1.Building and application of digital teaching data base of medical imaging
Zheng FANG ; Jiannong ZHAO ; Dajing GUO
Chinese Journal of Medical Education Research 2011;10(5):626-627
This article utilizes the latest digitization development trend of medical imaging teaching to illustrate the value of digitization in medical imaging, which discusses the setting up meaning, establishing methods, management and application, etc. of digital teaching data base.
3.Clinical characteristics of acute non-ST segment elevation myocardial infarction
Shumei ZHAO ; Luhua SHEN ; Fang NAN ; Chunyan GUO
Clinical Medicine of China 2008;24(6):554-556
Objective To study the clinical characteristics of acute non-ST segment elevation myocardial infarction(NSTEMI).Methods 211 patients of NSTEMI and STEMI underwent coronary artery angiography and echocardiogram.Patients'history and symptome were collected and the data of coronary artery angiography and echocardiogram were analyzed.Results Compared with STEMI,NSTEMI patients had more risk factors and postinfarction angina pectoris;severe coronary artery disease and three coronary vessel disease.But NSTEMI had relatively little effects on cardiac function.Conclusion NSTEMI always has more severe coronary artery disease and postinfarction ischemic effects.So more attention should be paid to its standard therapy.
4.The expression of GDNF and GFRα1 in childhood nephroblastoma and its clinical significance
Xue ZHANG ; Juan TIAN ; Yuechao ZHAO ; Fang GUO
Tianjin Medical Journal 2015;(6):628-630,705
Objective To investigate the expressions of GDNF and GFRα1 in childhood nephroblastoma, and therefore its clinical significance. Methods The expression levels of GDNF and GFRα1 were examined by immunohistochemistry of 30 parrafin samples from nephroblastoma section as well as 16 parrafin samples of peritumor renal tissue. Results The pos?itive expression rate of GDNF and GFRα1 in nephroblastoma were higher than those in normal renal tissue(66.7%vs 6.3%;63.3%vs 6.3%). GDNF and GFRα1 were strongly expressed in epithelium and embryo bud, but weakly expressed in lobus intermedius of nephroblastoma. There was no correlation between the expressions of GDNF and GFRα1 with histological types, clinical stage and metastasis of nephroblastoma of patients. Conclusion High expression of GDNF and GFRα1 in childhood nephroblastoma might indicate its role in tumor development.
5.Prognosis of hip fractures in elderly patients:Effects of albumin, lymphocyte and hemoglobin
Zhenheng WANG ; Yongchao FANG ; Xiangxiang KAN ; Ting GUO ; Jianning ZHAO
Chinese Journal of Tissue Engineering Research 2013;(52):9095-9100
BACKGROUND:Studies have shown that malnutrition was associated with death of elder people after fracture of hip, but there were no above-mentioned reports in China.
OBJECTIVE: To retrospectively analyze the relationship of blood albumin, total lymphocyte count and hemoglobin levels to prognosis when elder patients with fracture of hip were on admission.
METHODS:130 elderly patients with hip fractures aged ≥ 70 years were included underwent either total hip arthroplasty or bipolar arthroplasty. Admission serum albumin, total lymphocytecount and hemoglobin levels were recorded. The patients were fol owed up for 1 year or til the death. Survival data were available in 92 patients. Rates of survival were calculated by the Kaplan-Meier method and the Log-Rank test. Cox proportional hazard regression model received prognostic multivariate analysis.
RESULTS AND CONCLUSION:Of the 92 patients, albumin<35 g/L in 20 cases (22%), total lymphocyte count<1.5×106/L in 67 cases (73%), and hemoglobin<120 g/L in 56 cases (61%). Kaplan-Meier method showed that the survival rate of patients with normal albumin (≥ 35 g/L) was significantly higher than those with reduced albumin (<35 g/L) (P<0.01). No significant difference was detected in the survival rate of patients with normal total lymphocyte count (≥ 1.5×106/L) and reduced total lymphocyte count (<1.5×106/L) (P>0.05). The survival rate of patients with normal hemoglobin (≥ 120 g/L) was significantly higher than those with decreased hemoglobin (<120 g/L) (P <0.05). Cox multivariate analysis displayed that albumin decrease is an independent prognostic factor for death of patients with hip fracture. Results indicated that the prognosis of elder patients with hip fracture was strongly associated with their nutritional conditions. Albumin and hemoglobin levels at admission can be considered as important indexes for judging patient’s prognosis.
