Objective To investigate the relationship between hOGG1 and XPD gene polymorphism and genetic susceptibility of gastric cancer.Methods This study was carried out in Dongying Shengli Petroleum Administration Bureau Hospital.Under the narrow band imaging(NBI) mode,the blood samples of a total of 98 gastric cancers and 80 controls without cancers were collected.Genetic polymorphisms of DNA repair genes were identified by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP),then its relationship with cancers was analyzed.Results Carrying 326Cys allele with the wine increased the risk of gastric cancer; Lys 751Gln genotype increased the susceptibility of the gastric cancers (OR =1.486,0.73 ～ 3.025).Conclusion Lys751 Gln genotype increases the risk of gastric cancer.

Objective To investigate the feasibility of application of plasma anticoagulant heparin and hepa-rin lithium instead of serum in clinical biochemistry.Methods The clinical data 50 healthy persons in our hospital were statistically analyzed.Results The Potassium (K),sodium (Na),calcium (Ca),low -density lipoprotein (LDL),lactate dehydrogenase(LDH),cytokines(CK),blood urea nitrogen(BUN),serum uric acid(UA),alkaline phosphatase(ALP),magnesium(Mg),the standard value of total cholesterol(CHO),serum total bilirubin(TBil), direct bilirubin(DBil),triglyceride(TG)and other items of anticoagulant heparin plasma were (4.42 ±0.27)mmol/L, (137.00 ±1.70)mmol/L,(2.56 ±0.41)mmol/L,(115.53 ±88.93)mmol/L,(5.06 ±1.18)mmol/L,(281.56 ± 67.36)mmol/L,(84.41 ±74.02)μmol/L,(0.99 ±0.18)U /L,(4.62 ±1.26)μg/L,(17.18 ±15.66)mmol/L, (2.22 ±2.66)μmol/L,(2.28 ±7.70)mmol/L,which were significantly lower than those in serum(t =-3.415,-2.017,-4.739,-3.571,-3.155,-2.778,-4.117,-7.65,-10.799,-5.677,-3.192,-8.625,-5.401,-3.483,all P <0.05.);The K,Na,TCa,BUN,UA,ALP,DBil,TP,Mg,CK,HDL -C,LDL,LDH and other items of lithium heparin anticoagulant plasma were (4.51 ±0.30)mmol/L,(137.06 ±1.56)mmol/L,(2.60 ±0.08)mmol/L, (5.08 ±1.22)mmol/L,(281.86 ±67.78)μmol/L,(84.83 ±74.82)U /L,(2.22 ±2.56)μmol/L,(74.15 ± 10.94)mmol/L,(0.99 ±0.17)μg/L,(118.47 ±92.77)U /L,(1.68 ±0.72)mmol/L,(2.55 ±0.66)mmol/L, (129.82 ±30.34)U /L,which were significantly lower than those in serum(t =-3.517,-3.273,-4.128,-3.101,4.749,-2.271,-4.586,-6.706,-10.095,-5.837,2.234,-7.309,-7.175,-14.875,all P <0.05.);The HDL -C,LDL,BUN,Cr,TBil,DBil,Na,Cl,UA,GGT,ALP,ALT,AST,TP,ALB,TBA,Mg,CHO,LDH, CK,CK -MB,AMS,TG,Glu 24 and other items of heparin lithium heparin anticoagulant plasma and serum had good correlation(r >0.800).Conclusion Plasma anticoagulant heparin and heparin lithium instead of serum is feasible in clinical biochemistry.

