Adult ; Biomarkers, Tumor ; metabolism ; Calbindin 2 ; Female ; Follow-Up Studies ; Humans ; Mesothelioma ; metabolism ; pathology ; surgery ; Mucin-1 ; metabolism ; Peritoneal Neoplasms ; metabolism ; pathology ; surgery ; S100 Calcium Binding Protein G ; metabolism

Communicable Diseases ; Disease Outbreaks ; Humans ; Infection Control ; Science

Asthma ; diagnosis ; therapy ; Child ; Chronic Disease ; Cough ; diagnosis ; therapy ; Humans

Asthma ; diagnosis ; therapy ; Child ; Humans

laboratorian should understand and evaluate them correctly.

Child ; Child, Preschool ; Humans ; Hypersensitivity, Immediate ; prevention & control ; Infant ; Primary Prevention

Anti-Asthmatic Agents ; therapeutic use ; Asthma ; diagnosis ; drug therapy ; Emphysema ; Female ; Humans ; Male

Objective To study the inhibitory effect of Rompun anesthesia and operation on immune function of dogs.Methods We randomly divided 14 healthy dogs into Group A and Group B with 7 in each.Rompun anesthesia induced by intramuscular injection of 3.0 mg/kg Rompun was carried out in Group A while Rompun anesthesia and operation were applied in Group B.The venous blood samples were collected before and after anesthesia at 2,8,24,72,120 and 168 h for centrifugation to obtain sera.ELISA kit was used to evaluate the contents of serum IL-1β,IL-2,IL-4,IL-8 and TNF-α.Results Compared with those before anesthesia,the concentrations of IL-2,IL-1βand TNF-αin Group A significantly decreased at 2,8,24 and 72 h (P<0.05)and resumed the pre-anesthesia level from 120 to 168 h;however,the concentrations of IL-4 and IL-8 did not change significantly during 2 to 168 h (P>0 .05 ).Compared with those before anesthesia,the concentrations of IL-2 and IL-1βin Group B significantly decreased from 2 to 168h (P<0.05),while the concentrations of TNF-αand IL-8 significantly increased (P<0 .05 ).IL-2 and IL-1βcontents in Group B from 2 to 168 h were significantly decreased compared with those in Group A (P<0.05 ),whereas IL-8 and TNF-αincreased significantly (P<0.05 ). Conclusion Both Rompun anesthesia and operation stress can inhibit dogs'immune function,and the latter has a stronger inhibitory effect than the former.

Traditionally,arsenic is thought to be a strong toxicant,especially arsenic trioxide (As2O3 ).As2O3 leads to the damage of ocular surface,such as cornea,conjunctiva etc.,and the evidence of its damage to retinal function also has been found.However,arsenic is a double-edged sword,because it possesses well- remedial effect on some eye diseases,including proliferative diabetic retinopathy,lens posterior capsular opaciffcation,keratopathy,meIanoma and bleb scarring.At present,there is still few research literature was seen about the active mechanism of arsenic agents on eye damage or therapeutic effect.Some relative studies are still in an experimental stage.This offers us the new research direction in clinical treatment of eye diseases.It is believed that arsenic will play an incalculable role on experiment and clinical treatment of eye diseases as further development and research of technology.The relationship between arsenic and eye disease is summed by consulting internal and external literature.

MAPKKK (MEKK1 or ASK1)/MAPKK (SEK1 or MKK7)/JNK signal cascade is an important pathway which mediates apoptosis. MAPK phosphotase can deactivate JNK by dephosphorylation of JNK.The interaction between JNK and c-Jun can also be negatively regulated by NO through S-nitrosylation. SGK1 or Akt can result in deactivation of SEK1 through its phosphorylation at the Ser78 site.The c-FLIPL can block this cascade through binding with MKK7.GST Mu1-1 interferes and suppresses MEKK1-mediated apoptosis. GST Pi 1-1 and TRX have a dose-dependent inhibitory effect on ASK1 through forming protein complex. The deactivation of JNK can enhance drug resistance of tumor cells and counteract the injury from a wide variety of stimulus. Here,how these proteins induce deactivation of the pathway and mediate anti-apoptosis has been discussed.