1.The prevention and treatment of the complications of endotracheal intubation in SICU
Chinese Journal of Primary Medicine and Pharmacy 2011;18(z1):7-8
Objective To discuss the clinical preventation and treatment of the complications induced by endotracheal intubation in SICU.Methods Retrospective analysis was used on 55 cases of intubated patients in our hospital nearly 2 years.Results The incidence of endotracheal intubation was 36.4%,pneumonia 23.6%,accidental extubation 5.5%,endotracheal ulcer 1.8%,tracheoesophageal fistula 1.8%,obstruction of tracheal catheter 1.8%,arytenoid dislocation 1.8%.Conclusion The causeof complications of endotracheal intubation in SICU were overtime intubation,tranma,excessive-pressure of the air cuff and local inflammation.Airway humidification,suitable sedation,accurate and moderate operation,extubation or tracheotomy,suitable cuff pressure and fiberoptic bronchoscopy examination could avoid such complications.
7.Silent information regulator 1 and cerebral ischemia
Xuan ZHANG ; Fuqiang GUO ; Ben WEI
International Journal of Cerebrovascular Diseases 2013;21(7):554-558
Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase,which plays an important role in cerebral ischemia.It mainly stabilizes cerebral vascular endothelium,prevents vascular stenosis and the anti-inflammatory and anti-oxidative stress effects after cerebral ischemia.This article reviews the protective effects of STRT1 and its related mechanisms in cerebral ischemia.
9.Relation of Toll-like Receptor 4 and Monocyte Chemoattractant Protein-1 with Acute Coronary Syndrome
Journal of Modern Laboratory Medicine 2016;31(5):84-87
Objective To investigate the relation of Toll-like receptor 4 (TLR4)and monocyte chemoattractant protein-1 (MCP-1)with acute coronary syndrome.Methods 60 patients with coronary heart disease patients including 39 cases of a-cute coronary syndrome (ACS group),21 cases of stable angina (SA group)from January 2015-March 2016 in Xi’an First Hospital were in this observation.ACS group was divided into acute myocardial infarction (AMI,n=21)and unstable angina pectoris (UAP,n=18).Another 30 cases with angiographically normal was included in control group.Enzyme-linked immu-nosorbent assay (ELISA)detection was used to detect the serum content of MCP-1,TLR4 expression was tested by flow cy-tometry.Triglyceride (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C)and high-density lipopro-tein cholesterol (HDL-C)were detected.Results TLR4 levels of ACS group was significantly higher than SA group (t=4.455,P=0.021).Serum MCP-1 levels of ACS group were significantly higher than SA group (t=3.220,P=0.002)and control group (t=6.197,P=0.000).MCP-1 levels of ACS group were higher than control group (t=2.306,P=0.025). The Spearman correlation test TLR4 was positively with MCP-1 (r=2.389,P=0.025).Conclusion MCP-1 and TLR4 may determine the severity of coronary heart disease,combined detection of MCP-1 and TRL4 can provide the clinical value for early diagnosis and treatment of ACS.
10.Highlighting Military Especially Naval Characters and Constructing the Process Management Mode of Graduate Education
Wenling MA ; Xuan ZHENG ; Junsheng GUO
Chinese Journal of Medical Education Research 2006;0(11):-
Graduate education is a major way for training advanced talents in the field of military preventive medicine,and the process management is the key step for training talents with high quality of theoretic creation and experimental skills.In order to cultivate excellent graduate students with distinct military especially naval characters,in recent years,we have made certain exploration and practices during the education management process,facilitating construction of educational and experimental platform,intensifying theoretic ability and lab skills,improving research project selection and design,emphasizing middle evaluation and so on.Now a new type of process management mode of graduate education in military preventive medicine with significant military character has come into being.