Adult ; Blood Cell Count ; Control Groups ; Female ; Humans ; Male ; Physicians ; Radiography, Interventional

Objective To observe the treatment effect of renal function and blood pressure in patient with blood pressure morning surge.Methods 34 patients take levoamlodipine 2.5 mg/q orally.35 patients take Fosinopril 10 mg/q orally.35 patients take Fosinopril lOmg/q and levoamlodipine 2.5 mg/q orally,continuing 12 months. Blood pressure,urinary albumin excretory rate,scrllm creatinine,urinary creatinine and calculated creatinine clearance at base line were measured.Results Blood pressure (P<0.01) and urinary albumin excretory rate (P<0.01) were decreased by compare to pretherapy in three groups.Post-treatment,urinary albumin excretory rate was reduced from 103.8±44.2 to (84.6±37.5)μg/min in the first group,from 102.9±45.4 to(82.7±38.4)μg/min in the second group,and from 109.8±40.5 to(51.2±40.1)μg/min in the last group.The difference for urinary albumin excretory rate was significant between prior treatment and post-treatment in every group (P<0.05).It is the same between the first group and the second.The difference for urinary albumin excretory rate was significant between the first group and the third group (P<0.01).The difference was significant between the second groud and the third group (P<0.01).Post-treatment,calculated creatinine clearance rate was increased from 84.6±7.4 to 88.2±7.1 in the first group,from 81.4±2.5 to 84.5±4.2 in the second group,and from 79.1±6.8 to 109.6±16.1 in the last group.The difference for calculated creatinine clearance rate was significant between prior treatment and post-treatment in the third group (P<0.01).Conclusion Blood pressure (P<0.01) and urinary albumin excretory rate were decreased by three methods.Three methods all protect renal function,and the third method is the best.

Radioactive 125I interstitial brachytherapy is easy to cause the intestinal tract tissue damage.Its mechanism possibly correlates to the quick renewal speed of the intestinal tract tissue and a majority of ceils in M, G2 and late S phases. The tolerant dose of intestinal tract tissue is approximately 160 Gy. If the absorbed dose is higher than the tolerant one, the intestinal tract tissue will be damaged. In the clinical practice of radio-active 125I interstitial brachytherapy, through the strict plan of the TPS system before the operation, by using ul-trasound, CT, MR/and other imaging technologies in the operating process and establishing the suitable barrier protection between the seeds and intestinal tract tissue, the radioactive damage of the intestinal tract tissue my be reduced.

Objective The PRESENT ( Physicians' Routine Evaluation of Safety and Efficacy of NovoMix 30 Therapy) study is a multinational clinical experience program to report the efficacy, safety and acceptability of NovoMix 30 (BlAsp 30) in patients with type 2 diabetes mellitus inadequately controlled with oral antidiabetic drugs (OADs). Methods A total of 4 754 type 2 diabetes patients inadequately controlled with oral antidiabetic drugs were enrolled in the study. All patients were prescribed BIAsp 30 in accordance with the approved labeling. Data were collected at baseline and at the end of 3 months treatment. Results The mean HbA1c, body mass index (BMI), age, and duration were (9.09±1.70)%, (24.30±2.68)kg/m2, (54.63±10.94)years, and (5.46 ±4.17) years separately. The mean daily dose was (0.43±0.14) U/kg at treatment initiation and (0.48±0.15) U/kg after 3 months treatment. After 3 months, the mean HbA1c, fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) were significantly reduced from baseline levels. The mean HbA1c decreased by (2.04± 1.57)%, FPG by a (3.51±2.55)retool/L, and PPG by a (6.51±4.02) mmol/L (all P<0.01). A significant proportion (49.4%) of the patients achieved target HbA1c of ≤7%. The overall rate of hypoglycaemic episodes (events/patient-yr) decreased from 10. 098 at baseline to 3. 810 at study end. The rate of major hypoglycaemia decreased from 0. 787 to 0.126, and the rate of nocturnal hypoglycaemia decreased from 2.356 to 0.547. Compared with previous treatment, more than 99% of the patients and physicians were "satisfied" or "very satisfied" with BIAsp 30 treatment. Conclusions BIAsp 30 was found to be safe and effective to improve the glycaemia control of type 2 diabetes inadequately controlled with OADs in routine clinical practice.

