male ; Maxillary Sinus ; Xanthogranuloma, Juvenile

Objective To investigate the effect of neutral amino acid on preventing Parkinson disease.Methods Mice were injected with L-Valine,L-Pheylalanine,D-Valine or L-Lysine before or after paraquat administration,by which prakinsonian mouse model was constructed.The paraquat immunoreactivity was observed within nigral cell bodies.Then neurodegeneration and ?-synuclein aggregation were observed by immunohistochemistry and Western blot.Results Paraquat immunoreactivity was abolished by the administration of L-Valine,L-Pheylalanine before paraquat exposure.Pre-treatment with these two amino acids also protected the paraquat-induced loss of nigrostriatal dopaminergic cells and formation of thioflavine S-positive aggregates.In contrast, paraquat-induced toxicity was unaffected if animals were injected with these two amino acids after paraquat exposure or pre-treated with D-Valine or L-Lysine.Conclusions L-type neutral amino acids such as L Valine and L-Pheylalanine can prevent paraquat-induced neurodegeneration and a synuclein pathology through a competitive inhibition mechanism with stereospecificity in the central nervous system (CNS).Neutral amino acid could protect the dopaminergic neuron in substantia nigra and may prevent Parkinson disease.

Adult ; Aged ; Airway Management ; Cyanides ; poisoning ; Female ; Humans ; Male ; Middle Aged ; Poisoning ; nursing ; Young Adult

Celecoxib ; Cell Proliferation ; drug effects ; Drug Resistance, Multiple ; Humans ; Interferon-alpha ; pharmacology ; K562 Cells ; Pyrazoles ; pharmacology ; Sulfonamides ; pharmacology

Objective To study the relationship between ultrasonography of arteria dorsalis pedis and Hemorheology in patient with diabetic foot.Methods According to with or without frank anabrosis,51 patients were devided into two sub-groups:anabrosis group (23 patients) and no-anabrosis group (28 patients).The correlativity was analysed between the parameters of ultrasonography in arteria dorsalis pedis and hemorheological indices on patients with diabetic foot.Results When compared to patients without ulcers,vascular inner diameter (D),peak systolic velocity (PSV),resistent index (RI) and pulsatility index (PI) on patients with frank anabrosis were decreased significantly,but whole blood viscosity at high shear rate (BVH),whole blood viscosity at low shear rate (BVL),plasma viscosity (PV),fibrinogen (Fib) were increased.Multiple regression analyses indicated that the relationship between BVH,BVL and D was presence,partial regression coefficient (r) was -0.004 and -0.009 ; the relationship between PSV and BVH,PV was intimate,r was -0.957 and -25.655 ; the relationship between RI and BVH,PI and BVH,PV,Fib were relatively intimate,r was -0.009 , -0.141 , -2.666 , -0.383 ,respectively.Conclusions The changes of hemorheology can aggravate the abnormality of hemodynamics and the degree of vascular lesion in small vessels of lower limb,so it is one of influencing factor leading to lower limb arterial ischaemia and diabetic foot deterioration.