6.Study on risk factors of cardiovascular disease and the status of bone mineral density in women with hypoestrogenism
Fang ZHAO ; Xuetao GUO ; Yun CHENG ; Zifen YANG ; Huiping LIU
Chinese Journal of Obstetrics and Gynecology 2013;48(10):734-739
Objective To study risk factors of cardiovascular disease (CVD) and status of bone mineral density (BMD) in women with hypoestrogenism.Methods From Jul 2011 to April 2013,a total of 256 women with hypoestrogenism in the First Affiliated Hospital of Shanxi Medical University were enrolled in this retrospective study,which were divided into four groups:133 women in ppausal group,25 women in premature ovarian failure (POF) group,67 women in menopausal transition group and 31 women in premature ovarian failure transition group.General statue,CVD risk factors and BMD were compared among four groups.General statue include menopausal period,menopausal symptoms (Kupperman Index),CVD risk factors include body mass index,blood pressure,waist circumference,waist-hip ratio,blood lipids and glucose,BMD include left hip,lumbar spine bone mineral density and T or Z value.Results (1) The median menopausal period were 3.4 years in postmenopausal group and 3.6 years in premature ovarian failure group,which did not show no statistical difference (P > 0.05).Kupperman Index in four groups were 12 in postmenopausal group,9 in POF group,9 in menopausal transition group and 8 in premature ovarian failure transition group,which reached statistical difference (P < 0.05).(2) The difference of body mass index (BMI),waist circumference,waist-hip ratio,diastolic blood pressure were no statistically significant among four groups(P > 0.05) ; the systolic blood pressure in four groups were 120,110,110,110 mm Hg (1 mm Hg =0.133 kPa),their differences were statistically significance (P < 0.05); the high-density lipoprotein (HDL-C) was 1.6 mmol/L in postmenopausal group,and 1.3 mmol/L in premature ovarian failure transition group,their differences were all statistically significance (P < 0.05) ; the difference of the fasting plasma glucose (FPG) was not statistically different in 4 groups (P >0.05).(3) The abnormal rate of lower bone mass in lumbar spine were 57% (46/81) postmenopausal group,8/15 in POF group,32% (9/28) in menopausal transition group,12/19 in premature ovarian failure transition group,and osteoporosis was 9% (7/81),3/15,1% (3/28)and 0 respectively,their differences were statistically different (P < 0.05) ; the abnormal rate of BMD of left hip and lumbar spine of 11/15 and 12/16 in POF group was higher than 65% (53/81) in postmenopausal group.In the mean time,the abnormal rate of BMD of left hip and lumbar spine were,12/19 and 10/20 in premature ovarian failure transition group,which were significantly higher than 43% (12/28) and 39% (12/31) in the menopausal transition group.Conclusions The menopausal symptoms resulting from hypoestrogenism in natural postmenopausal women are mostly remarkable.The decrease of BMD in lumbar spine is more significant than that of left hip among postmenopausal women.Women with earlier menopause was prone to cause the changes of blood fat and abnormal of BMD,especially HDL-C decreased significantly compared with those natural postmenopause,it is more likely to cause CVD and osteoporosis.
7.Effects of Xinghuayu parenteral solution on hemodynamics and blood coagulation
Fang GUO ; Song ZHAO ; Hailong HUANG ; Yongli WAMG ; Haili ZHANG
Chinese Pharmacological Bulletin 1986;0(05):-
Aim To observe the effects of Xinghuayu parenteral(XHY) solution on hemodynamics, and try to understand its mechanism of pharmocological effects on hemodynamics. Methods Select normal and blood blot model rat to assay hemodynamic. Results ① Both 14 mg?kg -1 and 21 mg?kg -1 doses of XHY could decrease multiphasic hemodynamics index of rat blood blot model with different efficiency;these indexes included: plasm viscosity (P
8.Determination of Tetracyclic Triterpene Saponins in Sanqi Jiegu Pills and Stability of Saponins in Granula-tion
Jialin WANG ; Fang CHENG ; Jing ZHAO ; Runqin GUO
China Pharmacist 2014;(11):1873-1876
Objective:To establish an HPLC method for the determination gensenoside Rg1 , Rb1 and notogensenoside R1 in Sanqi Jiegu pills and to investigate the stability of saponins in the granulation process. Methods:The separation was performes on a COSMO-SIL 5 C18 MS-II(250 mm × 4. 6 mm,5μm)column with gradient elution using water and acetonitrile as the mobile phase, the flow rate was 1. 0 ml·min-1 , the detection wavelength was 203nm, the column temperature was 30℃, and the injection volume was 10 μl. The content change of triterpene saponins in Sanqi Jiegu pills prepared by the granulation process at different drying temperature was al-so investigated. Results:The linearity of notogenoside R1 , gensenoside Rg1 and gensenoside Rb1 was good within the range of 0. 211 8-2.648 0 μg·ml-1(r=0.999 7),0.566 1-7.076 0 μg·ml-1(r=0.999 7) and 0.317 2-3.964 5μg·ml-1(r=0.999 7) with the average recovery of 98. 2%(RSD=0. 82%,n=6), 98. 1%(RSD=0. 72%,n=6) and 98. 1%(RSD=0. 59%,n=6),respectively. The content of saponins in Saqi Jiegu pills was decreased obviously with the increase of the drying temperature. Conclusion:The meth-od is simple, quick and reliable, and can be applied in the quality control of Sanqi Jiegu pills. It is recommended that the drying tem-perature in the granulation process should be controlled below 60℃.
9.A preliminary study for special English teaching reform of medical laboratory
Wen LIU ; Dongsheng WANG ; Bin GUO ; Yan LEI ; Linxu ZHAO ; Fang LIN ; Yan XING ; Xiaolan GUO
Chinese Journal of Medical Education Research 2017;16(9):908-911
There are some problems with this course of medical laboratory special English, such as reference materials, teaching contents, teaching ways, the evaluation forms, etc. The department of medical laboratory of North Sichuan Medical College did exploratory reforms including 1+n teaching mode (one major teacher and several co-operational teachers in discussion section), Flipped classroom and interactive teaching, new formative assessment forms (usual performance combing final shows grade), etc. They used innovative teaching way with the purpose of establishing new teaching way , cultivating abilities of au-tonomous learning and comprehensive application.
10.HD7279's application to the analog electrocardiogram generator controlledby a SCM
Ying FANG ; Qing GUO ; Qing JIAO ; Yongxin GUO ; Chuanhua ZHAO ; Hao ZHENG
Chinese Medical Equipment Journal 1989;0(02):-
This paper introduces the application of H7279intelligent display chip to the selection and display of different kinds of analog electrocardiogram output by the analog electrocardiogram generator controlled by a single chip micyoco(SCM).