Objective To study the factors which affect the functional restoration of the elbow for adults with supracondylar or intercondylar fractures of the humerus treated with open reduction and internal fixation. Methods 22 patients with supracondylar or intercondylar fractures of the humerus were treated with open reduction and internal fixation from January, 1999 to December, 2004. They were followed up for an average of 30 months and complete clinical data were kept. The function of the elbow was evaluated with the Mayo elbow performance index. The relationship between the results and the factors —initial time of postoperative rehabilitation, fracture classification, operative approach and interval from injury to operation —were analyzed with cumulative logistic regression model of SAS software V8.2 (SAS institute, Cary, North Carolina). Results Of the 22 cases, 7 were excellent, 9 good, 5 fair and 1 poor. The excellent and good rates were 72.7%. And the odds ratio estimates of the 4 factors were 0.786, 0.299(B/A)0.221(C/A), 1.038, 0.197 respectively. Conclusions The initial time of postoperative rehabilitation, the fracture classification and the interval from injury to operation affect the functional restoration whereas the operative approach does not. Early operation, anatomical reduction, stable fixation and early rehabilitation will help improve the functional restoration.

Objective To analyze the CT features of large adrenal adenoma and to compare the pathological features of large adenoma and small adenoma in order to improve the diagnosis of large adenoma.Methods The unenhanced and enhanced CT images of 14 patients with large adrenal adenoma,proven surgically and pathologically and pathological features of small adrenal adenomas in 30 cases were retrospectively reviewed.The pathological features were evaluated in the cell composition,the incidence of cystic degeneration and hemorrhage of large adenoma and small adenoma.Results 14 large adenomas were unilateral and single,3 had distinct margin and 11 had indistinct margin,14 showed regular contour of round or ellipse,the size of tumors were 5 cm?5.5 cm～18 cm?20 cm.14 large adenomas presened heterogenous density in unenhanced CT study with CT value of-36～51 HU,and 3 showed calcification and 6 showed cystic degeneration.Most of the 14 adenomas presented heterogenenous enhancement after contrast administration.Pathologic examination indicated that the clear cells were predominant in the cell composition of small adenoma,while in the case of large adenoma,the proportion of compact cell predominance was equivalent to that of the clear cell and compact cell concomitance.3 small adenomas and 6 large adenomas had cystic degeneration,5 small adenomas and 4 large adenomas had hemorrhage respectively.Statistical analysis suggested that large adenoma had higher incidence of degeneration than that in small adenoma,while no difference was found in the cell composition and incidence of hemorrhage between large adenoma and small adenoma.Conclusion The large adrenal adenomas have higher incidence of degeneration than that in small adenoma,while no difference is found in cell composition and incidence of hemorrhage between large adenoma and small adenoma.

Objective To investigate the degree of cognitive impairment and its clinical significance of Binswanger's disease(BD),leukoaraiosis(LA) and LA with cerebral infarction(LA+CI).Methods Mini-mental state examination(MMSE) and clinical memory scale (CMS) were used to evaluate the cognitive impairment in 33 patients with BD, 27 patients with LA, 31 patients with LA+CI and 30 healthy controls.Results (1)The scores of MMSE and CMS in BD group, LA group, LA+CI group were significantly lower than those in healthy control group( P

Selective serotonin reuptake inhibitors (SSRIs),a new generation of anti-depressant agent,are mainly used to treat emotional disorders in clinical practice now.Recent studies have found that SSRIs can increase neurogenesis after cerebral ischemia,promote neurovascular reconstruction,and are conducive to the recovery of neurological function.Furthermore,SSRIs can improve the tolerance of ischemic tissue,exert anti-inflammation and anti-oxidation properties,reduce the blood-brain-barrier injury,and inhibit excitatory amino acid toxicity in order to exert neuroprotective effect.This article reviews the related research progress in SSRIs and ischemic stroke.